Inhibition of Carcinogen Metabolism and Action by Disulfiram, Pyrazole, and Related Compounds

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Thomas, Springfield, Illinois

1965 • 2,935 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

1967 • 1,408 citations

Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten

1967 • 1,336 citations

METHODS IN CANCER RESEARCH

1969 • 1,197 citations

In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.

1976 • 457 citations

Treatment of Osteosarcoma

1964 • 370 citations

Biochemistry and Pharmacology of Ethanol

1979 • 353 citations

Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.

1973 • 328 citations

Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane

1977 • 328 citations

The Carcinogenic Aminoazo Dyes

1953 • 325 citations

Inhibition of Chemical Carcinogenesis

1978 • 321 citations

N-Hydroxylation: A New Metabolic Reaction Observed in the Rat with the Carcinogen 2-Acetylaminofluorene

1960 • 311 citations

Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds2

1977 • 309 citations

Inhibition of dopamine- β -hydroxylase by disulfiram

1964 • 305 citations

Inhibitors of Chemical Carcinogenesis

1978 • 304 citations

A DRUG SENSITISING THE ORGANISM TO ETHYL ALCOHOL

1948 • 279 citations

Selektive Erzeugung von Darmkrebs bei Ratten durch 1,2-Dimethyl-hydrazin

1967 • 273 citations

THE ROLE OF ACETALDEHYDE IN THE ACTIONS OF ETHANOL

1975 • 250 citations

Colon carcinogens: Their metabolism and mode of action

1971 • 234 citations

The disulfiram--ethanol reaction: a review.

1977 • 232 citations

Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.

1973 • 229 citations

Carcinoma of the Colon and Antecedent Epithelium.

1971 • 213 citations

Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen.

1973 • 212 citations

Metabolism of disulfiram and diethyldithiocarbamate in rats with demonstration of an in vivo ethanol-induced inhibition of the glucuronic acid conjugation of the thiol

1965 • 188 citations

Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.

1971 • 183 citations

Specific Carcinogenic and Teratogenic Effects of ‘Indirect’ Alkylating Methyl and Ethyl compounds, and their Dependency on Stages of Ontogenic Developments

1973 • 173 citations

Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds

1975 • 169 citations

[SELECTIVE INDUCTION OF BLADDER CANCER IN RATS BY DIBUTYL- AND N-BUTYL-N-BUTANOL(4)-NITROSAMINE].

1964 • 165 citations

Mechanism of Alkylation of Nucleic Acids by Nitrosodimethylamine

1968 • 162 citations

Studies on Methylazoxymethanol, the Aglycone of Cycasin: Methylation of Nucleic Acids in vitro

1966 • 148 citations

Activation by Chemical Carcinogens of γ-Glutamyl Transpeptidase in Rat and Mouse Liver 2

1973 • 142 citations

The Carcinogenic Action of 4-Aminodiphenyl and 3:2'-Dimethyl-4-Aminodiphenyl

1952 • 140 citations

Effects of pyrazole on hepatic function and structure.

1970 • 138 citations

CHEMICAL STRUCTURE AND CARCINOGENICITY OF ALIPHATIC HYDRAZO, AZO, AND AZOXY COMPOUNDS AND OF TRIAZENES, POTENTIAL IN VIVO ALKYLATING AGENTS*

1969 • 137 citations

Hepatic metabolism of N-hydroxy-N-methyl-4-aminoazobenzene and other N-hydroxy arylamines to reactive sulfuric acid esters.

1976 • 135 citations

Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes

1969 • 132 citations

Selektive Erzeugung von Blasenkrebs an Ratten durch Dibutyl- und N-Butyl-N-butanol(4)-nitrosamin

1964 • 130 citations

LIVER ALCOHOL DEHYDROGENASE-DPN-PYRAZOLE COMPLEX: A MODEL OF A TERNARY INTERMEDIATE IN THE ENZYME REACTION.

1963 • 118 citations

The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene.

1973 • 116 citations

The Formation of Acetaldehyde in the Organism after Ingestion of Antabuse (Tetraethylthiuramdisulphide) and Alcohol.

