Role of basic amino acids of the human angiotensin type 1 receptor in the binding of the non-peptide antagonist candesartan

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.

1990 • 324 citations

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT₁‐receptor subtype

1993 • 254 citations

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

1990 • 238 citations

The renin-angiotensin system

1987 • 198 citations

Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist.

1993 • 182 citations

Distinction between surmountable and insurmountable selective AT₁ receptor antagonists by use of CHO‐K1 cells expressing human angiotensin II AT₁ receptors

1999 • 144 citations

Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist

1993 • 143 citations

Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)

1995 • 118 citations

Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.

1994 • 117 citations

Interaction of Phe8 of Angiotensin II with Lys199 and His256 of AT1 Receptor in Agonist Activation

1995 • 117 citations

Role of Aromaticity of Agonist Switches of Angiotensin II in the Activation of the AT1 Receptor

1999 • 101 citations

A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism

1997 • 94 citations

Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding

1999 • 88 citations

Binding of the antagonist []candesartan to angiotensin II AT1 receptor-tranfected Chinese hamster ovary cells

1999 • 86 citations

Pharmacological profile of GR117289 in vitro: a novel, potent and specific non‐peptide angiotensin AT₁ receptor antagonist

1992 • 76 citations

Functional studies but not receptor binding can distinguish surmountable from insurmountable AT1 antagonism.

1995 • 55 citations

Interaction between the partially insurmountable antagonist valsartan and human recombinant angiotensin II type 1 receptors

2000 • 51 citations

Non-peptide Angiotensin II Receptor Antagonists.

1995 • 50 citations

Reversible and syntopic interaction between angiotensin receptor antagonists on Chinese hamster ovary cells expressing human angiotensin II type 1 receptors

2000 • 50 citations

Lys 199 mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists

2000 • 40 citations

BMS‐180560, an insurmountable inhibitor of angiotensin II‐stimulated responses: comparison with losartan and EXP3174

1994 • 36 citations

In vitro pharmacological characterization of a new selective angiotensin AT1 receptor antagonist, UR-7280

1996 • 34 citations

Mutations in transmembrane segment VIJ of the AT₁ receptor differentiate between closely related insurmountable and competitive angiotensin antagonists

1994 • 24 citations

Pharmacology of LR-B/057, a Novel Orally Active AT1 Receptor Antagonist

1995 • 15 citations

In Vitro Pharmacological Properties of KRH-594, a Novel Angiotensin II Type 1 Receptor Antagonist.

1997 • 9 citations