1 Pattern Formation in Zebrafish–Fruitful Liaisons between Embryology and Genetics

Stages of embryonic development of the zebrafish

1995 • 11,263 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio

1996 • 1,633 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

A genetic screen for mutations affecting embryogenesis in zebrafish.

1996 • 1,317 citations

Production of clones of homozygous diploid zebra fish (Brachydanio rerio)

1981 • 1,232 citations

Embryonic Development and Induction

1939 • 1,175 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

1995 • 1,060 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

The zebrafish midblastula transition

1993 • 711 citations

Origin and organization of the zebrafish fate map

1990 • 692 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

1997 • 627 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Cell movements during epiboly and gastrulation in zebrafish

1990 • 552 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis

1995 • 521 citations

The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos

1988 • 521 citations

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

1997 • 518 citations

β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

1996 • 516 citations

Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation

1993 • 502 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

The formation of the mesoderm in urodelean amphibians

1969 • 472 citations

Identification and cloning of localized maternal RNAs from xenopus eggs

1985 • 464 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

A homeobox gene essential for zebrafish notochord development

1995 • 462 citations

Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish

1993 • 458 citations

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1994 • 449 citations

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin

1995 • 436 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

1996 • 408 citations

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

1997 • 404 citations

Analysis of Dishevelled signalling pathways during Xenopus development

1996 • 402 citations

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

1995 • 390 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm

1993 • 365 citations

Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog

1997 • 356 citations

Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

1997 • 354 citations

The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail

1997 • 354 citations

Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise

1997 • 348 citations

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.

1996 • 345 citations

Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4

1995 • 344 citations

Cell motility driving mediolateral intercalation in explants of Xenopus laevis

1992 • 342 citations

dino and mercedes, two genes regulating dorsal development in the zebrafish embryo

1996 • 325 citations

Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish

1996 • 323 citations

Activation and organization of the central nervous system in amphibians. Part I. Induction and activation

1952 • 319 citations

�ber die Induktionsf�higkeit der verschiedenen Bezirke der Neurula von Urodelen

1933 • 301 citations

Order and coherence in the fate map of the zebrafish nervous system

1995 • 292 citations

Caudalization of neural fate by tissue recombination and bFGF

1995 • 290 citations

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio

1996 • 289 citations

Mutations affecting development of the midline and general body shape during zebrafish embryogenesis

1996 • 287 citations

A mutation that changes cell movement and cell fate in the zebrafish embryo

1989 • 257 citations

Lithium-induced respecification of pattern in Xenopus laevis embryos

1986 • 253 citations

A transient array of parallel microtubules in frog eggs: Potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axis

1988 • 249 citations

Microtubule arrays of the zebrafish yolk cell: organization and function during epiboly

1994 • 234 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

The function and mechanism of convergent extension during gastrulation of Xenopus laevis

1985 • 231 citations

goosecoid Expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas

1994 • 227 citations

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage

1996 • 224 citations

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

1994 • 213 citations

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

1996 • 213 citations

Conservation of BMP signaling in zebrafish mesoderm patterning

1997 • 210 citations

Differential Regulation ofchordinExpression Domains in Mutant Zebrafish

1997 • 210 citations

bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus

1995 • 203 citations

Cell lineage of zebrafish blastomeres

1985 • 198 citations

Mutations affecting development of the notochord in zebrafish

1996 • 194 citations

Maternal β-catenin establishes a ‘dorsal signal’ in early Xenopus embryos

1996 • 191 citations

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

1995 • 185 citations

Dynamic microtubules and specification of the zebrafish embryonic axis

1997 • 181 citations

The vertebrate organizer: structure and molecules

1996 • 173 citations

The zebrafish epiboly mutants

1996 • 169 citations

A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish

1997 • 168 citations

Cell rearrangement during gastrulation ofXenopus:direct observation of cultured explants

1991 • 163 citations

nodal induces ectopic goosecoid and lim 1 expression and axis duplication in zebrafish

1995 • 163 citations

Microtubule-mediated transport of organelles and localization of β-catenin to the future dorsal side of Xenopus eggs