1948 • 116 citations

The Alkylation of Nucleic Acids of Rat and Mouse In Vivo by the Carcinogen 1,2-Dimethylhydrazine

1974 • 111 citations

Microsomal N-oxidation of the hepatocarcinogen N-methyl-4-aminoazobenzene and the reactivity of N-hydroxy-N-methyl-4-aminoazobenzene.

1976 • 103 citations

Brief Communication: Inhibition of Dimethylhydrazine-Induced Neoplasia of the Large Intestine by Disulfiram2

1975 • 103 citations

Formation of O6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine.

1977 • 103 citations

Tumor Induction in Germfree Rats With Methylazoxymethanol (MAM) and Synthetic MAM Acetate<xref ref-type="fn" rid="FN1">2</xref>

1967 • 103 citations

Fortschritte der Krebsforschung

1951 • 101 citations

1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pretreatment with disulfiram.

1979 • 88 citations

Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazine

1977 • 88 citations

Metabolic activation of procarbazine

1978 • 88 citations

Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Several Sulfur-Containing Compounds2

1974 • 86 citations

N-acetoxy-N-acetylaminoarenes and nitrosoarenes one-electron non-enzymatic and enzymatic oxidation products of various carcinogenic aromatic acethydroxamic acids

1972 • 86 citations

Toxicological implications op the mixed-function oxidase catalyzed metabolism of carbon disulfide

1975 • 86 citations

Assessment of the use of the Salmonella mutagenesis assay to determine the influence of antioxidants on carcinogen‐induced mutagenesis

1979 • 85 citations

Covalent Binding of Sulfur to Microsomes and Loss of Cytochrome P-450 during the Oxidative Desulfuration of Several Chemicals

1974 • 84 citations

Diethyldithiocarbamic acid methyl ester

1972 • 83 citations

The Dismutation of Formaldehyde by Liver Alcohol Dehydrogenase

1960 • 81 citations

Environmental health aspects of fungicides. I. Dithiocarbamates

1976 • 81 citations

Experimental Intestinal Cancer Research with Special Reference to Human Pathology

1979 • 80 citations

Carcinoma of the Colon and Antecedent Epithelium

1971 • 75 citations

Oxidative metabolism of carbon disulphide by the rat

1973 • 72 citations

Brief Communication: A Model System for Studies of Colon Carcinogenesis: Tumor Induction by a Single Injection of Methylazoxymethanol Acetate 2

1974 • 72 citations

Interaction between Tetraethylthiuram Disulfide and the Sulfhydryl Groups of d-Amino Acid Oxidase and of Hemoglobin

1966 • 71 citations

The occurrence of methylazoxymethanol in Cycas circinalis L.

1963 • 71 citations

Drug-induced destruction of cytochrome P-450.

1973 • 67 citations

1,1-Dimethylhydrazine (Unsymmetrical) Carcinogenesis in Mice. Light Microscopic and Ultrastructural Studies on Neoplastic Blood Vessels2

1973 • 66 citations

Endemic and Morphologic Similarities Existing between Spontaneous Colonic Neoplasms in Man and 3

1965 • 66 citations

S-DEMETHYLATION BY MICROSOMAL ENZYMES.

1964 • 65 citations

Disulfiram (Tetraethylthioperoxydicarbonic Diamide): A Reappraisal of Its Toxicity and Therapeutic Application

1979 • 64 citations

Mechanism of inhibition of aldehyde dehydrogenase by cyclopropanone hydrate and the mushroom toxin coprine

1979 • 62 citations

The Mechanisms of Action of the Carcinogenic Nitroso and Related Compounds

1973 • 62 citations

Disulfiram in the treatment of alcoholism; a review.

1979 • 62 citations

Interactions of disulfiram and diethyldithiocarbamate with serum proteins studied by means of a gel-filtration technique

1965 • 60 citations

Organ-specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases.

