CONJUGATES OF N-HYDROXY COMPOUNDS

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Enzymatic O-Methylation of Epinephrine and Other Catechols

1958 • 1,291 citations

DETOXICATION MECHANISMS

1960 • 760 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

The Metabolic Activation of Carcinogenic Aromatic Amines and Amides1

2015 • 349 citations

8-(N-2-Fluorenylacetamido) guanosine, an Arylamidation Reaction Product of Guanosine and the Carcinogen N-Acetoxy-N-2-fluorenylacetamide in Neutral Solution^*

1967 • 335 citations

Mechanisms of Oxygen Metabolism

1957 • 312 citations

N-Hydroxylation: A New Metabolic Reaction Observed in the Rat with the Carcinogen 2-Acetylaminofluorene

1960 • 311 citations

The Synthesis of Aryl-D-glucopyranosiduronic Acids¹

1955 • 311 citations

The biochemistry of foreign compounds

1968 • 263 citations

The enzymatic reduction of chloramphenicol, p-nitrobenzoic acid and other aromatic nitro compounds in mammals.

1957 • 229 citations

The N- and ringhydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat.

1960 • 207 citations

THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.

1964 • 202 citations

The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.

1966 • 196 citations

Chemical Carcinogenesis.

1963 • 180 citations

Enzyme-Catalyzed Reactions of the Carcinogen N -Hydroxy-2-fluorenylacetamide with Nucleic Acid

1968 • 179 citations

Separation of Steroid Sulfokinases

1958 • 164 citations

The enzymatic reduction of the N-hydroxy derivatives of 2-acetylaminofluorene and related carcinogens by tissue preparations.

1965 • 156 citations

CARCINOGENESIS: A BROAD CRITIQUE

1968 • 152 citations

Nucleic Acid Guanine: Reaction with the Carcinogen N -Acetoxy-2-Acetylaminofluorene

1966 • 151 citations

Molecular Geometry and Carcinogenic Activity of Aromatic Compounds. New Perspectives

1969 • 137 citations

The metabolism of 4-nitroquinoline-1-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas.

1966 • 130 citations

Reaction of esters of aromatic -hydroxy amines and amides with methionine : A model for binding of amine carcinogens to protein

1966 • 125 citations

Enzymatic deacetylation of N-hydroxy-2-acetylaminofluorene by liver microsomes.

1966 • 122 citations

Enzymatic N-Hydroxylation of the Carcinogen 2-Acetylaminofluorene and the Metabolism of N-Hydroxy-2-acetylaminofluorene-9-14C in Vitro

1964 • 120 citations

Mutations and decreases in density of transforming DNA produced by derivatives of the carcinogens 2-acetyl-aminofluorene and N-methyl-4-aminoazobenzene.

1968 • 118 citations

Possible Role of P-450 in the Oxidation of Drugs in Liver Microsomes*

1966 • 117 citations

Mycobactin. A growth factor for Mycobacterium johnei. Part II. Degradation, and identification of fragments

1954 • 115 citations

THE METABOLISM OF URETHANE AND RELATED COMPOUNDS

1965 • 114 citations

Sulfotransferase Activation of N-Hydroxy-2-acetylaminofluorene in Rodent Livers Susceptible and Resistant to this Carcinogen

1968 • 114 citations

The N-Hydroxylation of 4-Acetylaminobiphenyl by the Rat and Dog and the Strong Carcinogenicity of N-Hydroxy-4-acetylaminobiphenyl in the Rat

1961 • 110 citations

The biochemistry of aromatic amines. 10. Enzymic N-hydroxylation of arylamines and conversion of arylhydroxylamines into o-aminophenols

1964 • 104 citations

Hadacidin, a New Growth-Inhibitory Substance in Human Tumor Systems

1962 • 103 citations

The Correlation of Experimental Carcinogenesis and Cancer in Man

2015 • 99 citations

N-Benzoyloxy-N-methyl-4-aminoazobenzene: its carcinogenic activity in the rat and its reactions with proteins and nucleic acids and their constituents in vitro.

