Entry of Polypeptide Toxins into Animal Cells

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

1982 • 929 citations

Diphtheria Toxin

1977 • 780 citations

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

1978 • 744 citations

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.

1981 • 736 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Diphtheria toxin: mode of action and structure

1975 • 552 citations

Actions of cholera toxin and the prevention and treatment of cholera

1981 • 532 citations

Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model

1982 • 497 citations

Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides.

1979 • 482 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.

1980 • 451 citations

Mechanism of action of the toxic lectins abrin and ricin

1974 • 443 citations

Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins

1982 • 428 citations

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances.

1981 • 424 citations

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

1983 • 406 citations

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

1980 • 372 citations

Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.

1981 • 341 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

Golgi membranes contain an electrogenic H+ pump in parallel to a chloride conductance.

1983 • 310 citations

Toxic lectins and related proteins

1982 • 305 citations

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

1980 • 305 citations

Molecular Action of Toxins and Viruses

1982 • 298 citations

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule.

1981 • 291 citations

Diphtheria toxin forms transmembrane channels in planar lipid bilayers.

1981 • 281 citations

Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cells

1981 • 275 citations

Diphtheria toxin: mode of action and structure.

1975 • 242 citations

Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

1976 • 238 citations

Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles.

1982 • 234 citations

Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity.

1975 • 222 citations

Inhibition of protein degradation in isolated rat hepatocytes

1977 • 214 citations

The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit.

1981 • 201 citations

Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.

1982 • 200 citations

Association of diphtheria toxin with Vero cells. Demonstration of a receptor.

1978 • 195 citations

Internalization of lectins in neuronal GERL.

1977 • 192 citations

Immunotoxins: Hybrid Molecules Combining High Specificity and Potent Cytotoxicity

1982 • 181 citations

Suicide Transport: Destruction of Neurons by Retrograde Transport of Ricin, Abrin, and Modeccin

1982 • 178 citations

Receptor-mediated internalization of pseudomonas toxin by mouse fibroblasts

1980 • 176 citations

Subunit structure of Shigella cytotoxin.

1981 • 174 citations

Ammonia inhibition of protein degradation in isolated rat hepatocytes

1976 • 172 citations

Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe).

1982 • 161 citations

Subunit number and arrangement in Escherichia coli heat-labile enterotoxin

1981 • 156 citations

Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.

1983 • 153 citations

Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium.

1982 • 150 citations

Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa

1977 • 142 citations

Binding of triton X-100 to diphtheria toxin, crossreacting material 45, and their fragments.

1976 • 139 citations

Tetanus toxin fragment forms channels in lipid vesicles at low pH.

1982 • 138 citations

Archaebacterial elongation factor is ADP-ribosylated by diphtheria toxin

1980 • 125 citations

Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin.

1976 • 124 citations

Nucleotide Sequence and Expression of the Diphtheria tox 228 Gene in Escherichia coli

1983 • 120 citations

Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells

1979 • 120 citations

Mutant Chinese hamster ovary cells pleiotropically defective in receptor-mediated endocytosis.

1983 • 116 citations

On the Toxic Proteins Abrin and Ricin

1974 • 116 citations

Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma‐associated antigen p97

1982 • 116 citations

Interaction of diphtheria toxin with mammalian cell membranes.

1976 • 112 citations

Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.

1982 • 111 citations

Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine.

1980 • 109 citations

Chimeric toxins

1981 • 108 citations

Pathways involved in fluid phase and adsorptive endocytosis in neuroblastoma

1980 • 102 citations

Endocytosis of cholera toxin into neuronal GERL.

1978 • 101 citations

Ricin B chain is a product of gene duplication.

1981 • 100 citations

The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment a from diphtheria toxin

1977 • 99 citations

Endocytosis of cholera toxin in GERL-like structures of murine neuroblastoma cells pretreated with GM1 ganglioside. Cholera toxin internalization into Neuroblastoma GERL.

1979 • 99 citations

Photolabelling of cholera toxin subunits during membrane penetration

1981 • 99 citations

Diphtheria Toxin and Related Proteins: Effect of Route of Injection on Toxicity and the Determination of Cytotoxicity for Various Cultured Cells

1982 • 94 citations

Internalization of neuronal plasma membrane ricin receptors into the Golgi apparatus

1975 • 92 citations

Receptor-mediated internalization and degradation of diphtheria toxin by monkey kidney cells.

1979 • 90 citations

Receptor-mediated endocytosis of diphtheria toxin by cells in culture.

1982 • 88 citations

Lipid insertion of cholera toxin after binding to GM1-containing liposomes.

1981 • 87 citations

Monensin blocks the transport of diphtheria toxin to the cell cytoplasm.

1982 • 86 citations

Variants of hamster fibroblasts resistant to Ricinus communis toxin (ricin)

1976 • 85 citations

Importance of the Antigen-Binding Valency and the Nature of the Cross-Linking Bond in Ricin A-Chain Conjugates with Antibody

1982 • 84 citations

Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses

1983 • 84 citations

Binding, Uptake and Degradation of the Toxic Proteins Abrin and Ricin by Toxin‐Resistant Cell Variants

1978 • 82 citations

H+ ATPase of chromaffin granules. Kinetics, regulation, and stoichiometry.

