Rat and Mouse Models of Hypovolemic-Traumatic Shock

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

Harrison's Principles of Internal Medicine

1988 • 1,293 citations

Multiple Organ Failure

1999 • 820 citations

[Multiple organ failure syndrome].

1988 • 795 citations

Multiple System Organ Failure

1980 • 751 citations

Experimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock)

1970 • 715 citations

Trauma

1983 • 599 citations

Trauma. Accidental and intentional injuries account for more years of life lost in the U.S. than cancer and heart disease. Among the prescribed remedies are improved preventive efforts, speedier surgery and further research.

1983 • 518 citations

Multiple Organ Failure in Polytrauma Patients

1983 • 492 citations

The Gut Origin Septic States in Blunt Multiple Trauma (ISS = 40) in the ICU

1987 • 352 citations

Current surgical diagnosis & treatment

1977 • 323 citations

Fluid therapy in hemorrhagic shock

1964 • 305 citations

Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock

1971 • 268 citations

Hemorrhage Without Tissue Trauma Produces Immunosuppression and Enhances Susceptibility to Sepsis

1987 • 220 citations

Remote organ failure: a valid sign of occult intra-abdominal infection.

1977 • 208 citations

Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation.

1988 • 207 citations

Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin

1990 • 186 citations

Microbial Infection and the Septic Response in Critical Surgical Illness

1990 • 160 citations

EXPERIMENTAL SHOCK

1930 • 157 citations

Cellular mechanisms in shock and ischemia and their correction

1983 • 153 citations

H+/base transport in principal cells characterized by confocal fluorescence imaging

1990 • 142 citations

Davis-Christopher Textbook of Surgery.

1978 • 137 citations

Limits of cardiac compensation in anemic baboons.

1988 • 133 citations

Posttraumatic Multisystem Organ Failure

1988 • 131 citations

Hemorrhage and resuscitation: immunological aspects

1990 • 126 citations

Effect of diabetes on Na(+)-H+ exchange by single isolated hepatocytes

1991 • 117 citations

THE PRESENT STATUS OF THE SHOCK PROBLEM

1942 • 114 citations

Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.

1990 • 95 citations

OCCURRENCE OF BACTEREMIA DURING AND AFTER HEMORRHAGIC SHOCK

1986 • 94 citations

Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation

1990 • 87 citations

Pentoxifylline restores intestinal microvascular blood flow during resuscitated hemorrhagic shock.

1991 • 86 citations

Evaluation of cardiac output, total peripheral vascular resistance, and plasma concentrations of vasopressin in the conscious, unrestrained rat during endotoxemia.

1985 • 85 citations

In Vivo Coagulation—a Probable Cause of Irreversible Shock

1955 • 82 citations

Reliability of the Determination of Cardiac Output in Man by Means of the Fick Principle

1958 • 82 citations

Crystalloid resuscitation restores but does not maintain cardiac output following severe hemorrhage

1991 • 75 citations

Adhesiveness of platelets and leukocytes during acute exsanguination

1962 • 74 citations

Christopher??s Textbook of Surgery.

1961 • 73 citations

Does the Bacteremia Observed in Hemorrhagic Shock Have Clinical Significance?

1989 • 71 citations

Effect of adenosine triphosphate-magnesium chloride administration in shock.

1974 • 70 citations

Occurrence of Bacteremia During and After Hemorrhagic Shock

1988 • 68 citations

Depressed antigen presentation function and membrane interleukin-1 activity of peritoneal macrophages after laparotomy.

1987 • 67 citations

Effect of Hemorrhagic Shock on Tissue Adenine Nucleotides in Conscious Rats

1974 • 67 citations

Multiple Organ Failure

1990 • 63 citations

Blockade of Prostaglandin Production Increases Cachectin Synthesis and Prevents Depression of Macrophage Functions After Hemorrhagic Shock

1991 • 62 citations

Ultrastructural Changes in Hemorrhagic Shock

1965 • 62 citations

The ‘Lung in Shock’ as a Result of Hypovolemic-Traumatic Shock in Baboons

1987 • 57 citations

THE TREATMENT OF SEVERE AND PROGRESSIVE HEMORRHAGE BY INTRAVENOUS INJECTIONS

1919 • 56 citations

Colonic Cl channel blockade by three classes of compounds

1991 • 55 citations

Effect of hemorrhagic shock on transmembrane potential.

1969 • 55 citations

The predisposition to infection following hemorrhagic shock.

1977 • 54 citations

MULTIPLE ORGAN FAILURE IN POLY-TRAUMA PATIENTS

1982 • 54 citations

Cellular transport defects in hemorrhagic shock.