1967 • 98 citations

Pulcherrimin, The Pigment of Candida Pulcherrima

1953 • 95 citations

Mechanism of p-nitrobenzoate reduction in liver: the possible role oc cytochrome P-450 in liver microsomes.

1968 • 94 citations

Biochemistry of carcinogenesis.

1968 • 93 citations

Structure of the Ferrichrome Compounds^1,2

1961 • 88 citations

Species Variations in the N - and Ring-Hydroxylation of 2-Acetylaminofluorene and Effects of 3-Methylcholanthrene Pretreatment.

1967 • 87 citations

ASPERGILLIC ACID: AN ANTIBIOTIC SUBSTANCE PRODUCED BY ASPERGILLUS FLAVUS

1947 • 83 citations

The structure of the glucuronide of sulphadimethoxine formed in man

1965 • 75 citations

The biochemistry of aromatic amines. The metabolism of 2-naphthylamine and 2-naphthylhydroxylamine derivatives

1966 • 74 citations

The sulfotransferases of guinea pig liver.

1966 • 74 citations

CARCINOGENESIS AND INHIBITION OF THE WALKER 256 TUMOR IN THE RAT BY TRANS-4-ACETYLAMINOSTILBENE, ITS N-HYDROXY METABOLITE, AND RELATED COMPOUNDS.

1964 • 73 citations

Der Ort der N-Oxydation des Anilins im h�heren Tier

1961 • 71 citations

Methyl and Phenyl Glycosides of the Common Sugars

1957 • 67 citations

The physicochemical mechanisms of carcinogenesis

1968 • 66 citations

Carcinogenic and chronic toxic hazards of aromatic amines

1963 • 65 citations

The carcinogenic and mutagenic properties of N-hydroxy-aminonaphthalenes.

1968 • 64 citations

Reactions in vitro of some tissue nucleophiles with the glucuronide of the carcinogen N-hydroxy-2-acetylaminofluorene.

1968 • 64 citations

Glucuronic acid, free and combined : chemistry, biochemistry, pharmacology, and medicine

1966 • 62 citations

The Conversion of the Carcinogen N-Hydroxy-2-fluorenylacetamide to o-Amidophenols by Rat Liver in Vitro

1969 • 60 citations

ACTIVATION AND DETOXIFICATION OF N-2-FLUORENYLACETAMIDE IN MAN.

1964 • 55 citations

Dehydroxylation and deacetylation of N-hydroxy-N-2-fluorenylacetamide by rat liver and brain homogenates

1965 • 55 citations

Reaction of drugs with microsomal liver hydroxylase: Its influence on drug action

1968 • 55 citations

Aspartase-Catalyzed Synthesis of N-Hydroxyaspartic Acid^*

1963 • 54 citations

The enzymic synthesis of aryl sulphamates

1960 • 53 citations

N-Hydroxylation of 2-Acetylaminofluorene in the Rabbit

1962 • 50 citations

Hydroxylamino- und Nitrosobiphenyl: Biologische Oxydationsprodukte von 4-Aminobiphenyl und Zwischenprodukte der Reduktion von 4-Nitrobiphenyl

1967 • 49 citations

Urinary excretion of N-hydroxy derivatives of some aromatic amines by rabbits, guinea pigs, and dogs

1966 • 49 citations

Some aspects of the metabolism of urethane and N-hydroxyurethane in rodents

1968 • 46 citations

Stimulierung einiger mikrosomaler Fremdstoff-Oxydationen durch Phenobarbital, Methylcholanthren und Chlorphenothan, einzeln und in Kombinationen

1967 • 46 citations

Differences in the Metabolism of N-Hydroxy-N-2-fluorenylacetamide in Male and Female Rats^*

1964 • 46 citations

The biochemistry of aromatic amines. 9. Mercapturic acids as metabolites of aniline and 2-naphthylamine

1963 • 46 citations

Biliary excretion of the O-glucuronide of N-hydroxy-2-acetylamino-fluorene by the rat and rabbit.

