Expression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells independent of presence of Epstein-Barr virus.

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease

1989 • 917 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease

1991 • 718 citations

Molecular Analysis of the T(14;18) Chromosomal Translocation in Malignant Lymphomas

1987 • 701 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

1986 • 380 citations

Two human c-onc genes are located on the long arm of chromosome 8.

1982 • 329 citations

Early events in Epstein-Barr virus infection of human B lymphocytes

1991 • 297 citations

Expression of a Cellular Oncogene During Liver Regeneration

1983 • 281 citations

Activation of thec-mycOncogene in a Precursor-B-Cell Blast Crisis of Follicular Lymphoma, Presenting as Composite Lymphoma

1988 • 258 citations

High incidence of Epstein-Barr virus genomes in Hodgkin's disease.

1990 • 237 citations

V-myc- and c-myc-encoded proteins are associated with the nuclear matrix.

1985 • 222 citations

Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms

1991 • 174 citations

Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells.

1991 • 163 citations

Involvement of the bcl-2 Gene in Hodgkin's Disease

1990 • 126 citations

Expression of lymphoid‐associated antigens on Hodgkin's and Reed‐Sternberg cells of Hodgkin's disease. An immunocytochemical study on lymph node cytospins using monoclonal antibodies

1987 • 106 citations

Tumor cell growth fraction in Hodgkin's disease.

1987 • 77 citations

Oncogenes and anti‐oncogenes; the molecular basis of tumour behaviour

1991 • 70 citations

V-myc- and c-myc-Encoded Proteins Are Associated with the Nuclear Matrix

1985 • 69 citations

Epstein-Barr virus and lymphoproliferative disorders.

1988 • 67 citations

Tumor necrosis factor receptors in lymphoid tissues and lymphomas. Source and site of action of tumor necrosis factor alpha.

1991 • 56 citations

Absence of t(14;18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease.

1991 • 52 citations

A critical appraisal of the immunohistochemical detection of the c-myc oncogene product in colorectal cancer

1987 • 49 citations

Application and comparison of silver intensification methods for the diaminobenzidine and diaminobenzidine-nickel endproduct of the peroxidation reaction in immunohistochemistry and in situ hybridization.

1992 • 34 citations

Expression of Epstein-Barr virus latent gene products and related cellular activation and adhesion molecules in Hodgkin's disease and non-Hodgkin's lymphomas arising in patients without overt pre-existing immunodeficiency

1993 • 33 citations

The distribution of the c-myc oncogene product in malignant lymphomas and various normal tissues as demonstrated by immunocytochemistry

1986 • 33 citations

Expression ofc-myc Oncogens Product andras Family Oncogene Products in Various Human Malignant Lymphomas Defined by Immunohistochemical Techniques

1988 • 32 citations

Heparin-treated, v-myc-transformed chicken heart mesenchymal cells assume a normal morphology but are hypersensitive to epidermal growth factor (EGF) and brain fibroblast growth factor (bFGF); cells transformed by the v-Ha-ras oncogene are refractory to EGF and bFGF but are hypersensitive to insulin-like growth factors.

1985 • 31 citations

Multidisciplinary management of non-small cell lung cancer in the community.

1990 • 28 citations

Lymphocyte predominance Hodgkin's disease (nodular paragranuloma)–a bcl‐2 negative germinal centre lymphoma

1991 • 27 citations

Fine-Needle Aspiration of Non-Hodgkin's Lymphoma: Southern Blot Analysis for Antigen Receptor, bcl-2, and c-myc Gene Rearrangements

1990 • 25 citations

Epstein-Barr virus DNA in Reed-Sternberg cells of Hodgkin's disease is frequently associated with CR2 (EBV receptor) expression

1992 • 19 citations