Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats.

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

The Blood-Testis Barrier in the Rat and the Physiological Compartmentation of the Seminiferous Epithelium1

1970 • 1,119 citations

Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues

1983 • 419 citations

Peptide Drug Delivery to the Brain

1992 • 309 citations

Molecular Anatomy of the Blood-Brain Barrier as Defined by Immunocytochemistry

1991 • 240 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier

1981 • 219 citations

High-Dose Oral Tamoxifen, a Potential Multidrug-Resistance-Reversal Agent: Phase I Trial in Combination With Vinblastine

1992 • 209 citations

Clinical Correlates of MDR1 (P-glycoprotein) Gene Expression in Ovarian and Small-Cell Lung Carcinomas

1992 • 183 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues.

1984 • 182 citations

Comparative pharmacokinetics of daunomycin and adriamycin in several animal species.

1972 • 164 citations

The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats

1987 • 139 citations

Do anticancer agents reach the tumor target in the human brain?

1992 • 133 citations

Toremifene: pharmacologic and pharmacokinetic basis of reversing multidrug resistance.

1989 • 92 citations

Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein

1994 • 78 citations

The determination of platinum in biological materials by electrothermal atomic absorption spectroscopy

1987 • 52 citations

Effects of verapamil on the pharmacokinetics of daunomycin in the rat

1987 • 36 citations

Horseradish peroxidase retention and washout in blood-brain barrier lesions

1992 • 26 citations

Cerebrospinal fluid collection in rats: modification of a previous technique.

1994 • 24 citations

Tissue disposition of doxorubicin in experimental animals

1982 • 23 citations

Determination of adriamycin in plasma and tissue biopsies

1991 • 20 citations

MDR-1 gene expression, anthracycline retention and cytotoxicity in human lung-tumor cells from refractory patients

1993 • 17 citations

The Role of Chemotherapy in the Treatment of Primary Tumors of the Central Nervous System

1994 • 17 citations

Effects of in vivo cyclosporine administration on endothelium-dependent responses in isolated vascular rings.

1992 • 15 citations

Opening of the Barrier in Cerebral Pathology

1992 • 9 citations