1967 • 45 citations

The Biochemistry of Bladder Cancer

1963 • 42 citations

Phenol-O-methyltransferase

1968 • 41 citations

N-hydroxy metabolites of 2-acetylaminophenanthrene and 7-fluoro-2-acetylaminofluorene as proximate carcinogens in the rat.

1966 • 41 citations

Studien Zum Ablauf Der Substitution XII. Umlagerung Und Thermischer Zerfall Acylierter Hydroxylamine

1957 • 41 citations

Reactivity of the diacetyl derivative of the carcinogen 4-hydroxyaminoquinoline-1-oxide with DNA, RNA, and other nucleophiles

1968 • 41 citations

The Liver and Bile Metabolism.

1969 • 41 citations

Acetyl transfer in arylamine metabolism

1966 • 41 citations

722. Studies in relation to biosynthesis. Part VIII. The structure of mycelianamide

1956 • 40 citations

Reaction of the glucuronide of the carcinogen N-hydroxy-2-acetylaminofluorene with nucleic acids

1969 • 40 citations

The effect of carbon monoxide on the hydroxylation of aniline and N-ethylaniline by microsomal enzymes

1965 • 40 citations

N‐substituierte Arylhydroxylamine und deren Umwandlungsprodukte

1944 • 39 citations

Verschiedene Induktion der mikrosomalen N- und p-Hydroxylierung von Anilin und N-�thylanilin bei Kaninchen

1967 • 38 citations

114. The reaction of phenylhydroxylamine and 2-naphthylhydroxylamine with thiols

1962 • 37 citations

A mechanism of orthol-hydroxylation of aromatic amines in vivo

1960 • 36 citations

Studies on the N-hydroxylation and carcinogenicity of 4-aminoazobenzene and related compounds.

1966 • 35 citations

The metabolism of N-hydroxyurethane in relation to its carcinogenic action: Conversion into urethane and an N-hydroxyurethane glucuronide

1966 • 35 citations

Rearrangement of O-arenesulfonyl phenylhydroxylamines

1968 • 34 citations

ULTRASTRUCTURAL CHANGES IN THE RAT LIVER PRODUCED BY N-2-FLUORENYLDIACETAMIDE.

1964 • 33 citations

Einige Eigenschaften der Anilin-hydroxylierenden Enzyme in Mikrosomen

1963 • 32 citations

Arylhydroxylamines. Part IV. Their colorimetric determination

1964 • 30 citations

N-Hydroxylation in Aminostilbene Carcinogenesis

1965 • 30 citations

Possible role of the glucuronide conjugate in the biochemical mechanism op binding of the carcinogen N-hydroxy-2-acetylaminofluorene to rat-liver deoxyribonucleic acid in vivo

1969 • 29 citations

Nitrosobenzol und Phenylhydroxylamin als Zwischenstoffe der biologischen Reduktion von Nitrobenzol

1963 • 29 citations

The biochemistry of aromatic amines. 8. Synthesis and detection of di-(2-amino-1-naphthyl) hydrogen phosphate, a metabolite of 2-naphthylamine in dogs

1961 • 27 citations

N-hydroxylation of arylamines by bladder mucosa

1966 • 27 citations

THE EFFECTS OF ADRENALECTOMY, HYPOPHYSECTOMY, AND CASTRATION ON THE URINARY METABOLITES OF 2-ACETYLAMINOFLUORENE IN THE RAT.

1964 • 27 citations

N-hydroxylation of t he carcinogen 2-acetylaminofluorence by rabbit-liver microsomes

1962 • 27 citations

Aromatic Amines III. Note on Bis(2-amino-1-naphthyl) Phosphate, a Urinary Metabolite of 2-naphthylamine

1959 • 25 citations

On the Structure of the Glucuronide of N-Hydroxy-2-acetylaminofluorene

1965 • 25 citations

N-Hydroxylierung von 2-Aminofluoren durch Lebermikrosomen

1961 • 25 citations

Studies on Nitro-Reducing Enzymes of Swine Liver

1961 • 24 citations

THE ACETYLATION OF 2-AMINOFLUORENE AND THE DEACETYLATION AND CONCURRENT REACETYLATION OF 2-ACETYLAMINOFLUORENE BY RAT LIVER SLICES

1955 • 24 citations

Effects of pituitary hormones and prefeeding N-hydroxy-N-2-fluorenylacetamide on the metabolism of this carcinogen and on physiologic parameters.