1982 • 81 citations

The exotoxin of P. Aeruginosa: A proenzyme having an unusual mode of activation

1978 • 79 citations

Ultrastructural analysis of toxin binding and entry into mammalian cells

1974 • 77 citations

Primary structure of diphtheria toxin fragment B: structural similarities with lipid-binding domains.

1980 • 77 citations

Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells

1979 • 75 citations

Demonstration of diphtheria toxin receptors on surface membranes from both toxin-sensitive and toxin-resistant species.

1978 • 74 citations

Isolation and characterization of two mouse L cell lines resistant to the toxic lectin ricin

1976 • 72 citations

Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments.

1984 • 71 citations

Qualitative and quantitative interactions of lectins with untreated and neuraminidase-treated normal, wild-type, and temperature-sensitive polyoma-transformed fibroblasts

1975 • 71 citations

Thyrotropin-releasing hormone-diphtheria toxin-related polypeptide conjugates. Potential role of the hydrophobic domain in toxin entry.

1983 • 70 citations

ATP-dependent acidification of membrane vesicles isolated from purified rat liver lysosomes. Acidification activity requires phosphate.

1983 • 69 citations

Interaction of Shigella Shigae Cytotoxin with Receptors on Sensitive and Insensitive Cells

1980 • 67 citations

Bilayers containing gangliosides develop channels when exposed to cholera toxin

1978 • 67 citations

Insertion of diphtheria toxin into and across membranes: role of phosphoinositide asymmetry

1982 • 65 citations

Properties and action mechanism of the toxic lectin modeccin: Interaction with cell lines resistant to modeccin, abrin, and ricin

1978 • 65 citations

Methylamine stimulates the action of ricin toxin but inhibits that of diphtheria toxin.

1981 • 64 citations

Retrograde transport and effects of toxic ricin in the autonomic nervous system.

1980 • 64 citations

Mode of Inhibition of Diphtheria Toxin by Ammonium Chloride

1965 • 61 citations

Characterization and affinity labeling of the cationic phosphate-binding (nucleotide-binding) peptide located in the receptor-binding region of the B-fragment of diphtheria toxin.

1980 • 60 citations

Derivation of Lymphoma Variants With Reduced Sensitivity to Plant Lectins2

1974 • 56 citations

Diphtheria toxin: nucleotide binding and toxin heterogeneity.

1980 • 54 citations

Capping of cholera toxin-ganglioside GM1 complexes on mouse lymphocytes is accompanied by co-capping of alpha-actinin.

1983 • 54 citations

Internalization and degradation of cholera toxin by cultured cells: relationship to toxin action.

1982 • 53 citations

Amino-acid sequence of fragment A, an enzymically active fragment from diphtheria toxin.

1976 • 52 citations

Binding and uptake of diphtheria toxin by toxin-resistant Chinese hamster ovary and mouse cells.

1983 • 51 citations

Conformation-Dependent Antigenic Determinants in the Toxic Lectin Ricin

1975 • 50 citations

Binding of diphtheria toxin to phospholipids in liposomes

1980 • 50 citations

X-ray grade crystals of diphtheria toxin.

1982 • 50 citations

Effects of neuraminidase on lectin binding by wild-type and ricin-resistant strains of hamster fibroblasts

1977 • 49 citations

Localization in diphtheria toxin fragment B of a region that induces pore formation in planar lipid bilayers at low pH

1983 • 48 citations

Ligand interactions of diphtheria toxin. II. Relationships between the NAD site and the P site.

1980 • 47 citations

Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II.

1979 • 46 citations

Activation of choleragen by thiol: protein disulfide oxidoreductase.

1980 • 45 citations

Kinetics of adenosinediphosphoribosylation of elongation factor 2 in cells exposed to diphtheria toxin

1981 • 44 citations

Ligand interactions of diphtheria toxin. I. Binding and hydrolysis of NAD.

1980 • 42 citations

Analysis by lectin affinity chromatography of N-linked glycans of BHK cells and ricin-resistant mutants

1983 • 39 citations

Diphtheria toxin:receptor interaction. Characterization of the receptor interaction with the nucleotide-free toxin, the nucleotide-bound toxin, and the B-fragment of the toxin.

1981 • 39 citations

Lipid-protein interactions during ricin toxin insertion into membranes. Evidence for A and B chain penetration.

1983 • 38 citations

Killing of cultured hepatocytes by conjugates of asialofetuin and EGF linked to the A chains of ricin or diphtheria toxin

1982 • 38 citations

Studies of the mechanism of cell intoxication by diphtheria toxin fragment A-asialoorosomucoid hybrid toxins. Evidence for utilization of an alternative receptor-mediated transport pathway.

