Protein kinase C phosphorylation of cardiac troponin T decreases Ca2+-dependent actomyosin MgATPase activity and troponin T binding to tropomyosin-F-actin complex

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

1979 • 1,648 citations

[18] Purification of muscle actin

1982 • 1,186 citations

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

1987 • 529 citations

Thin Filament Proteins and Thin Filament-Linked Regulation of Vertebrate Muscle Contractio

1984 • 409 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

[22] Preparation of troponin and its subnits

1982 • 345 citations

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

1985 • 305 citations

Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake.

1984 • 255 citations

Phorbol ester increases calcium current and simulates the effects of angiotensin II on cultured neonatal rat heart myocytes.

1988 • 245 citations

Thermodynamic Studies of the Formation and Ionization of the Magnesium(II) Complexes of ADP and ATP over the pH Range 5 to 9¹

1966 • 226 citations

Troponin I Switching in the Developing Heart

1989 • 212 citations

Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid.

1983 • 207 citations

The MgATP-Dependent Protein Phosphatase and Protein Phosphatase 1 Have Identical Substrate Specificities

2005 • 191 citations

Kinetics of the interaction between actin, ADP, and cardiac myosin-S1.

1984 • 187 citations

Isolation and functional comparison of bovine cardiac troponin T isoforms.

1987 • 164 citations

Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.

1990 • 159 citations

Synthetic studies on the inhibitory region of rabbit skeletal troponin I. Relationship of amino acid sequence to biological activity.

1981 • 145 citations

Phorbol ester and dioctanoylglycerol stimulate membrane association of protein kinase C and have a negative inotropic effect mediated by changes in cytosolic Ca2+ in adult rat cardiac myocytes.

1990 • 140 citations

Tumor-promoting phorbol esters inhibit cardiac functions and induce redistribution of protein kinase C in perfused beating rat heart.

1987 • 139 citations

Phosphorylation of cardiac troponin inhibitory subunit (troponin I) and tropomyosin-binding subunit (troponin T) by cardiac phospholipid-sensitive Ca2+-dependent protein kinase

1983 • 139 citations

Physiology and Pathophysiology of the Heart

1990 • 137 citations

Phosphorylation of cardiac troponin by guanosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 134 citations

Calcium-Induced Movement of Troponin-I Relative to Actin in Skeletal Muscle Thin Filaments

1990 • 131 citations

The effects of troponin T fragments T1 and T2 on the binding of nonpolymerizable tropomyosin to F-actin in the presence and absence of troponin I and troponin C.

1987 • 129 citations

Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites

1989 • 126 citations

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart.

1986 • 114 citations

The biological importance of each amino acid residue of the troponin I inhibitory sequence 104-115 in the interaction with troponin C and tropomyosin-actin.

1988 • 113 citations

Changes in myofibrillar activation and troponin C Ca2+ binding associated with troponin T isoform switching in developing rabbit heart.

1990 • 113 citations

Chemical properties, isolation, and analysis of O-phosphates in proteins

1984 • 111 citations

Molecular cloning of rat cardiac troponin I and analysis of troponin I isoform expression in developing rat heart

1991 • 109 citations

Protein kinase C phosphorylation of cardiac troponin I or troponin T inhibits Ca2(+)-stimulated actomyosin MgATPase activity.

1991 • 106 citations

Rapid purification of mammalian cardiac troponin T and its isoform switching in rat hearts during development.

1988 • 99 citations

Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. Differential inhibition of protein kinase C, Ca2+/calmodulin-dependent protein kinase II and synaptosomal membrane Na,K-ATPase, and Na+ pump and differentiation of HL60 cells.

1991 • 95 citations

Troponin T switching in the developing rat heart.

1988 • 92 citations

Protein kinase C inhibits Ca2+ accumulation in cardiac sarcoplasmic reticulum.

1990 • 90 citations

Effect of protein kinase C activation on sarcoplasmic reticulum function and apparent myofibrillar Ca2+ sensitivity in intact and skinned muscles from normal and diseased human myocardium.

1990 • 84 citations

Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes

1991 • 82 citations

Calcium binding to the low affinity sites in troponin C induces conformational changes in the high affinity domain. A possible route of information transfer in activation of muscle contraction.

1986 • 80 citations

Bovine cardiac troponin T: amino acid sequences of the two isoforms

1987 • 78 citations

Amino acid sequence of bovine cardiac troponin I

1988 • 78 citations

Phosphorylation of contractile proteins in relation to muscle function.

1980 • 77 citations

Effects of phosphorylated and unphosphorylated C-protein on cardiac actomyosin ATPase

1985 • 74 citations

Phospholamban and troponin I are substrates for protein kinase C in vitro but not in intact beating guinea pig hearts.

1990 • 74 citations

Identification and pattern of expression of a developmental isoform of troponin I in chicken and rat cardiac muscle

1989 • 71 citations

Protein phosphorylation in heart muscle

1986 • 69 citations

Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells

1987 • 69 citations

Effect of alpha-adrenergic stimulation on activation of protein kinase C and phosphorylation of proteins in intact rabbit hearts.

1992 • 65 citations

Sites phosphorylated in bovine cardiac troponin T and I

1990 • 60 citations

Interaction of tropomyosin-troponin with actin filaments

1981 • 60 citations

Synthesis and biological activity of an icosapeptide analog of the actomyosin ATPase inhibitory region of troponin I.

1979 • 53 citations

Some properties of cardiac troponin T structure

1983 • 48 citations

Subcellular distribution and immunocytochemical localization of protein kinase C in myocardium, and phosphorylation of troponin in isolated myocytes stimulated by isoproterenol or phorbol ester

1989 • 47 citations

Phosphorylation of skeletal-muscle troponin I and troponin T by phospholipid-sensitive Ca2+-dependent protein kinase and its inhibition by troponin C and tropomyosin

1984 • 46 citations

Concentration-dependent effects of protein kinase C-activating and -nonactivating phorbol esters on myocardial contractility, coronary resistance, energy metabolism, prostacyclin synthesis, and ultrastructure in isolated rat hearts. Effects of amiloride.

1991 • 41 citations

Comparison of the structure of two cardiac troponin T isoforms

1985 • 34 citations

Mechanisms for cardiac depression induced by phorbol myristate acetate in working rat hearts

1990 • 30 citations

Acute α1-adrenergic stimulation of cardiac protein synthesis may involve increased intracellular pH and protein kinase activity

1991 • 23 citations

Cooperative interactions between troponin molecules bound to the cardiac thin filament.

1991 • 21 citations