1966 • 24 citations

Biosynthesis and Studies of the Alkaline Sensitivity of the NO-Glucuronide of the Carcinogen N-2-Fluorenylacethydroxamic Acid^*

1967 • 24 citations

Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.

1963 • 23 citations

Species differences in the hydroxylation of aniline and N-ethylaniline by liver microsomes

1965 • 22 citations

Alteration of the metabolism of the carcinogen N-2-fluorenylacetamide by acetanilide

1968 • 22 citations

Enzymic O-Methylation of Iodinated Phenols and Thyroid Hormones

1964 • 20 citations

Meth�moglobinbildung durch Sulfonamide im System Leberhomogenat, Erythrocyten, NADPH und Sauerstoff

1965 • 19 citations

Elimination of N-hydroxy arylamines from the blood of guinea pigs

1968 • 19 citations

1001. Arylhydroxylamines. Part II. Phenylhydroxylamine-N- and -O-sulphonic acids

1962 • 19 citations

The metabolism of N-2-fluorenylhydroxyl-amine in male and female rats

1966 • 17 citations

Interaction between liver microsomes and compounds capable of undergoing enzymic hydroxylation

1967 • 16 citations

The oxidation of N-2-Fluorenamine and 4-Aminobiphenyl by peracetic acid

1964 • 15 citations

Effects of adrenocorticotropic hormone and growth hormone on the metabolism of N-hydroxy-N-2-fluorenylacetamide and on physiologic parameters.

1967 • 15 citations

Bis(2-amino-1-naphthyl) phosphate, a Metabolite of Betana Phthylamine in Human Urine

1963 • 15 citations

THE EFFECTS OF HEPATOTOXIC AGENTS AND OF LIVER GROWTH ON THE URINARY EXCRETION OF THE N-HYDROXY METABOLITE OF 2-ACETYLAMINOFLUORENE BY RATS.

1964 • 14 citations

N-hydroxylation of the carcinogen 2-acetylaminofluorene by human liver tissue

1967 • 11 citations

Biosynthetic preparation of the NO-glucosiduronic acid of N-acetyl-N-phenylhydroxylamine

1967 • 11 citations

Isolation of N-hydroxy-p-aminopropiophenone from the urine of rabbits injected with p-aminopropiophenone

1967 • 9 citations

Metabolism of continuously fed 14C-labeled N-hydroxy-N-2-fluorenylacetamide at various intervals: effect of pituitary hormones.

1967 • 9 citations

A Comparison of Impaired Function with Morphologic Changes Occurring in Livers of Rats Ingesting <italic>N</italic>-2-Fluorenyldiacetamide

1958 • 9 citations

Metabolism of the glucuronide of N-hydroxy-2-acetylaminofluorene in the rat.

1969 • 8 citations

Enzymatic N-O-methylation of hydroxamic acids

1968 • 8 citations

Behaviour of the NO-β-<scp>d</scp>-glucosiduronic acid of N-acetyl-N-phenylhydroxylamine as a substrate for β-glucuronidase

1968 • 7 citations

Metabolism of 2-acetamidofluorene in the steppe lemming

1965 • 6 citations

Pituitary hormones and the metabolism of N‐hydroxy‐N‐2‐fluorenylacetamide in female rats

1967 • 4 citations

Synthesis of 2-nitrosofluorene by peracetic acid oxidation of 2-aminofluorene

1968 • 4 citations

The carinogenicity of N-hydroxy-N-2-fluorenyl-acetamide and the matabolism of N-2-fluorenyl-acetamide in Praomis (mastomys) natalensis

1968 • 3 citations