Opening of the Barrier in Cerebral Pathology

Angiogenic Factors

1987 • 3,702 citations

Astrocytes induce blood–brain barrier properties in endothelial cells

1987 • 1,593 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

Superoxide production in experimental brain injury

1986 • 420 citations

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

1970 • 371 citations

BLOOD-BRAIN BARRIER

1943 • 356 citations

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

1985 • 354 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

Pathophysiological Aspects of Brain Edema

1972 • 322 citations

New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury

1990 • 213 citations

Production and effects of platelet-activating factor in the rat brain

1988 • 205 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease

1986 • 192 citations

Altered angioarchitecture in selected areas of brains with Alzheimer's disease

1990 • 176 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

Induction of γ-glutamyl transpeptidase in cultured cerebral endothelial cells by a product released by astrocytes

1987 • 164 citations

Ultracytochemical characterization of anionic sites in the wall of brain capillaries

1989 • 154 citations

A quantitative analysis of blood-brain barrier ultrastructure in the aging human

1987 • 138 citations

Influence of long-term acute heat exposure on regional blood-brain barrier permeability, cerebral blood flow and 5-HT level in conscious normotensive young rats

1987 • 125 citations

Increased leukotriene C₄ and vasogenic edema surrounding brain tumors in humans

1986 • 123 citations

The role of arachidonic acid in vasogenic brain edema.

1984 • 111 citations

Epilepsy and the blood-brain barrier.

1986 • 108 citations

Further characterization of malignant glioma-derived vascular permeability factor

1988 • 107 citations

Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid

1987 • 107 citations

Quantitative study of microvessel ultrastructure in human peritumoral brain tissue

1987 • 107 citations

Examination of Blood — Brain Barrier Permeability in Dementia of the Alzheimer Type with [⁶⁸Ga]EDTA and Positron Emission Tomography

1987 • 104 citations

Mediators of brain edema and secondary brain damage

1988 • 101 citations

Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia

1988 • 97 citations

The kallikrein-kinin system as mediator in vasogenic brain edema

1986 • 95 citations

A quantitative study of blood-brain barrier permeability ultrastructure in a new rat glioma model

1985 • 93 citations

Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model

1986 • 90 citations

The vasculature of experimental brain tumours

1981 • 86 citations

Effect of captopril (a converting enzyme inhibitor) on blood-brain barrier permeability and cerebral blood flow in normotensive rats

1987 • 86 citations

The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors.

1976 • 83 citations

Serum amyloid P immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's disease

1990 • 82 citations

THE DEVELOPMENT AND ULTRASTRUCTURE OF THE MICROVASCULATURE IN MALIGNANT GLIOMAS

1977 • 81 citations

Regional Blood Flow and Blood-to-Tissue Transport in Five Brain Tumor Models

2015 • 78 citations

Three‐dimensional reconstruction of vesicles in endothelium of blood‐brain barrier versus highly permeable microvessels

1986 • 78 citations

Immunohistochemical demonstration of serum proteins in human cerebral gliomas

1987 • 78 citations

The Kallikrein-Kinin-System as Mediator in Vasogenic Brain Oedema

1983 • 74 citations

Response of cerebral microvasculature to brain injury

1988 • 73 citations

Effects of p-chlorophenylalanine on microvascular permeability changes in spinal cord trauma

1990 • 71 citations

Rapid increase in blood-brain barrier permeability during severe hypoxia and metabolic inhibition

1986 • 71 citations

Macrophage Infiltration Into Experimental Brain Metastases: Occurrence Through an Intact Blood-Brain Barrier

1988 • 66 citations

Microvascular abnormalities in ethylnitrosourea (ENU)-induced rat brain tumors: Structural basis for altered blood-brain barrier function

1983 • 66 citations

The vasculature of experimental brain tumours

1981 • 65 citations

Dimethylthiourea Reduces Ischemic Brain Edema without Affecting Cerebral Blood Flow

1990 • 63 citations

The vasculature of experimental brain tumours

1984 • 59 citations

Supravital Analysis of Disorders in the Cerebral Vascular Permeability in Man

1944 • 58 citations

EEG changes following increased blood-brain barrier permeability under long-term immobilization stress in young rats

1988 • 57 citations

Lack of evidence for dysfunction of the blood-brain barrier in Alzhiemer's disease: An immunohistochemical study

1988 • 52 citations

Electron microscopic study of the blood-brain barrier in rats with brain edema and encephalopathy due to acute hepatic failure

1989 • 51 citations

Revised Pathophysiology on BBB Damage: The Edema as an Ingeniously Provided Condition for Cell Motility and Lesion Repair

1983 • 48 citations

Intracarotid infusions of protamine sulfate disrupt the blood-brain barrier of rabbits

1987 • 47 citations

Effect of arachidonic acid on cultured cerebromicrovascular endothelium: permeability, lipid peroxidation and membrane ?fluidity?

1989 • 47 citations

The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability

1987 • 46 citations

EFFECTS OF PRENATAL ETHANOL EXPOSURE ON PHYSICAL GROWTH, SENSORY REFLEX MATURATION AND BRAIN DEVELOPMENT IN THE RAT

1986 • 44 citations

Permeability of human brain tumor to 99mTc-glucoheptonate and 99mTc-albumin

1986 • 44 citations

The influence of nimodipine on cerebral blood flow autoregulation and blood-brain barrier

1988 • 43 citations

In vivo imaging of intracranial human glioma xenografts comparing specific with nonspecific radiolabeled monoclonal antibodies

1986 • 41 citations

Morphofunctional Aspects of the Normal and Pathological Blood-Brain Barrier

1983 • 41 citations

Photochemically stimulated blood-borne factors induce blood-brain barrier alterations in rats.

