AT1 Receptor Interactions

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

International union of pharmacology. XXIII. The angiotensin II receptors.

2000 • 2,055 citations

Angiotensin II receptors and angiotensin II receptor antagonists.

1993 • 1,843 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

Angiotensin II receptor antagonists

2000 • 706 citations

Angiotensin II receptors

2019 • 703 citations

Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase

2001 • 450 citations

Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.

1990 • 324 citations

Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation

1992 • 317 citations

Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.

1996 • 310 citations

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT₁‐receptor subtype

1993 • 254 citations

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

1990 • 238 citations

Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension

1996 • 229 citations

Intracellular Trafficking of Angiotensin II and its AT₁and AT₂Receptors: Evidence for Selective Sorting of Receptor and Ligand

1997 • 227 citations

Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling

1996 • 213 citations

Converting Enzyme Determines Plasma Clearance of Angiotensin-(1–7)

1998 • 198 citations

Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277

1993 • 192 citations

Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist.

1993 • 182 citations

Contributions of the Brain Angiotensin IV–AT₄Receptor Subtype System to Spatial Learning

1999 • 176 citations

Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296

1992 • 169 citations

The Docking of Arg2 of Angiotensin II with Asp281 of AT1 Receptor Is Essential for Full Agonism

1995 • 156 citations

Mutation of Asn111 in the Third Transmembrane Domain of the AT1A Angiotensin II Receptor Induces Its Constitutive Activation

1997 • 155 citations

The Active State of the AT₁ Angiotensin Receptor Is Generated by Angiotensin II Induction

1996 • 150 citations

Angiotensin III: a central regulator of vasopressin release and blood pressure

2001 • 146 citations

Distinction between surmountable and insurmountable selective AT₁ receptor antagonists by use of CHO‐K1 cells expressing human angiotensin II AT₁ receptors

1999 • 144 citations

Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist

1993 • 143 citations

Partial agonists and G protein-coupled receptor desensitization

1999 • 139 citations

Angiotensin-(1–7): a bioactive fragment of the renin–angiotensin system

1998 • 128 citations

Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan

1994 • 127 citations

Nephron obstruction in nordihydroguaiaretic acid-induced renal cystic disease

1979 • 120 citations

Angiotensin-sensitive neurons in the rat paraventricular nucleus: relative potencies of angiotensin II and angiotensin III

1987 • 120 citations

Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)

1995 • 118 citations

Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.

1994 • 117 citations

Interaction of Phe8 of Angiotensin II with Lys199 and His256 of AT1 Receptor in Agonist Activation

1995 • 117 citations

Angiotensin (1???7) is an antagonist at the type 1 angiotensin II receptor

1994 • 108 citations

Agonist-induced Phosphorylation of the Angiotensin II (AT1A) Receptor Requires Generation of a Conformation That Is Distinct from the Inositol Phosphate-signaling State

2000 • 104 citations

The ligand binding site of the angiotensin AT1 receptor

1996 • 103 citations

Angiotensin II Receptor Antagonists: An Emerging New Class of Cardiovascular Therapeutics.

1999 • 103 citations

The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro

2001 • 101 citations

Role of Aromaticity of Agonist Switches of Angiotensin II in the Activation of the AT1 Receptor

1999 • 101 citations

Internalization of the rat AT_1a and AT_1b receptors: pharmacological and functional requirements

1994 • 95 citations

Processing of Angiotensin II (A-II) and (Sar¹Ala⁸)A-II by Cultured Bovine Adrenocortical Cells*

1986 • 95 citations

Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding

1999 • 88 citations

Binding of the antagonist []candesartan to angiotensin II AT1 receptor-tranfected Chinese hamster ovary cells

1999 • 86 citations

Angiotensin IV Is a Potent Agonist for Constitutive Active Human AT1 Receptors

2002 • 80 citations

Pharmacological properties of angiotensin II receptor antagonists.

1999 • 80 citations

Pharmacological profile of GR117289 in vitro: a novel, potent and specific non‐peptide angiotensin AT₁ receptor antagonist

1992 • 76 citations

Significance of angiotensin type 1 receptor blockade: why are angiotensin II receptor blockers different?