1997 • 159 citations

Basic FGF as an inducer of anteroposterior neural pattern

1995 • 145 citations

Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos

1996 • 143 citations

β-Catenin Has Wnt-like Activity and Mimics the Nieuwkoop Signaling Center inXenopusDorsal–Ventral Patterning

1995 • 142 citations

Specification of the Zebrafish Nervous System by Nonaxial Signals

1997 • 137 citations

Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of β-catenin

1995 • 136 citations

floating head and masterblind Regulate Neuronal Patterning in the Roof of the Forebrain

1997 • 136 citations

Activation ofSiamoisby theWntPathway

1996 • 133 citations

Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish

1994 • 132 citations

Fish are like flies are like frogs: Conservation of dorsal‐ventral patterning mechanisms

1997 • 123 citations

Fine structure of the chorion and site of sperm entry in the egg of Brachydanio

1983 • 123 citations

Mesoderm induction in zebrafish

1996 • 118 citations

Pattern formation in the vertebrate neural plate

1994 • 114 citations

Distribution of tissue progenitors within the shield region of the zebrafish gastrula

1995 • 112 citations

Transplantation experiments on developing teleosts (Fundulus and Perca)

1936 • 108 citations

Gastrulation : movements, patterns, and molecules

1991 • 97 citations

one‐eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube

1997 • 95 citations

An activated form of type I serine/threonine kinase receptor TARAM-A reveals a specific signalling pathway involved in fish head organiser formation

1996 • 89 citations

On the convergent cell movements of gastrulation in Fundulus

1992 • 81 citations

Loss of cerebum function ventralizes the zebrafish embryo

1997 • 81 citations

The development of isolated blastoderms of Fundulus heteroclitus

1936 • 78 citations

Contribution of Early Cells to the Fate Map of the Zebrafish Gastrula

1994 • 78 citations

Organizing the Xenopus Organizer

1991 • 75 citations

Establishment of the axis in chordates: facts and speculations

1997 • 66 citations

Transparent things: Cell fates and cell movements during early embryogenesis of zebrafish

1995 • 65 citations

Induction and patterning of the vertebrate nervous system

1995 • 64 citations

The Two-gradient Hypothesis in Primary Induction. The Combined Effect of Two Types of Inductors Mixed in Different Ratios

1961 • 61 citations

The DVR-1 (Vg1)Transcript of Zebrafish Is Maternally Supplied and Distributed throughout the Embryo

1993 • 60 citations

Implications for dorsoventral axis determination from the zebrafish mutation janus

1994 • 59 citations

The role of the yolk syncytial layer in determination of the plane of bilateral symmetry in the rainbow trout, Salmo gairdneri Richardson

1983 • 58 citations

Induction of Axial Mesoderm by zDVR-1, the Zebrafish Orthologue ofXenopusVg1

1996 • 57 citations

Spatial regulation offloating head expression in the developing notochord

1997 • 53 citations

Structures Developed in Amphibians by Implantation of Living Fish Organizer

1936 • 52 citations

Synergistic Effects of Vg1 and Wnt Signals in the Specification of Dorsal Mesoderm and Endoderm

1996 • 51 citations

The sperm entry site during fertilization of the zebrafish egg: Localization of actin

1992 • 49 citations

Bone morphogenetic protein-4 expression characterizes inductive boundaries in organs of developing zebrafish

1997 • 48 citations

Ingression during Early Gastrulation of Fundulus

1996 • 40 citations

Localized axis determinant in the early cleavage embryo of the goldfish, Carassius auratus

1997 • 40 citations

The orientation of the dorsal/ventral axis of zebrafish is influenced by gravitation

1994 • 15 citations

Genetic analysis of pattern formation in the zebrafish neural plate.

1997 • 14 citations

Indicators of the dorsoventral axis in medaka (Oryzias latipes) zygotes

1995 • 12 citations

Inhibitory interactions controlling organizer activity in fish.

1996 • 4 citations

Pattern Formation during Development.

1999 • 3 citations