Oxidative metabolism of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine) by rat liver microsomes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

1973 • 500 citations

Microsomal oxidase IV: Properties of a mixed-function amine oxidase isolated from pig liver microsomes

1972 • 257 citations

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

1976 • 228 citations

[109] Methods for the elevation of hepatic microsomal mixed function oxidase levels and cytochrome P-450

1967 • 168 citations

The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions

1977 • 130 citations

Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine

2006 • 90 citations

Metabolic activation of procarbazine

1978 • 88 citations

Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazine

1977 • 88 citations

A Modified Spectrophotometric Method for the Determination of Hydrazine

1962 • 69 citations

Carcinogenic and other adverse effects of procarbazine in nonhuman primates.

1978 • 64 citations

Dehydroxylation and deacetylation of N-hydroxy-N-2-fluorenylacetamide by rat liver and brain homogenates

1965 • 55 citations

Oxidative demethylation of N-methylhydrazines by rat liver microsomes

1969 • 48 citations

Über den Metabolismus eines cytostatisch wirksamen Methylhydrazin-Derivates (Natulan)

1965 • 48 citations

Methane formation in vivo from N-isopropyl α(2-methylhydrazino)-ρ-toluamide hydrochloride, a tumor-inhibiting methylhydrazine derivative

1967 • 47 citations

The N-oxidation of alkylhydrazines catalyzed by the microsomal mixed-function amine oxidase

1973 • 47 citations

BIOCHEMICAL ASPECTS OF THE ACTIONS OF DRUGS ON SPERMATOGENESIS

1967 • 41 citations

Fetal malformations produced in rats by N‐isopropyl‐α‐(2‐methylhydrazino)‐p‐toluamide hydrochloride (procarbazine)

1969 • 41 citations

Evidence for the hepatic metabolism of some monoalkylhydrazines

1969 • 41 citations

Further evidence on the nature of microsomal metabolism of procarbazine11Procarbazine, a registered trade name by Hoffman-LaRoche, Nutley, New Jersey. and related alkylhydrazines

1970 • 40 citations

Oxidation of p-(N1-methylhydrazino methyl) -N-isopropyl benzamide (procarbazine)∗∗Natulan (Roche). to the methylazo derivative and oxidative cleavage of the N2-C bond in the isolated perfused rat liver

1969 • 39 citations

Induction of Tumors in Rats With Procarbazine Hydrochloride

1968 • 36 citations

Monoamine Oxidase Inhibition by a New Carcinostatic Agent, N-Isopropyl- -(2-Methylhydrazino)-p-Toluamide (MIH)

1965 • 33 citations

Microsomal N-Hydroxylation of p-Chloroacetanilide

1975 • 32 citations

CARCINOGENIC ACTIVITY OF A NEW ANTITUMOR AGENT, N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-P-TOLUAMIDE, HYDROCHLORIDE (NSC-77213).

1964 • 27 citations

SOME PHARMACOLOGIC PROPERTIES OF A NEW ANTITUMOR AGENT, N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-P-TOLUAMIDE, HYDROCHLORIDE (NSC-77213).

1964 • 26 citations

Inhibition of 1,2-Dimethylhydrazine Metabolism by Disulfiram

1977 • 24 citations

THE TUMOR-INHIBITORY EFFECTS OF THE METHYLHYDRAZINE DERIVATIVE RO 4-6467/1 (NSC-77213).

1963 • 23 citations

Methylazo and methylazoxy compounds; new types of antitumour agents

1964 • 22 citations

N-demethylation of p-(N1-methylhydrazino methyl)-N-isopropyl benzamide (procarbazine),∗∗Natulan (Roche). a cytostatically active methylhydrazine derivative, in the intact rat and in the isolated perfused rat liver

1969 • 21 citations

THE MICROSOMAL METABOLISM OF CARCINOGENIC AND/OR THERAPEUTIC HYDRAZINES

1977 • 11 citations

Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.

1978 • 10 citations

Synthese der Terephthal‐ und Isophthal‐aldehydsäure‐ester

1938 • 9 citations

The activity of ibenzmethyzin hydrochloride against the human transplantable tumors human epithelioma No. 3 and human adenoma No. 1

1966 • 5 citations