Osmotic Stimulation of the Na+/H+ Exchanger NHE1: Relationship to the Activation of Three MAPK Pathways

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

The stress-activated protein kinase pathways

1999 • 648 citations

Molecular physiology of vertebrate Na+/H+ exchangers

1997 • 624 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Regulation of Cell Volume in Health and Disease

1995 • 450 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms

1995 • 394 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

1992 • 223 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils

1997 • 184 citations

The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors

1997 • 182 citations

Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways

1996 • 171 citations

Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

1997 • 154 citations

Long-term expression of c-H-ras stimulates Na-H and Na(+)-dependent Cl-HCO3 exchange in NIH-3T3 fibroblasts.

1994 • 85 citations

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress

1995 • 79 citations

Topological analysis of NHE1, the ubiquitous Na⁺/H⁺exchanger using chymotryptic cleavage

1998 • 72 citations

Cytosolic Alkalinization Increases Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase (SAPK/JNK) Activity and p38 Mitogen-activated Protein Kinase Activity by a Calcium-independent Mechanism

1997 • 55 citations

Ha-ras activates the Na+/H+ antiporter by a protein kinase C-independent mechanism

1989 • 46 citations

Assessment of Na+-H+ exchange activity in phagosomal membranes of human neutrophils

1988 • 34 citations

Clonal Nature of Spontaneously Immortalized 3T3 Cells

1996 • 17 citations

Rapid increase in pH set-point of the Na+-in-dependent chloride/bicarbonate antiporter in vero cells exposed to heat shock

1993 • 15 citations

Interleukin-1 enhances beta-responsiveness of cardiac L-type calcium current suppressed by acidosis

1994 • 11 citations

Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation

1992 • 5 citations

Differences Between Shrinkage-Induced Activation of Na + /H + Exchange in C6 Glioma Cells and Neutrophils

1999 • 1 citations