Arachidonic acid metabolism in skin: A review
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Abstract
References (238)
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Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.
1975 • 583 citations
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1979 • 206 citations
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1978 • 193 citations
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The mechanism of action of leukotrienes C4 and D4 in guinea-pig isolated perfused lung and parenchymal strips of guinea pig, rabbit and rat
1981 • 191 citations
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Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1.
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Leukotriene B4 induces human suppressor lymphocytes
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Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzymE
1979 • 168 citations
Effects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiency
1972 • 159 citations
Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.
1981 • 157 citations
Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism
1982 • 156 citations
The mode of action of aspirin-like drugs
1978 • 155 citations
Effects of indomethacin, 5,8,11,14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes
1980 • 153 citations
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1975 • 145 citations
Prevention of Glomerulonephritis and Prolonged Survival in New Zealand Black/New Zealand White F1 Hybrid Mice Fed an Essential Fatty Acid-deficient Diet
1981 • 145 citations
Increased prostaglandins E2 and F2alpha in human skin at 6 and 24 h after ultraviolet B irradiation (290− 320 nm).
1978 • 144 citations
Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation.
1980 • 144 citations
Arachidonic Acid Transformations in Normal and Psoriatic Skin
1979 • 144 citations
Specific binding of leukotriene B4 to a receptor on human polymorphonuclear leukocytes.
1983 • 142 citations
Conversions of prostaglandin endoperoxides by glutathione-S-transferases and serum albumins
1976 • 138 citations
The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs).
1980 • 138 citations
ISomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin
1976 • 137 citations
Properties of a novel preparation of prostaglandin synthetase from sheep seminal vesicles
1971 • 135 citations
Leukotriene A. Isolation from human polymorphonuclear leukocytes.
1980 • 133 citations
Prostaglandins and lymphokines in arthritis
1974 • 132 citations
Prostaglandin e1 treatment of NZB/NZW F1 hybrid MICE
1977 • 132 citations
Prostaglandins and chronic inflammation
1978 • 131 citations
THE INFLAMMATORY EFFECTS OF HYDROPEROXY AND HYDROXY ACID PRODUCTS OF ARACHIDONATE LIPOXYGENASE IN RABBIT SKIN
1981 • 128 citations
Species difference in increased vascular permeability by synthetic leukotriene C4 and D4
1981 • 123 citations
Biosynthesis of prostaglandin E2 in human skin: subcellular localization and inhibition by unsaturated fatty acids and anti-inflammatory drugs
1973 • 121 citations
Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4
1981 • 120 citations
Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.
1980 • 118 citations
Selective inhibition of platelet n — 8 lipoxygenase by 5,8,11-eicosatriynoic acid
1977 • 118 citations
Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis.
1969 • 116 citations
Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators.
1980 • 114 citations
Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid
1980 • 112 citations
Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. Comparison with ionophore A23187.
1980 • 109 citations
Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates
1980 • 109 citations
Leukotriene C4 stimulates TXA2 formation in isolated sensitized guinea pig lungs
1981 • 109 citations
New role for 15-hydroxyeicosatetraenoic acid. Activator of leukotriene biosynthesis in PT-18 mast/basophil cells.
1982 • 109 citations
A role for endogenous mono-hydroxy-eicosatetraenoic acids (HETEs) in the regulation of human neutrophil migration.
1980 • 106 citations
Resting macrophages produce distinct metabolites from exogenous arachidonic acid
1982 • 106 citations
Anti-inflammatory Agents as Inhibitors of Prostaglandin Synthesis in Man
1981 • 106 citations
Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells
1979 • 105 citations
Chemotactic response to some arachidonic acid lipoxygenase products in the rabbit eye
1981 • 103 citations
LEUKOTRIENES C4 AND D4 INDUCE PROSTAGLANDIN AND THROMBOXANE RELEASE FROM RAT PERITONEAL MACROPHAGES
1981 • 102 citations
The effects of indomethacin on arachidonic acid and prostaglandins e2 and f2alpha levels in human skin 24 h after u.v.B and u.v.C irradiation.
1978 • 100 citations
Role of phospholipase A2 in prostaglandin formation.
1978 • 98 citations
Benoxaprofen improves psoriasis. A double-blind study.