1988 • 40 citations

Cerebral circulatory and metabolic effects of perivascular neurotransmitters.

1987 • 40 citations

Effects of free radicals on permeability and vasomotor response of cerebral vessels

1988 • 37 citations

Influence of ischemia on the passage of protein tracers across capillaries in certain blood-brain barrier injuries

1971 • 37 citations

Effect of aminophylline on postischemic edema and brain damage in cats.

1988 • 37 citations

Cerebral endothelial plasma membrane alterations in acute hypertension

1986 • 36 citations

The fine structure of vascular-astroglial relations in transplanted fetal neocortex

1989 • 36 citations

Sequelae of the osmotic blood-brain barrier opening in rats

1988 • 36 citations

Examination of the Blood-to-Brain Transfer of α-Aminoisobutyric Acid and Horseradish Peroxidase: Regional Alterations in Blood—Brain Barrier Function following Acute Hypertension

1986 • 35 citations

A UNIFYING CONCEPT ON THE PATHOGENESIS OF BRAIN OEDEMAS

1987 • 35 citations

Polyamines and Ca²⁺ Mediate Hyperosmolal Opening of the Blood‐Brain Barrier: In Vitro Studies in Isolated Rat Cerebral Capillaries

1989 • 35 citations

Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: effects of unilateral locus ceruleus lesion

1987 • 34 citations

High voltage electron microscopic studies of endothelial cell tubular structures in the mouse blood-brain barrier following brain trauma

1989 • 30 citations

Permeability of blood vessels in experimental gliomas: uptake of 99mTc-glucoheptonate and alteration in blood-brain barrier as determined by cytochemistry and electron microscopy.

1989 • 30 citations

Astrocytic orthogonal arrays of intramembranous particle assemblies are modulated by brain endothelial cellsin vitro

1990 • 28 citations

Neurotoxicity of adriamycin passed through the transiently disrupted blood-brain barrier by mannitol in the rat brain

1987 • 28 citations

Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexamethasone

1989 • 26 citations

Cellular glycoconjugates and their potential endogenous receptors in the cerebral microvasculature of man: a glycohistochemical study.

1988 • 26 citations

A MORPHOMETRIC STUDY OF THE MICROVASCULATURE OF A RAT GLIOMA

1985 • 25 citations

The permeability to small ions of tight junctions between cerebral endothelial cells

1974 • 24 citations

On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease

1988 • 24 citations

Adrenaline-induced hypertension: morphological consequences of the blood-brain barrier disturbance

1988 • 23 citations

The vasculature of experimental brain tumours

1984 • 21 citations

Glial Cells in the Rat Optic Nerve and Some Thoughts on Remyelination in the Mammalian Cns

1987 • 21 citations

Vasoactive drugs produce selective changes in flow to experimental brain tumors

1985 • 21 citations

Lymphocyte infiltration into normal rat brain following hyperosmotic blood-brain barrier opening

1990 • 21 citations

Distribution of anionic sites on the capillary endothelium in an experimental brain tumor model.

1988 • 19 citations

Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability

1989 • 17 citations

Cerebral vessels cryofixed after hyperosmosis or cold injury in normothermic and hypothermic frogs

1988 • 16 citations

The effect of dexamethasone on vascular permeability of experimental brain tumours

1986 • 15 citations

Systemic Focal Epileptogenesis

1986 • 15 citations

Permeability of Blood Vessels in Experimental Gliomas: Uptake of 99mTc-Glucoheptonate and Alteration in Blood-Brain Barrier as Determined by Cytochemistry and Electron Microscopy

1989 • 15 citations

THE EFFECT OF A METABOLIC INHIBITOR UPON THE PROPERTIES OF THE CEREBRAL VASCULATURE DURING A WHOLE‐HEAD SALINE PERFUSION OF THE RAT

1987 • 14 citations

Blood-Brain Barrier Permeability of Human Gliomas as Determined by Quantitation of Cytoplasmic Vesicles of the Capillary Endothelium and Scintigraphic Findings

1989 • 13 citations

Steroids in diseases of the central nervous system

1991 • 12 citations

The Cerebrovascular Effects of Curare and Histamine in the Rat

1987 • 12 citations

Ultrastructural observations of spinal cord lesions and blood-brain barrier changes in scrapie-infected mice

1987 • 12 citations

The Effect of a Low pH Saline Perfusate upon the Integrity of the Energy-Depleted Rat Blood-Brain Barrier

1989 • 11 citations

Mechanism of action of collagenase on the blood-brain barrier permeability. Increase of endothelial cell pinocytotic activity as shown with horse-radish peroxidase as a tracer

1979 • 11 citations

No evidence for involvement of plasma proteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice

1987 • 10 citations

α1-Adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations: preservation in multi-infarct dementia and dementia of Alzheimer typereceptor binding sites in post-mortal human cerebral microvessel preparations: preservation in multi-infarct dementia and dementia of Alzheimer type

1989 • 10 citations

The Pathology of the Amyloid A4 Precursor of Alzheimer's Disease

1989 • 9 citations

Reverse pinocytosis induced in cerebral endothelial cells by injection of histamine into the cerebral ventricle

1988 • 8 citations

Glial Brain Tumors Lack Microvascular Adrenergic Receptors

1988 • 6 citations

VASCULAR PERMEABILITY IN TRANSPLANTABLE MURINE GLIOMAS: MORPHOLOGICAL CORRELATION WITH TRACER STUDIES

1987 • 3 citations

The Effect of Modification of the Blood‐Brain Barrier to IgG on the Course of Murine Herpes Simplex Myelitis

1988 • 1 citations