Analysis of major histocompatibility complex class I expression on Reed- Sternberg cells in relation to the cytotoxic T-cell response in Epstein- Barr virus-positive and -negative Hodgkin's disease

Report of the Committee on Hodgkin's Disease Staging Classification.

1971 • 4,212 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.

1992 • 519 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells.

1991 • 415 citations

Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development.

1992 • 402 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.

1993 • 368 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.

1994 • 314 citations

Impaired Lymphocyte Function in Untreated Hodgkin's Disease

1974 • 294 citations

HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in Western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy

1990 • 252 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma

1993 • 217 citations

Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein‐Barr virus latent membrane protein‐1: coordinate up‐regulation of peptide transporters and HLA‐class I antigen expression

1995 • 205 citations

HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2

1993 • 191 citations

Cytokines in the generation of immune responses to, and resolution of, virus infection

1994 • 185 citations

Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease

1994 • 175 citations

Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease

1995 • 175 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Autologous Mixed Lymphocyte Reaction in Patients with Hodgkin's Disease

1980 • 126 citations

Epstein-Barr virus: adaptation to a life within the immune system

1994 • 122 citations

Type 2 cytokines and negative immune regulation in human infections

1993 • 105 citations

Epstein-Barr virus (EBV)-encoded membrane protein LMP1 from a nasopharyngeal carcinoma is non-immunogenic in a murine model system, in contrast to a B cell-derived homologue

1994 • 103 citations

HLA class II antigen expression in human papillomavirus-associated cervical cancer.

1992 • 97 citations

A highly sensitive one-step method for silver intensification of the nickel-diaminobenzidine endproduct of peroxidase reaction.

1989 • 91 citations

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins

1993 • 86 citations

The impact of Hodgkin's disease on the immune system.

1990 • 84 citations

Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.

1987 • 82 citations

Cellular studies on antigen presentation by class II MHC molecules

1992 • 75 citations

Expression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells independent of presence of Epstein-Barr virus.

1993 • 70 citations

L-428 nodular sclerosing Hodgkin's cell secretes a unique transforming growth factor-beta active at physiologic pH.

1988 • 69 citations

Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood

1995 • 64 citations

Absence of HLA class I expression by Reed-Sternberg cells.

1994 • 63 citations

Association of an interleukin abnormality with the T cell defect in Hodgkin's disease

1984 • 56 citations

Human and viral interleukin‐10 in Hodgkin's disease, and its influence on CD4⁺ and CD8⁺ T lymphocytes

1995 • 55 citations

A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.

1989 • 51 citations

Epstein–Barr virus in Hodgkin's disease

1996 • 40 citations

Antigen processing and presentation by EBV‐carrying cell lines: Cell‐phenotype dependence and influence of the EBV‐encoded LMP1

1993 • 35 citations

An antigen processing polymorphism revealed by HLA‐B8‐restricted cytotoxic T lymphocytes which does not correlate with TAP gene polymorphism

1993 • 33 citations

Immunohistochemical demonstration of different latent membrane protein-1 epitopes of Epstein-Barr virus in lymphoproliferative diseases.

1995 • 31 citations

Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.

1991 • 30 citations

Computer assisted efficiency testing of different sampling methods for selective nuclear graphic tablet morphometry.

1990 • 30 citations

Expression of bcl‐2 protein and transcription of the Epstein‐Barr virus bcl‐2 homologue BHRF‐1 in Hodgkin's disease: implications for different pathogenic mechanisms

1995 • 27 citations

Epstein-Barr virus burden in Hodgkin's disease is related to latent membrane protein gene expression but not to active viral replication

1992 • 21 citations