1983 • 96 citations
Lipoxygenase products modulate histamine release in human basophils
1981 • 95 citations
Cutaneous vascular reactions to prostaglandins in healthy subjects and in
1969 • 95 citations
Glucocorticoid in Inflammatory Proliferative Skin Disease Reduces Arachidonic and Hydroxyeicosatetraenoic Acids
1977 • 94 citations
Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages.
1982 • 93 citations
Esterification of an endogenously synthesized lipoxygenase product into granulocyte cellular lipids
1981 • 93 citations
12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, a chemotactic fatty acid, is incorporated into neutrophil phospholipids and triglyceride
1979 • 92 citations
Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential.
1979 • 92 citations
Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats
1974 • 90 citations
Prostaglandins and cyclic AMP in epidermis.
1975 • 90 citations
Tissue distribution of chloroquine, hydroxychloroquine, and desethylchloroquine in the rat
1967 • 90 citations
Dapsone in the treatment of lupus erythematosus
1981 • 89 citations
Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids
1982 • 89 citations
Biosynthesis and Metabolism of Prostaglandin E2in Human Skin
1972 • 87 citations
Extracellular phospholipase A2 mediates inflammatory hyperaemia
1981 • 82 citations
Increased cyclic GMP and decreased cyclic AMP levels in the hyperplastic, abnormally differentiated epidermis of psoriasis
1973 • 78 citations
THE EFFECTS OF INDOMETHACIN ON LONG-WAVE ULTRAVIOLET-INDUCED DELAYED ERYTHEMA
1977 • 72 citations
The level of phospholipase A2 activity is raised in the uninvolved epidermis of psoriasis
1983 • 72 citations
Anti-PGE antibodies inhibit in vivo development of cell-mediated immunity
1981 • 69 citations
Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds
1981 • 69 citations
HYDROCORTISONE‐INDUCED INHIBITOR OF PROSTAGLANDIN BIOSYNTHESIS IN RAT LEUCOCYTES
1980 • 68 citations
Changes in Arachidonic Acid Metabolism in UV-Irradiated Hairless Mouse Skin
1983 • 66 citations
The Thiol Groups of Fumarase
1967 • 65 citations
Benoxaprofen Improves Psoriasis
1983 • 63 citations
Leukotrienes: Mediators of Allergic Reactions and Inflammation
1981 • 63 citations
Mediator studies in skin blister fluid from patients with dual skin reactions after intradermal allergen injection
1982 • 62 citations
Prostaglandins and Cutaneous Inflammation
1975 • 62 citations
Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids
1972 • 59 citations
Effect of topical indomethacin on UVR-induced redness and prostaglandin E levels in sunburned guinea pig skin
1976 • 58 citations
Prostaglandin I2 as a potentiator of acute inflammation in rats
1978 • 57 citations
Pathophysiology of Psoriasis
1977 • 55 citations
Current history of cytoprotection
1981 • 54 citations
Absorption of Antimalarial Drugs in Human Skin
1958 • 54 citations
Immunosuppressive properties of leukotriene D4 and E4invitro
1982 • 53 citations
An inhibitor of lipoxygenase inhibits histamine release from human basophils
1980 • 53 citations
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway
1982 • 53 citations
Arachidonic acid metabolism in guinea pig skin
1982 • 53 citations
Inhibition by aspirin of bronchoconstriction due to leukotrienes C4 and D4 in the guinea pig
1981 • 52 citations
Phospholipase A activity in the skin. Modulators of arachidonic acid release from phosphatidylcholine
1979 • 51 citations
A novel preparation of human platelet lipoxygenase
1981 • 51 citations
Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung
1983 • 50 citations
Suppression of acute and chronic inflammation by orally administered prostaglandins
1981 • 50 citations
LIPOXYGENATION OF ARACHIDONIC ACID: A PIVOTAL STEP IN STIMULUS-SECRETION COUPLING IN THE PANCREATIC BETA CELL
1982 • 50 citations
Inhibition of B-16 melanoma growth by prostaglandin D2
1983 • 48 citations
Selective inhibitors of platelet lipoxygenase: 4,7,10,13-icosatetraynoic acid and 5,8,11,14-henicosatetraynoic acid
1981 • 48 citations
The nature of the prostaglandin-producing mononuclear cell in human peripheral blood.