1971 • 54 citations

HEMORRHAGIC HYPOTENSION AND ITS TREATMENT BY INTRA-ARTERIAL AND INTRAVENOUS INFUSION OF BLOOD

1943 • 53 citations

An experimental study of susceptibility to infection after hemorrhagic shock.

1989 • 53 citations

THE EFFECTS OF HEMORRHAGE ON TISSUE METABOLITES

1946 • 53 citations

Impact of a Comprehensive Supportive Care Team on Management of Hopelessly III Patients with Multiple Organ Failure

1989 • 52 citations

Mechanism of immunosuppression following hemorrhage: Defective antigen presentation by macrophages

1989 • 51 citations

Multiple Organ Failure: Patient Care and Prevention

1991 • 51 citations

Pathophysiology of Haemorrhagic Shock

1984 • 49 citations

Hemorrhage in mice induces alterations in immunoglobulin-secreting B cells

1989 • 47 citations

Vascular Reactions in the Small Intestine of the Cat during Hemorrhage

1973 • 46 citations

Adsequate Crystalloid Resuscitation Restores but Fails to Maintain the Active Hepatocellular Function Following Hemorrhagic Shock

1991 • 44 citations

Davis-Christopher Textbook of Surgery

1976 • 43 citations

Mitochondrial metabolism of succinate, beta-hydroxybutyrate, and alpha-ketoglutarate in hemorrhagic shock

1971 • 42 citations

Redistribution of blood flow after thermal injury and hemorrhagic shock

1988 • 40 citations

Alterations in high-energy phosphates in hemorrhagic shock as related to tissue and organ function.

1976 • 40 citations

Protective Effects of Preheparinization on the Microvasculature During and After Hemorrhagic Shock

1992 • 40 citations

Oxygen therapy in hemorrhagic shock.

1991 • 39 citations

Effect of hemoglobin concentration on critical cardiac output and oxygen transport

1989 • 38 citations

BIOCHEMICAL STUDIES ON SHOCK

1944 • 38 citations

Cellular Alterations With Shock and Ischemia

1974 • 37 citations

Transfusion therapy in emergency medicine

1988 • 36 citations

Current Surgical Diagnosis and Treatment

1987 • 35 citations

Hepatic ultrastructure in endotoxemia, hemorrhage, and hypoxia: emphasis on mitochondrial changes.

1973 • 33 citations

Insulin Resistance in Experimental Shock

1974 • 33 citations

Bone marrow failure after hemorrhagic shock.

1990 • 32 citations

Multiple organ failure: whole body inflammation?

1989 • 32 citations

ATP-MgCl2 restores the depressed hepatocellular function and hepatic blood flow following hemorrhage and resuscitation

1991 • 31 citations

STUDIES ON SHOCK INDUCED BY HEMORRHAGE: XI. A METHOD FOR THE ACCURATE CONTROL OF BLOOD PRESSURE

1945 • 31 citations

Localization of the energy pathway block in shock.

1968 • 30 citations

Irreversible hemorrhagic shock in rats: changes in blood glucose and liver glycogen

1961 • 29 citations

SALINE VENOUS INJECTION IN CASES OF MALIGNANT CHOLERA, PERFORMED WHILE IN THE VAPOUR-BATH.

1832 • 29 citations

Validity of thermodilution method for measurement of cardiac output in pulmonary oedema

1973 • 28 citations

BLOOD VOLUME IN EXPERIMENTAL HEMORRHAGIC SHOCK

1945 • 28 citations

Liver cell membrane alterations during hemorrhagic shock in the rat

1981 • 28 citations

Glucose uptake by diaphragms from rats subjected to hemorrhagic shock

1964 • 27 citations

Pathophysiology of hemorrhagic shock

1985 • 25 citations

Immunoprotective effect of a calcium channel blocker on macrophage antigen presentation function, major histocompatability class II antigen expression, and interleukin-1 synthesis after hemorrhage.

1990 • 25 citations

Some side effects of heparin, heparinoids, and their antagonists

1966 • 25 citations

Salutary consequences of blockade of platelet activating factor in hemorrhagic shock

1988 • 25 citations

Different response of hepatic energy change and adenine nucleotide concentrations to hemorrhagic shock

1976 • 24 citations

Experimental Acute Hemorrhage

1965 • 23 citations

Depressed Gut Absorptive Capacity Early After Trauma-Hemorrhagic Shock

1991 • 23 citations

The effect of ATP-MgCl2 infusion on hepatic cell permeability and metabolism after hemorrhagic shock.

1981 • 22 citations

Microcirculatory approach to the treatment of circulatory shock with a new analog of vasopressin, (2-phenylalanine, 8-ornithine)vasopressin.

