Neurotrophic Effects and Mechanism of Insulin, Insulin-Like Growth Factors, and Nerve Growth Factor in Spinal Cord and Peripheral Neurons

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Polyneuronal innervation of skeletal muscle in new‐born rats and its elimination during maturation.

1976 • 774 citations

Neurofilament gene expression: a major determinant of axonal caliber.

1987 • 705 citations

Neuromuscular transmission in new‐born rats

1970 • 701 citations

The retrograde axonal transport of nerve growth factor

1974 • 598 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.

1984 • 519 citations

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

1985 • 506 citations

Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton.

1984 • 496 citations

Characterization of the turning response of dorsal root neurites toward nerve growth factor.

1980 • 487 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

The nerve growth factor: its mode of action on sensory and sympathetic nerve cells.

1966 • 456 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo

1984 • 407 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Differential expression of neurofilament triplet proteins in brain development

1982 • 397 citations

Hormone families: pancreatic hormones and homologous growth factors

1980 • 375 citations

Observations on the elimination of polyneuronal innervation in developing mammalian skeletal muscle.

1978 • 363 citations

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

1986 • 335 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

THE FINE STRUCTURE OF MOTOR ENDPLATE MORPHOGENESIS

1969 • 305 citations

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1984 • 281 citations

Nucleotide sequence and evolution of a mammalian α-Tubulin messenger RNA

1981 • 275 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

The effect of prolonged, reversible block of nerve impulses on the elimination of polyneuronal innervation of new-born rat skeletal muscle fibers

1979 • 230 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers.

1985 • 228 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

Regulation of tubulin and actin mRNA production in rat brain: expression of a new beta-tubulin mRNA with development.

1983 • 205 citations

Identification of two human beta-tubulin isotypes.

1983 • 203 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

Modulations of neurofilament axonal transport during the development of rabbit retinal ganglion cells

1983 • 193 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

1987 • 190 citations

Denervation increases a neurite-promoting activity in extracts of skeletal muscle

1983 • 189 citations

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

1986 • 188 citations

Insulin-Mediated Regulation of Neuronal Maturation

1984 • 184 citations

Cloning and developmental expression of the murine neurofilament gene family

1986 • 180 citations

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

1988 • 179 citations

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

1985 • 174 citations

Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections.

1978 • 173 citations

Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

1988 • 172 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells.

1984 • 168 citations

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

1982 • 168 citations

Anomalous placement of introns in a member of the intermediate filament multigene family: an evolutionary conundrum.

1986 • 165 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells.

1988 • 160 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

Changes in the colchicine susceptibility of microtubules associated with neurite outgrowth: studies with nerve growth factor-responsive PC12 pheochromocytoma cells.

1982 • 153 citations

Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.

1988 • 153 citations

Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats

1986 • 144 citations

Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis.

1989 • 143 citations

Nerve growth factor regulates both the phosphorylation and steady-state levels of microtubule-associated protein 1.2 (MAP1.2).

1988 • 139 citations

Experiments on Motor Nerve Regeneration and the Direct Neurotization of Paralyzed Muscles by Their Own and by Foreign Nerves

1917 • 134 citations

Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions

1987 • 132 citations

Effects of phorbol ester tumor promoters and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells.

1982 • 118 citations

Differential Expression of Two Neural Cell-Specific β-Tubulin mRNAs During Rat Brain Development

1984 • 114 citations

Rapid axoplasmic transport of insulin-like growth factor I in the sciatic nerve of adult rats

1987 • 113 citations

Binding of [125]insulin to specific receptors and stimulation of nucleotide incorporation in cells cultured from rat brain

1980 • 111 citations

The level of nerve growth factor (NGF) as a function of innervation

1983 • 108 citations

Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells

1988 • 106 citations

A study of postnatal growth of skeletal muscle in the rat

1965 • 106 citations

Fine structure of initial outgrowth of processes induced in a pheochromocytoma cell line (PC12) by nerve growth factor

1979 • 92 citations

Insulin and somatemedin MSA promote nerve growth factor‐independent neurite formation by cultured chick dorsal root ganglionic sensory neurons

1982 • 89 citations

Fast and slow nerve growth factor binding sites in human neuroblastoma and rat pheochromocytoma cell lines: relationship of sites to each other and to neurite formation

1985 • 84 citations

Phorbol Ester Receptors: Autoradiographic Identification in the Developing Rat

1983 • 78 citations

Mitogenic response of human SH-SY5Y neuroblastoma cells to insulin-like growth factor I and II is dependent on the stage of differentiation.

1986 • 78 citations

Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells

1986 • 76 citations

Preferred Microtubules for Vesicle Transport in Lobster Axons

1987 • 71 citations

Studies on the regulation of beta-nerve growth factor gene expression in the rat iris: the level of mRNA-encoding nerve growth factor is increased in irises placed in explant cultures in vitro, but not in irises deprived of sensory or sympathetic innervation in vivo.

1986 • 70 citations

Insulin and related growth factors: effects on the nervous system and mechanism for neurite growth and regeneration

1988 • 70 citations

Restoration of focal multiple innervation in rat muscles by transmission block during a critical stage of development

1981 • 70 citations

Effect of tumor promoters on the response of cultured embryonic chick ganglia to nerve growth factor.

1978 • 70 citations

Differential expression of two neural cell-specific beta-tubulin mRNAs during rat brain development.

1984 • 58 citations

Cloning of a cDNA encoding the smallest neurofilament protein from the rat

1985 • 58 citations

The insulin-like growth factor-II (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography

1988 • 56 citations

Source of the stimulus for nerve terminal sprouting in partially denervated muscle

1982 • 55 citations

Effect of Nerve Growth Factor on the Expression of Colchicine-Binding Activity and 14-3-2 Protein in an Established Line of Human Neuroblastoma

1974 • 54 citations

A STUDY OF THE FACTORS INFLUENCING INNERVATION OF MUSCLES BY IMPLANTED NERVES

1951 • 53 citations

Regulation of mRNA levels for microtubule proteins during nerve regeneration

1983 • 51 citations

Insulin dependent neurite outgrowth in cultured embryonic mouse brain cells

1983 • 48 citations

Characterization of Insulin Stimulation of the Incorporation of Radioactive Precursors into Macromolecules in Cultured Rat Brain Cells*

1980 • 48 citations

Isolation of a cDNA for the rat heavy neurofilament polypeptide (NF‐H)

1986 • 47 citations

Tumor promoter receptors regulating neurite formation in cultured human neuroblastoma cells.

1983 • 45 citations

Neurite Formation Modulated by Nerve Growth Factor, Insulin, and Tumor Promoter Receptors

1985 • 43 citations

Variation with embryonic development and regional localization of specific [3H]phorbol 12,13-dibutyrate binding to brain.

1981 • 40 citations

Serum-free medium for cultures of the postnatal mouse cerebellum: Only insulin is essential

1983 • 36 citations

Nerve growth factor modulates tubulin transcript levels in pheochromocytoma PC12 cells

1987 • 36 citations

Subcellular Localization of Functionally Differentiated Microtubules in Squid Neurons: Regional Distribution of Microtubule‐Associated Proteins and β‐Tubulin Isotypes

1988 • 32 citations

Role of Insulin, Insulinlike Growth Factors, and Nerve Growth Factor in Neurite Formation

1987 • 26 citations

Organ and species specificity in chemical carcinogenesis

1983 • 24 citations

Molecular Mechanisms of Neurite Formation Stimulated by Insulin-like Factors and Nerve Growth Factor

1987 • 16 citations

The Conditions Necessary for the Sensation of Light

1883 • 1 citations