1977 • 60 citations

Interaction of ethanol and pyrazole with hepatic microsomes

1971 • 59 citations

Distribution and chemical forms of diethyldithiocarbamate and tetraethylthiuram disulphide (disulfiram) in mice in relation to radioprotection

1966 • 58 citations

In vivo and in vitro effects of thiuram disulfides and dithiocarbamates on hepatic microsomal drug metabolism in the rat*1

1979 • 57 citations

Impairment of hepatic microsomal drug metabolism in the rat during daily disulfiram administration

1976 • 57 citations

Formation of an S-glucuronide from tetraethylthiuram disulfide (Antabuse) in man

1963 • 56 citations

Evidence for metabolic alpha hydroxylation of N-nitrosopyrrolidine.

1978 • 56 citations

Comparative Carcinogenicity of <italic>N</italic>-Isopropyl-α-(2-Methylhydrazino)-<italic>p</italic>-Toluamide · HCI (Procarbazine Hydrochloride), Its Degradation Products, Other Hydrazines, and Isonicotinic Acid Hydrazide

1969 • 55 citations

Effects of pyrazole and 3-amino-1,2,4-triazole on methanol and ethanol metabolism by the rat

1973 • 55 citations

Detection and Estimation of Azomethane in Expired Air of l,2-Dimethylhydrazine-Treated Rats2

1976 • 54 citations

Carcinogene Wirkung von 1,2-Di�thylhydrazin an Ratten

1966 • 54 citations

Oxidative metabolism of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine) by rat liver microsomes.

1979 • 53 citations

Decomposition of Methylazoxymethanol, the Aglycone of Cycasin, in D2O

1972 • 53 citations

Methylhydrazine tumorigenesis in Syrian golden hamsters and the morphology of malignant histiocytomas.

1973 • 52 citations

Chemotherapy of Cancer

1974 • 51 citations

Inhibitors of colon carcinogenesis

1977 • 51 citations

Metabolic Fate ofN-n-Butyl-N-(4-hydroxybutyl)-nitrosamine and its Analogues: Selective Induction of Urinary Bladder Tumours in the Rat

1977 • 50 citations

Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats

1976 • 50 citations

VII. THE THERAPEUTIC EFFECTIVENESS OF ALKYL DITHIOCARBAMATES IN EXPERIMENTAL ANIMALS EXPOSED TO NICKEL CARBONYL

1958 • 50 citations

Inhibition of hexokinase by disulfiram and dlethyldithiocarbamate

1963 • 49 citations

A new drug for the treatment of alcoholism.

1956 • 49 citations

Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole.

1978 • 49 citations

Effects of dietary constituents on ultraviolet light-mediated carcinogenesis.

1978 • 48 citations

Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats.

1975 • 47 citations

Methane formation in vivo from N-isopropyl α(2-methylhydrazino)-ρ-toluamide hydrochloride, a tumor-inhibiting methylhydrazine derivative

1967 • 47 citations

Dimethylnitrosamine demethylation by reconstituted liver microsomal cytochrome P-450 enzyme system

1975 • 46 citations

Carbon disulfide. II. A proposed mechanism for the action of carbon disulfide on dopamine beta-hydroxylase.

1977 • 46 citations

DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis.

1978 • 46 citations

Dose Response to a Single Injection of Azoxymethane in Rats

1975 • 45 citations

Inhibition of Dimethylnitrosamine-Induced Strand Breaks in Liver DNA and Liver Cell Necrosis by Diethyldithiocarbamate 2

1977 • 45 citations

Inhibition of N-n-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats by administration of disulfiram in the diet.

1979 • 44 citations

Eight-year follow-up of viscose rayon workers exposed to carbon disulfide.

1976 • 44 citations

Role of Purified Cytochrome P-448 and Epoxide Hydrase in the Activation and Detoxification of Benzo[a]pyrene

1977 • 43 citations

Effects of Pyrazole and 3-Amino-1,2,4-triazole on the Metabolism and Toxicity of Dimethylnitrosamine in the Rat 2

1977 • 43 citations

Identification of the route of action of the carcinogen 3:2-dimethyl-4-aminobiphenyl in the induction of intestinal neoplasia.

