The Role of Chemotherapy in the Treatment of Primary Tumors of the Central Nervous System

— Tumors of the Central Nervous System

2013 • 1,787 citations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

Surgical Pathology of the Nervous System and its Coverings

2003 • 934 citations

Grading of astrocytomas: A simple and reproducible method

1988 • 902 citations

Primary central nervous system lymphoma

1988 • 811 citations

The treatment of medulloblastoma

1990 • 584 citations

Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas

1991 • 485 citations

Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma

1989 • 455 citations

Stereotactic Histologic Correlations of Computed Tomography- and Magnetic Resonance Imaging-Defined Abnormalities in Patients With Glial Neoplasms

1987 • 404 citations

Adjuvant chemotherapy for medulloblastoma: The first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I)

1990 • 400 citations

Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarrazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report

1990 • 399 citations

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

1983 • 394 citations

Successful chemotherapy for recurrent malignant oligodendroglioma

1988 • 346 citations

Oligodendrogliomas: the Mayo Clinic experience

1992 • 303 citations

Increasing Annual Incidence of Primary Malignant Brain Tumors in the Elderly

1990 • 266 citations

Grading of gliomas.

1950 • 229 citations

The role of radiation therapy in the treatment of astrocytomas

1975 • 226 citations

Eight drugs in one day chemotherapy for brain tumors: experience in 107 children and rationale for preradiation chemotherapy.

1987 • 220 citations

The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers

1992 • 215 citations

»GRADING« OF GLIOMAS

1950 • 203 citations

Intracranial ependymomas in children

1990 • 174 citations

Intravenous carboplatin for recurrent malignant glioma: a phase II study.

1991 • 173 citations

Therapeutic Efficacy of Multiagent Chemotherapy with Drug Delivery Enhancement by Blood-Brain Barrier Modification in Glioblastoma

1986 • 166 citations

Ependymomas and ependymoblastomas in children

1976 • 151 citations

Successful chemotherapy for newly diagnosed aggressive oligodendroglioma

1990 • 136 citations

Oligodendrogliomas I. A clinical study of cerebral oligodendrogliomas

1980 • 125 citations

Recurrent intracranial ependymomas in children survival, patterns of failure, and prognostic factors

1990 • 124 citations

S‐phase fraction of human brain tumors in situ measured by uptake of bromodeoxyuridine

1986 • 123 citations

Medulloblastoma in adults: A review of 47 patients treated between 1952 and 1981

1990 • 117 citations

Phase III comparison of BCNU and the combination of procarbazine, CCNU, and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas

1985 • 115 citations

Cisplatin in the treatment of recurrent childhood primary brain tumors.

1988 • 112 citations

Single-Agent Chemotherapy of Brain Tumors

1976 • 110 citations

Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma

1991 • 108 citations

Pharmacokinetics of intracarotid artery 14C-BCNU in the squirrel monkey

1978 • 101 citations

Oligodendroglioma: An analysis of the value of radiation therapy

1987 • 100 citations

Drug streaming during intra-arterial chemotherapy

1986 • 99 citations

Radiation therapy in the treatment of childhood astrocytic gliomas

1973 • 97 citations

Procarbazine hydrochloride in the treatment of brain tumors

1974 • 96 citations

The change in patterns of relapse in medulloblastoma

1991 • 93 citations

Radiation therapy of tumors of the central nervous system in childhood

1975 • 93 citations

Polymers to treat brain tumours

1990 • 92 citations

Phase II study of procarbazine, CCNU, and vincristine combination chemotherapy in the treatment of malignant brain tumors

1975 • 88 citations

Medulloblastoma: freedom from relapse longer than 8 years — a therapeutic cure?

1991 • 88 citations

Intracarotid cisplatin chemotherapy for recurrent gliomas

1989 • 88 citations

Radiation therapy in the treatment of meningioma: the Joint Center for Radiation Therapy experience 1970 to 1982.

1984 • 86 citations

Chemotherapy of brain metastases: Current status

1984 • 84 citations

Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors

1989 • 83 citations

Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine

1990 • 80 citations

5-Fluorouracil and 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Followed by Hydroxyurea, Misonidazole, and Irradiation for Brain Stem Gliomas: A Pilot Study of the Brain Tumor Research Center and the Childrens Cancer Group

1984 • 79 citations

Intra-arterial cisplatin for the treatment of malignant gliomas

1989 • 75 citations

Radiotherapy for high grade gliomas

1990 • 75 citations

Capillary permeability factor secreted by malignant brain tumor

1990 • 70 citations

Medulloblastoma—Prognostic Factors and Outcome of Treatment: Review of the Mayo Clinic Experience

1990 • 69 citations

Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: A pathological study

1989 • 68 citations

Treatment of recurrent malignant supratentorial gliomas with carboplatin (CBDCA)

1991 • 67 citations

Quality of survival of patients with brain gliomas treated with postoperative CCNU and radiation therapy

1989 • 65 citations

Chemotherapy of recurrent medulloblastoma with combined procarbazine, CCNU, and vincristine

1978 • 65 citations

Phase II study of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) in the treatment of brain tumors.