1999 • 69 citations

Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

1992 • 65 citations

Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model

1994 • 65 citations

A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists

2001 • 60 citations

Models and methods for studying insurmountable antagonism

2002 • 59 citations

Intracellular Trafficking of Angiotensin II and its AT1 and AT2 Receptors: Evidence for Selective Sorting of Receptor and Ligand

1997 • 56 citations

The serotonin‐S₂ Receptor: A receptor‐transducer coupling model to explain insurmountable antagonist effects

1986 • 52 citations

Interaction between the partially insurmountable antagonist valsartan and human recombinant angiotensin II type 1 receptors

2000 • 51 citations

Non-peptide Angiotensin II Receptor Antagonists.

1995 • 50 citations

Reversible and syntopic interaction between angiotensin receptor antagonists on Chinese hamster ovary cells expressing human angiotensin II type 1 receptors

2000 • 50 citations

Nonpeptide angiotensin II receptor antagonists: insurmountable angiotensin II antagonism of EXP3892 is reversed by the surmountable antagonist DuP 753.

1991 • 45 citations

Bioactive angiotensin peptides: focus on angiotensin IV

2001 • 44 citations

Pharmacological Properties of KT3–671, a Novel Nonpeptide Angiotensin II Receptor Antagonist

1995 • 42 citations

Lys 199 mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists

2000 • 40 citations

N- and C-terminal structure–activity study of angiotensin II on the angiotensin AT2 receptor

1998 • 36 citations

Receptor - Based Drug Design

1998 • 36 citations

Distinct binding properties of the AT1 receptor antagonist [3H]candesartan to intact cells and membrane preparations

2002 • 35 citations

In vitro pharmacological characterization of a new selective angiotensin AT1 receptor antagonist, UR-7280

1996 • 34 citations

Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptors

2003 • 30 citations

The cardiovascular effects of angiotensin-(1–7) in the rostral and caudal ventrolateral medulla of the rabbit

2000 • 30 citations

Kinetic studies on the interaction of nonlabeled antagonists with the angiotensin II receptor

1995 • 25 citations

Tight binding of the angiotensin AT1 receptor antagonist [3H]candesartan is independent of receptor internalization11Abbreviations: candesartan, 2-ethoxy-1-[(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1H-benzimidazoline-7-carboxylic acid; CHO-K1, Chinese hamster Ovary cells; CHO-hAT1 cells, CHO-K1 cells expressing human AT1 receptors; CHO-rAT1A-WT, CHO-K1 cells expressing wild type rat AT1A receptors; CHO-TL314-rAT1A, CHO-K1 cells expressing rat AT1A receptors with a truncated cytoplasmic tail …

2001 • 24 citations

Different types of angiotensin II receptor antagonism induced by BIBS 222 in the rat portal vein and rabbit aorta; the influence of receptor reserve.

1994 • 22 citations

Constitutive activity of G protein coupled receptors and drug action

2000 • 20 citations

Studies on inhibition of angiotensin II receptors in rabbit adrenal and aorta.

1989 • 20 citations

Binding characteristics of [3H]-irbesartan to human recombinant angiotensin type 1 receptors

2000 • 20 citations

In vitro and in vivo kinetic analysis of the interaction of a norbornyl derivative of propranolol with beta-adrenergic receptors of brain and C6 glioma cells; an irreversible or slowly reversible ligand.

1979 • 19 citations

Historical development of saralasin.

1979 • 17 citations

Distinctions between non-peptide angiotensin II AT1-receptor antagonists

2001 • 15 citations

Ligand efficacy and affinity in an interacting 7TM receptor model

1999 • 15 citations

Role of basic amino acids of the human angiotensin type 1 receptor in the binding of the non-peptide antagonist candesartan

2001 • 15 citations

Studies defining minimal receptor domains for angiotensin II.

1989 • 13 citations

Review: Structural requirements for signalling and regulation of AT1-receptors

2001 • 12 citations

Potential of the angiotensin II receptor 1 blocker eprosartan in the management of patients with hypertension or heart failure

2001 • 10 citations

In Vitro Pharmacological Properties of KRH-594, a Novel Angiotensin II Type 1 Receptor Antagonist.

1997 • 9 citations

Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors.

2000 • 6 citations

Structural requirements for signaling and regulation of AT1 angiotensin receptors

2001 • 3 citations