1967 • 42 citations

Disulfiram Treatment of Alcoholism

1989 • 42 citations

Some biochemical aspects of N-nitroso compounds

1979 • 41 citations

Evidence for the hepatic metabolism of some monoalkylhydrazines

1969 • 41 citations

Formation of Acetaldehyde in the Organism in Relation to Dosage of Antabuse (Tetraethylthiuram‐disulphide) and to Alcohol‐concentration in Blood.

1949 • 41 citations

Lung Tumor Induction and Inhibition of Breast Adenocarcinomas by Hydrazine Sulfate in Mice<xref ref-type="fn" rid="FN2">2</xref>

1969 • 41 citations

A method for the determination of tetraethylthiuram disulphide (antabus, abstinyl) and diethyldithiocarbamate in blood and urine. some studies on the metabolism of tetraethylthiuram disulphide

1951 • 40 citations

Inhibition of Macromolecular Binding of Benzo[a]pyrene and Inhibition of Neoplasia by Disulfiram in the Mouse Forestomach2

1976 • 40 citations

Oral toxicity of ferric dimethyl‐dithiocarbamate (ferbam) and tetramethylthiuram disulfide (thiram) in rodents

1978 • 40 citations

A Sensitive Radioassay for Sulfhydryl Groups with Tetraethylthiuram Disulfide

1966 • 40 citations

Alkylated purines in the DNA of various rat tissues after administration of 1,2-dimethylhydrazine

1977 • 38 citations

Effect of dithiocarb on metabolism and covalent binding of carbon tetrachloride

1978 • 37 citations

CONJUGATES OF N-HYDROXY COMPOUNDS

1970 • 37 citations

DIETHYLDITHIOCARBAMATE THERAPY OF THALLOTOXICOSIS

1967 • 36 citations

Investigations into the hepatic metabolism of dimethylnitrosamine in the rat

1975 • 35 citations

The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver

1976 • 34 citations

Autoxydation N²‐substituierter Methylhydrazine; Beeinflussung der Cu‐ & Fe‐Katalyse durch Proteine, Desoxyribonucleinsäure (DNS) und EDTA

1965 • 32 citations

Studies on the metabolic fate of the14C-labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia

1966 • 31 citations

The Toxicity of Tetraethylthiuram Disulphide (Antabuse) to Mouse, Rat, Rabbit and Dog. ¹)

1952 • 30 citations

Modifications of drug metabolism by disulfiram and diethyldithiocarbamate II. d-glucuronic acid pathway

1976 • 30 citations

Biochemical Pharmacology of Disulfiram

1979 • 29 citations

Modifications of drug metabolism by disulfiram and diethyldithiocarbamate I. Mixed-function oxygenase

1976 • 29 citations

N-hydroxylation of t he carcinogen 2-acetylaminofluorence by rabbit-liver microsomes

1962 • 27 citations

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

1978 • 27 citations

The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse.

1979 • 26 citations

Evaluation of metabolic activation of 7,12-dimethylbenz(a)anthracene in vitro by aroclor 1254-induced rat liver S-9 fraction.

1980 • 24 citations

The relationship between chemical structure and protective effect of dithiocarbamate derivatives against experimental hepatic injury induced by carbon tetrachloride administration in rats

1966 • 24 citations

Separation of 1,2-dimethylhydrazine metabolites by high-pressure liquid chromatography

1976 • 23 citations

Metabolism of pyrazole. Structure elucidation of urinary metabolites.

1977 • 23 citations

Experimental colon cancer in the absence of intestinal contents in Sprague-Dawley rats.

1980 • 23 citations

Inhibition of azoxymethane-induced intestinal cancer by disulfiram

1978 • 22 citations

Reconstituted hamster liver microsomal enzyme system for N-hydroxylation of the carcinogen 2-acetylaminofluorene

1974 • 22 citations

Inhibitory Effect of Disulfiram on Rat Mammary Tumor Induction By N-2-Fluorenylacetamide and on its Metabolic Conversion To N-Hydroxy-N-2-fluorenylacetamide2

1980 • 21 citations

Carcinogenicity of N-nitrosamines related to N-butyl-N-(4-hydroxybutyl)nitrosamine and N,N,-dibutylnitrosamine in ACI/N rats.