1981 • 47 citations
Prostaglandin E2: Biosynthesis and effects on glucose and lipid metabolism in rat skin
1971 • 46 citations
PGI2: A potential mediator of inflammation
1978 • 46 citations
Hydroperoxyeicosatetraenoic acids potent inhibitors of lymphocyte responses
1983 • 46 citations
Increased Synthesis of Prostaglandins in the Guinea Pig Following Scalding Injury
1973 • 44 citations
Reduced Epidermal Cyclic Amp Accumulation Following Prostaglandin Stimulation: Its Possible Role In The Pathophysiology Of Psoriasis
1975 • 44 citations
Inhibitor(s) of prostaglandin synthesis in psoriatic plaque
1975 • 42 citations
Epidermal arachidonate lipoxygenase
1983 • 42 citations
Effects of prostaglandin D2 on rat serosal mast cells: discordance between immunologic mediator release and cyclic AMP levels.
1980 • 42 citations
Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone
1983 • 42 citations
SRS-A and leukotrienes
1982 • 40 citations
EFFECTS OF TOPICAL PROSTAGLANDIN E2 ANALOGUE ON NORMAL HAIRLESS MOUSE EPIDERMAL DNA SYNTHESIS
1977 • 39 citations
Epidermal Synthesis of Prostaglandins and their Effect on Levels of Cyclic Adenosine 3',5'-Monophosphate
1975 • 38 citations
Pathogenesis of Woronoff Ring in Psoriasis
1976 • 38 citations
Irradiation of human skin by short wavelength ultraviolet radiation (100–290 nm) (u.v.C): increased concentrations of arachidonic acid and prostaglandines E2 and F2alpha.
1978 • 37 citations
Recovery of prostaglandins in human primary irritant dermatitis
1974 • 36 citations
The Phospholipases A of Epidermis
1980 • 36 citations
The effects of photosensitizers and ultraviolet irradiation on the biosynthesis and metabolism of prostaglandins
1976 • 36 citations
Effect of Nonsteroid Anti-Inflammatory and Antipyretic Drugs on Prostaglandin Biosynthesis by Human Skin
1973 • 35 citations
Indomethacin inhibition of glutathione S-transferases
1983 • 34 citations
Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.
1980 • 32 citations
Radical scavenging and stimulation of prostaglandin synthesis not anti-inflammatory?
1982 • 32 citations
Alterations of prostaglandin E2-9-ketoreductase activity in proliferating skin
1977 • 31 citations
Prostaglandins and aspirin: An alternative view
1975 • 28 citations
Factors affecting prostaglandin synthesis by rat skin microsomes
1976 • 28 citations
Chapter 20. Arachidonate Lipoxygenase
1981 • 27 citations
CYTOLOGIC AND METABOLIC EFFECTS OF PROSTAGLANDINS ON RAT SKIN
1977 • 27 citations
Recovery of Prostaglandins in Human Primary Irritant Dermatitis
1974 • 27 citations
Prostaglandins E2, F2alpha and arachidonic acid levels in irradiated and unirradiated skin of psoriatic patients receiving PUVA treatment
1978 • 26 citations
Cyclic GMP Metabolism in Psoriasis: Activation of Soluble Epidermal Guanylate Cyclase by Arachidonic Acid and 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid
1980 • 26 citations
Leukotriene C<sub>4</sub> and Dimethylphenylpiperazinium-Induced Responses in Canine Airway Tracheal Muscle Contraction and Fluid Secretion
1983 • 25 citations
Detection of immunoreactive leukotrienes LTC4/D4 in skin-blister fluid after allergen testing in patients with late cutaneous reactions (LCR)
1985 • 24 citations
The role of prostaglandins in inflammatory reactions
1977 • 24 citations
Lipoxygenase products and the polymorphonuclear leucocyte
1980 • 23 citations
Effect of prostaglandins on cyclic nucleotide levels in cultured keratinocytes
1979 • 21 citations
Prostacyclin as a potent dilator of arterioles in the hamster cheek pouch [proceedings].