1982 • 37 citations

Activity of Diphtheria Toxin II. Early Events in the Intoxication of HeLa Cells

1969 • 37 citations

An endogenous dinucleotide bound to diphtheria toxin. Adenylyl-(3',5')-uridine 3'-monophosphate.

1981 • 37 citations

Cell surface receptors and their dynamics on toxin‐treated malignant cells

1976 • 33 citations

Entry of Shigella dysenteriae toxin into HeLa cells

1983 • 32 citations

Methylamine facilitates demonstration of specific uptake of diphtheria toxin by CHO cell and toxin-resistant CHO cell mutants

1982 • 31 citations

Reduction of ricin and other plant toxins by thiol:protein disulfide oxidoreductases

1982 • 31 citations

Preliminary crystallographic investigation of the protein toxin from corynebacterium diphtheriae.

1982 • 30 citations

Chinese hamster ovary cell mutants defective in the internalization of ricin.

1982 • 28 citations

Reversible and irreversible inhibitors of clustering of ?M in clathrin-coated pits on the surface of fibroblasts

1982 • 27 citations

Interaction of diphtheria toxin with phosphorylated molecules

1979 • 26 citations

Cell-Surface Changes in a Ricinus communis Toxin (Ricin)-Resistant Variant of a Murine Lymphoma2

1977 • 26 citations

A CNBR peptide located in the middle region of diphtheria toxin fragment B induces conductance change in lipid bilayers

1981 • 25 citations

Elongation‐Factor‐2‐Induced Sensitization of Ribosomes to Modeccin

1979 • 23 citations

Effects of lectins on the interaction of diphtheria toxin with mammalian cells

1979 • 23 citations

Preparation and properties of chimeric toxins prepared from the constituent polypeptides of diphtheria toxin and ricin. Evidence for entry of ricin A-chain via the diphtheria toxin pathway.

1982 • 22 citations

Modification of the cell surface with neuraminidase increases the sensitivities of cells to diphtheria toxin and Pseudomonas aeruginosa exotoxin

1979 • 22 citations

Suppression of Cytotoxicity of Diphtheria Toxin by Monoclonal Antibodies Against Phosphatidylinositol Phosphate

1982 • 22 citations

Effect of polymers of L-lysine on the cytotoxic action of diphtheria toxin

1982 • 21 citations

On the Mechanism of Toxin Resistance in Cell Variants Resistant to Abrin and Ricin

1978 • 21 citations

Enzyme treatment of KB cells: The altered effect of diphtheria toxin

1974 • 21 citations

Anion requirement and effect of anion transport inhibitors on the response of vero cells to diphtheria toxin and modeccin

1984 • 21 citations

Proteolytic cleavage of exotoxin a form Pseudomonas aeruginosa

1980 • 18 citations

Mechanism of resistance to ricin toxin in selected mouse lymphoma cell lines

1978 • 18 citations

Calmodulin antagonists sensitize cells to pseudomonas toxin

1984 • 18 citations

Gating of ion channels made by a diphtheria toxin fragment in phospholipid bilayer membranes.

1983 • 17 citations

Interactions between Abrus Lectins and Sephadex Particles Possessing Immobilized Desialylated Fetuin. Model Studies of the Interaction of Lectins with Cell Surface Receptors

1978 • 17 citations

Enhanced Internalization of Ricin in Nigericin-Pretreated Chinese Hamster Ovary Cells

1981 • 17 citations

Cholera toxin-stimulated cyclic AMP accumulation in glial tumor cells: modulation by Ca2+.

1981 • 17 citations

Essential role of calcium in cellular internalization of Pseudomonas toxin

1982 • 17 citations

Effect of ammonium chloride on receptor-mediated uptake of diphtheria toxin by Vero cells

1981 • 16 citations

Characterization of hybrid molecules containing fragment A from diphtheria toxin linked to concanavalin A or the binding subunit of ricin toxin.

1981 • 15 citations

Interaction of ricin‐sensitive and ricin‐resistant cell lines with other carbohydrate‐binding toxins

1982 • 14 citations

Protein synthesis : Translational and post-translational events

1984 • 13 citations

Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain

1982 • 10 citations

Enhanced internalization of ricin in nigericin-pretreated Chinese hamster ovary cells.

1981 • 9 citations

Receptor-mediated entry of protein toxins into cells.

1984 • 9 citations

Effects of pseudomonas toxin A, diphtheria toxin, and cholera toxin on electrical characteristics of turtle bladder.

1979 • 8 citations

Conformational Changes in Subunit A of Cholera Toxin Following the Binding of Ganglioside to Subunit B

1982 • 7 citations

Arming α2-macroglobulin with ricin A chain forms a cytotoxic conjugate that inhibits protein synthesis and kills human fibroblasts

1983 • 7 citations

Receptors for a cytotoxic lectin, abrin and their role in cell intoxication

1982 • 5 citations

A cytotoxic, photolabile cross-linking derivative of ricin

1982 • 2 citations