1972 • 63 citations

Intravascular streaming during carotid artery infusions

1991 • 62 citations

Therapeutic Considerations in Tumors Affecting the Central Nervous System: Oligodendrogliomas

1964 • 61 citations

Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation.

1987 • 59 citations

Cancer in Children: Clinical Management

1976 • 57 citations

Treatment of patients with recurrent primary brain tumors with AZQ

1984 • 56 citations

Pharmacokinetics of tumor cell exposure to [14C]methotrexate after intracarotid administration without and with hyperosmotic opening of the blood-brain and blood-tumor barriers in rat brain tumors: a quantitative autoradiographic study.

1988 • 56 citations

Intracarotid Chemotherapy with a Combination of 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU), cis-Diaminedichloroplatinum (Cisplatin), and 4′-O-Demethyl-1-O-(4,6-O-2-thenylidene-β-D-glucopyranosyl)epipodophyllotoxin (VM-26) in the Treatment of Primary and Metastatic Brain Tumors

1984 • 55 citations

Quantitative Aspects of Contrast Enhancement in Cranial Computed Tomography

1978 • 53 citations

Methotrexate neurotoxicity: in vitro studies using cerebellar explants from rats.

1989 • 51 citations

Delayed high iodine dose contrast computed tomography: cranial neoplasms.

1980 • 48 citations

Primary Intracranial Neoplasms

1957 • 45 citations

Combination chemotherapy with MOPP in children with recurrent brain tumors

1978 • 43 citations

Treatment of Recurrent Gliomas with 1,3-Bis(2-Chloroethyl)-1-Nitrosourea and A-Difluoromethylornithine

1989 • 41 citations

Adjuvant intraarterial chemotherapy with nimustine in the management of world health organization grade IV gliomas of the brain. Experience at the department of neurosurgery of Düsseldorf university

1989 • 39 citations

Protocol for delayed contrast enhancement in computed tomography of cerebral neoplasia.

1981 • 35 citations

Efficacy of postoperative chemotherapy using cisplatin plus etoposide in young children with brain tumors

1991 • 34 citations

High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma: A case report

1990 • 34 citations

PCNU treatment for recurrent malignant gliomas.

1984 • 33 citations

Phase II treatment of central nervous system gliomas with high-dose etoposide and autologous bone marrow transplantation.

1987 • 32 citations

Cisplatin, ara-C and etoposide (PAE) in the treatment of recurrent childhood brain tumors

1991 • 31 citations

Mechlorethamine, vincristine, and procarbazine chemotherapy for recurrent high-grade glioma in adults: a phase II study.

1990 • 30 citations

O6-Alkylguanine-DNA alkyltransferase activity in human brain tumors

1990 • 30 citations

Relationship of Cancer and Aging

1987 • 30 citations

“Eight-drugs-in-one-day” chemotherapy administered before and after radiotherapy to adult patients with malignant gliomas

1989 • 26 citations

12 Down, 36 To Go Francis Vian (ed., tr.): Nonnos de Panopolis, Les Dionysiaques, Tome IX: Chants XXV–XXIX. Texte établi et traduit. (Collection Budé.) Pp. xiii + 370 (73 double). Paris: Les Belles Lettres, 1990.

1992 • 25 citations

A randomized study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytoma

1989 • 24 citations

Familial clustering of malignant astrocytomas

1990 • 24 citations

Activity and toxicity of carboplatin and iproplatin in relapsed high-grade glioma

1991 • 22 citations

Vm-26 monochemotherapy trial in the treatment of recurrent supratentorial gliomas: Preliminary report

1981 • 20 citations

Intravenous BCNU and AZQ in patients with recurrent malignant gliomas

1989 • 20 citations

High Dose Chemotherapy with Autologous Bone Marrow Rescue for High Grade Gliomas of the Brain: A Potential for Improvement in Therapeutic Results

1984 • 19 citations

Uniformity of intracarotid drug distribution with diastole-phased pulsed infusion

1987 • 19 citations

Postoperative radical radiotherapy with concurrent weekly intra-arterial cis-platinum for treatment of malignant glioma: a pilot study

1989 • 18 citations

Eight‐drugs‐in‐one‐day chemotherapy in postirradiated adult patients with malignant gliomas

1989 • 17 citations

The Intraarterial Route of Drug Delivery in the Chemotherapy of Malignant Brain Tumours

1988 • 15 citations

Phase II study of aziridinylbenzoquinone (AZQ) in patients with central nervous system malignancies: a Southwest Oncology Group study

1985 • 15 citations

Rationale and techniques for intravenous enhancement in computed tomography.

1982 • 9 citations

Temporal Course of Contrast Medium Enhancement in Differential Diagnosis of Intracranial Lesions with Computer Tomography

1975 • 8 citations

Phase II Trial of Spirogermanium and Vindesine in Malignant Glioma

1989 • 6 citations

Phase II study of spirohydantoin mustard for the treatment of recurrent malignant gliomas.

1987 • 6 citations

Preliminary data by cis-platin and etoposide using in primary glioblastoma.

1990 • 2 citations