1978 • 21 citations
Arachidonic Acid Metabolism in Skin: Experimental Contact Dermatitis in Guinea Pigs
1982 • 21 citations
Control Mechanisms of Histamine Release from Human Basophils in vitro: The Role of Phospholipase A<sub>2</sub> and of Lipoxygenase Metabolites
1981 • 20 citations
The effects of histamine and prostaglandin D on rat mast-cell cyclic AMP and mediator release
1981 • 19 citations
New Model of a Scaling Dermatosis: Induction of Hyperproliferation in Hairless Mice with Eicosa-5,8,11-trienoic acid
1981 • 19 citations
The catabolism of prostaglandins by rat skin
1980 • 19 citations
Prostacyclin (PGI2) potentiates bradykinin-induced plasma exudation in rabbit skin [proceedings].
1978 • 18 citations
In Vitro Effects of Prostaglandin E2 on Cutaneous Vascular Smooth Muscle in the Dog And in Man
1973 • 18 citations
Phospholipase A Activity in the Epidermis
1972 • 17 citations
Treatment of NZB/W (“lupus”) mice with 15(S)-15 methyl PGE1
1980 • 14 citations
Stimulation of polymorphonuclear leucocyte phospholipase A2 activity by chloroquine and mepacrine
1982 • 14 citations
The aetiology of psoriasis: clues provided by benoxaprofen
2006 • 14 citations
In Vivo Chemotaxis Induced by Polyunsaturated Fatty Acids
1977 • 14 citations
Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis
1977 • 14 citations
Synthesis of prostaglandins by psoriatic skin
1977 • 13 citations
Prostaglandin production by human epidermal cells in vitro: A model for studying pharmacologic inhibition of prostaglandin synthesis
1974 • 13 citations
Thirty-Ninth Annual Meeting The Society for Investigative Dermatology, Inc
1978 • 12 citations
Vascular responses to prostanglandin E 1
1973 • 11 citations
Arachidonic acid metabolism in guinea pig skin: effects of chloroquine
1982 • 11 citations
Effect of Arachidonic Acid Metabolites on the Histamine Release from Human Basophils and Rat Mast Cells
1981 • 11 citations
What's New in Clinical Research
1978 • 11 citations
Effect of indomethacin on the cyclic AMP-dependent protein kinase
1980 • 11 citations
Inhibition of lymphocyte mitogenesis by an arachidonic acid hydroperoxide
1980 • 11 citations
Prostacyclin, thromboxane and prostaglandin F2αin suction blister fluid of human skin: Effect of systemic aspirin and local glucocorticosteroid treatment
1981 • 10 citations
DOES ULTRAVIOLET-EVOKED PROSTAGLANDIN FORMATION PROTECT SKIN FROM ACTINIC CANCER?
1978 • 10 citations
Inhibitor(s) of prostaglandin biosynthesis and epidermal injury
1977 • 10 citations
Benoxaprofen: effect on cutaneous lesions in psoriasis
1982 • 9 citations
Prostaglandin E2 in blister fluid of bullous diseases and experimental suction blisters
1977 • 9 citations
Prostaglandins in PUVA-treated psoriasis
1978 • 7 citations
Arachidonic acid metabolism in the murine eosinophil. III. Effect of nonsteroid anti-inflammatory drugs on lymphokine-directed eosinophil migration in vivo.
1983 • 7 citations
The relationship between development of ultraviolet erythema and release of prostaglandins in guinea pig skin
1981 • 6 citations
The effect of leukotrienes C4 and D4 on microcirculatory flow in humans
2006 • 6 citations
[Prostaglandin biosynthesis in psoriatic epidermis (author's transl)].
1980 • 5 citations
A human model system for the release of endogenous inhibitor(s) of prostaglandin biosynthesis
1977 • 5 citations
Increased suction blister concentrations of prostaglandin E and F2alpha in dermatitis herpetiformis
1979 • 4 citations
The effect of combined ultraviolet A irradiation and oral psoralens (PUVA) on skin arachidonic acid and prostaglandin concentrations in psoriasis [proceedings].
1978 • 3 citations
The biosynthesis of prostaglandins in psoriatic skin.
1979 • 3 citations
Biosynthèse des prostaglandines dans l'épiderme psoriasique.
1980 • 3 citations
Deleted Work
1955 • 0 citations