1976 • 22 citations

The effects of the concentration and function of hemoglobin on the survival of rats after hemorrhage.

1979 • 21 citations

STANDARDIZATION OF EXPERIMENTAL HEMORRHAGIC SHOCK

1945 • 20 citations

Improved biological properties of synthetic distearoyl phosphatidyl choline-based liposome in the conscious rat.

1990 • 18 citations

BIOCHEMICAL CHANGES DURING ACUTE PHYSIOLOGICAL FAILURE IN THE RAT: II. THE BEHAVIOR OF ADENINE AND PYRIDINE NUCLEOTIDES OF THE LIVER DURING SHOCK

1964 • 18 citations

Effect of hemorrhagic shock on hepatic transmembrane potentials and intracellular electrolytes, in vivo

1981 • 18 citations

SALINE VENOUS INJECTION IN CASES OF MALIGNANT CHOLERA, PERFORMED WHILE IN THE VAPOUR-BATH.

1832 • 17 citations

DPAVP: A vasopressin analog with selective mcirovascular and res actions for the treatment of circulatory shock in rats

1976 • 17 citations

Hepatic denervation alters hemodynamic response to hemorrhage in conscious rats

1989 • 17 citations

Impairment of Cell Membrane Transport During Shock and after Treatment

1973 • 16 citations

THE STANDARDIZATION OF HEMORRHAGIC SHOCK IN THE RAT: OBSERVATIONS ON THE EFFECTS OF TRANSFUSIONS OF WHOLE BLOOD AND SOME BLOOD SUBSTITUTES

1946 • 16 citations

Diltiazem administration after crystalloid resuscitation restores active hepatocellular function and hepatic blood flow after severe hemorrhagic shock.

1991 • 16 citations

Decreased Fc Receptor Expression on Macrophages Following Simple Hemorrhage as Observed by Scanning Immunoelectron Microscopy

1990 • 15 citations

Beneficial actions of antagonism of peptide leukotrienes in hemorrhagic shock.

1988 • 14 citations

Insights into the mechanisms of defective antigen presentation after hemorrhage.

1991 • 14 citations

HEMORRHAGIC SHOCK: A METHOD FOR ITS PRODUCTION AND A FORMULA FOR PROGNOSIS

1945 • 13 citations

Measurement of cardiac output by the thermodilution method in conscious spontaneously hypertensive rats.

1984 • 12 citations

Prolonged hemorrhagic shock decreases splanchnic prostacyclin synthesis

1991 • 12 citations

THE MEASUREMENT OF BLEEDING VOLUME IN THE DOG FOR STUDIES ON BLOOD SUBSTITUTES

1943 • 11 citations

Pathophysiology of hemorrhagic shock. II. Anoxic metabolism of the rat liver following acute blood loss in the rat.

1981 • 11 citations

The Christopherʼs Textbook of Surgery

1965 • 11 citations

Metabolic factors associated with endotoxin-induced tolerance for hemorrhagic shock.

1968 • 10 citations

Effects of hemorrhagic shock on nuclear DNA.

1979 • 10 citations

Preoptic hypothalamic lesions reduce adrenergic vascular compensation during hemorrhagic shock.

1990 • 10 citations

Metabolic and ionic changes in muscle during hemorrhagic shock.

1988 • 10 citations

A nonheparinized muscle model for studies of ischemia-reperfusion injury

1986 • 9 citations

Effect of Glucagon and Blood Transfusion on Liver Metabolism in Hemorrhagic Shock

1978 • 9 citations

Metabolism of adenine nucleotides in the kidney during hemorrhagic hypotension and after recovery

1980 • 9 citations

Beneficial effects of diltiazem in hemorrhagic shock.

1991 • 8 citations

Normotoner h�morrhagischer Schock

1968 • 8 citations

Heparin pretreatment suppresses norepinephrine concentrations in dogs in endotoxic shock.

1977 • 8 citations

Measurement of D-xylose gut absorptive capacity in conscious rats

1991 • 8 citations

Microvascular responses of intact and adrenal medullectomized rats to hemorrhagic shock.

1988 • 8 citations

A method for hemorrhagic shock in the rat

1987 • 8 citations

Comparative evaluation of the effects of felodipine, hydralazine, and naloxone on the survival rate in rats subjected to a "fixed volume" model of hemorrhagic shock.

1990 • 7 citations

MORTALITY AND RENAL TUBULAR NECROSIS IN HEMORRHAGIC SHOCK IN DOGS: THE EFFECT OF BLOOD HANDLING.

1963 • 6 citations