1976 • 21 citations

Metabolism of the Colon Carcinogen Methylazoxymethanol Acetate

2015 • 20 citations

Inhibition of 1,2-Dimethylhydrazine-Induced Neoplasia of the Large Intestine in Female CF 1 Mice by Carbon Disulfide: Brief Communication 2

1978 • 20 citations

Metabolism in vivo of carbon disulfide to carbonyl sulfide and carbon dioxide in the rat

1978 • 19 citations

Effect of various treatments on toxicity of inhaled vinylidene chloride.

1977 • 18 citations

International Conference on Radioactive Isotopes In Pharmacology

1970 • 18 citations

The protective effects of diethyldithiocarbamate and cycloheximide on the multiple hepatic lesions induced by carbon tetrachloride in the rat

1978 • 18 citations

Pulmonary Tumours in Rats induced by Oral Hydrazine Sulphate

1966 • 17 citations

Detection of Mutagenicity of the Colon Carcinogen 1,2-Dimethylhydrazine by the Host-Mediated Assay and Its Correlation to Carcinogenicity

1978 • 17 citations

Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile

1978 • 16 citations

Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats

1977 • 15 citations

Methylation of intestinal and hepatic DNA in rats treated with methylazoxymethanol acetate

1977 • 14 citations

Effect of Colostomy on Intestinal Carcinogenesis by Methylazoxymethanol Acetate in Rats

1978 • 14 citations

Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay

1979 • 14 citations

Pyrazole-Induced Thyroid Necrosis: A Distinct Organ Lesion

1978 • 13 citations

The effects of disulfiram on rat liver mitochondrial monoamine oxidase

1978 • 12 citations

γ-Glutamyltransferase and the Inhibition of Azo Dye-Produced Neoplasia by Concomitant Administration of Disulfiram23

1980 • 12 citations

Studies on methylazoxymethanol synthesis of ¹⁴C and ³H labelled methylazoxymethyl‐acetate

1968 • 11 citations

Biochemical Pharmacology of Pyrazoles

1979 • 11 citations

Effects of pyrazole on rat liver tryptophan oxygenase

1976 • 11 citations

Carcinogenicity of Procarbazine

1974 • 10 citations

Studies of the metabolism of N-nitrosopyrrolidine in the rat

1979 • 10 citations

Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.

1978 • 10 citations

Synthesis of the glucuronic acid conjugate of methylazoxymethanol.

1979 • 10 citations

The formation of azoxymethane, a colon carcinogen, during the chemical oxidation of methylamine

1980 • 9 citations

Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat

1970 • 9 citations

Carcinogenic azo dyes. XI. Analysis of biliary and urinary metabolites of 3'-methyl-4-(methylamino)azobenzene in rat.

1979 • 8 citations

The influence of physostigmine on the activation of methylazoxymethanol acetate, a potent carcinogen, by a serum factor in vitro

1972 • 8 citations

Methylation with (Z)-methyl-ONN-azoxymethanol: the nature of the reactive species

1972 • 8 citations

Activation of glutathionase in rat liver during carcinogenesis

1969 • 6 citations

Specifity and sensitivity of the inhibition of drug metabolism following inhalation of carbon disulphide-air mixtures.

1976 • 6 citations

Mechanism of methylation of DNA bases by symmetrical dimethylhydrazine

1978 • 5 citations

Carcinogenic azo dyes. XII. Detection of new metabolites of aminoazo dyes by rat liver.

1979 • 3 citations

[Absorption, metabolism, and effect of carbon disulfide on the organism. VI. Attempted chromatographic manifestation of reaction of carbon disulfide in the blood with amino acids].

1953 • 3 citations

Deleted Work

1955 • 0 citations