Calcium Channel Blockers

Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis

1977 • 1,317 citations

Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage

1983 • 1,148 citations

Regulation and Kinetics of the Actin-Myosin-ATP Interaction

1980 • 1,077 citations

“Variant” angina: One aspect of a continuous spectrum of vasospastic myocardial ischemia

1978 • 935 citations

Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

1980 • 865 citations

Control of myocardial oxygen consumption

1971 • 799 citations

IMPACT OF SEXUAL AND PHYSICAL ABUSE ON WOMEN'S MENTAL HEALTH

1988 • 603 citations

Relation of Heart Rate and Systolic Blood Pressure to the Onset of Pain in Angina Pectoris

1967 • 563 citations

Diltiazem and Reinfarction in Patients with Non-Q-Wave Myocardial Infarction

1986 • 539 citations

Coronary-Artery Spasm

1978 • 508 citations

Action potentials, afterpotentials, and arrhythmias.

1977 • 474 citations

Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: An echocardiographic study

1980 • 407 citations

Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy.

1981 • 401 citations

Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man.

1982 • 331 citations

Response of recurrent sustained ventricular tachycardia to verapamil.

1981 • 327 citations

Immediate Effects of Intravenous Verapamil in Cardiac Arrhythmias

1972 • 311 citations

New Perspectives on Calcium Antagonists

1982 • 310 citations

Effects of Agents which Inhibit the Slow Channel on Sinus Node Automaticity and Atrioventricular Conduction in the Dog

1974 • 284 citations

Inhibition of Hypoxic Pulmonary Vasoconstriction by Nifedipine

1981 • 276 citations

Nifedipine therapy for patients with threatened and acute myocardial infarction: a randomized, double-blind, placebo-controlled comparison.

1984 • 274 citations

Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy.

1981 • 262 citations

Controlled Double-Blind Trial of Nifedipine in the Treatment of Raynaud's Phenomenon

1983 • 245 citations

Physiological disposition of verapamil in man

1976 • 244 citations

Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy.

1982 • 244 citations

Nifedipine in Unstable Angina

1982 • 237 citations

Therapeutic implications of slow-channel blockade in cardiocirculatory disorders.

1980 • 235 citations

Nifedipine in hypertensive emergencies.

1983 • 224 citations

Nifedipine: Kinetics and dynamics in healthy subjects

1984 • 222 citations

Acceleration of the ventricular response during atrial fibrillation in the Wolff-Parkinson-White syndrome after verapamil.

1982 • 212 citations

Treatment of hypertrophic obstructive cardiomyopathy with verapamil.

1979 • 207 citations

Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.

1977 • 203 citations

Influence of severity of ventricular dysfunction on hemodynamic responses to intravenously administered verapamil in ischemic heart disease

1981 • 198 citations

Verapamil in the treatment of paroxysmal supraventricular tachycardia

1974 • 195 citations

FINE STRUCTURAL CHANGES IN MYOCARDIAL ISCHEMIC INJURY.

1965 • 191 citations

Nimodipine: a new calcium antagonistic drug with a preferential cerebrovascular action

1982 • 189 citations

Effects of verapamil on myocardial performance in coronary disease.

1979 • 182 citations

Treatment of premature labor with the calcium antagonist nifedipine

1980 • 182 citations

A protective effect of verapamil on hypoxic heart muscle

1976 • 175 citations

CONTROLLED TRIAL OF NIFEDIPINE IN THE TREATMENT OF RAYNAUD'S PHENOMENON

1982 • 174 citations

Calcium-Antagonist Drugs

1985 • 172 citations

Effect of procainamide, propranolol and verapamil on mechanism of tachycardia in patients with chronic recurrent ventricular tachycardia

1977 • 170 citations

Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris

1981 • 169 citations

Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders

1984 • 168 citations

Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.

1980 • 163 citations

A randomized study comparing propranolol and diltiazem in the treatment of unstable angina

1985 • 160 citations

The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study.

1983 • 159 citations

Interaction between digoxin and calcium antagonists and antiarrhythmic drugs

1983 • 157 citations

Calcium antagonists in exercise-induced asthma.

1981 • 156 citations

Nifedipine and conventional therapy for unstable angina pectoris: a randomized, double-blind comparison.

1984 • 155 citations

Electrophysiologic and hemodynamic effects of verapamin. Correlation with plasma drug concentrations.

1978 • 150 citations

Nifedipine and propranolol: A beneficial drug interaction

1981 • 149 citations

Acute and chronic effects of nifedipine in arterial hypertension

1978 • 149 citations

Efficacy of diltiazem for control of symptoms of coronary arterial spasm

1980 • 143 citations

The effects of calcium channel blocking agents on cardiovascular function

1982 • 142 citations

Acute hemodynamic responses to sublingual nifedipine: dependence on left ventricular function.

1982 • 141 citations

Hemodynamic effects of nifedipine in congestive heart failure

1980 • 140 citations

Pathogenetic mechanisms of angina pectoris: expanding views.

1980 • 140 citations

Pharmacokinetic and pharmacodynamic effects of diltiazem

1983 • 140 citations

The Pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral doses

1982 • 140 citations

Clinical Effectiveness of Calcium Entry Blockers in Prophylactic Treatment of Migraine and Cluster Headaches

1983 • 133 citations

Calmodulin: an overview.

1982 • 133 citations

Effect of diltiazem in patients with variant angina: A randomized double-blind trial

1981 • 133 citations

Interim report of multicenter double-blind, placebo-controlled studies of nifedipine in chronic stable angina

1981 • 132 citations

Combined therapy with verapamil and propranolol in chronic stable angina

1982 • 132 citations

Comparative clinical electrophysiologic effects of diltiazem, verapamil and nifedipine: A review

1983 • 132 citations

The treatment of hypertension with verapamil.

1978 • 130 citations

Altered Calcium Handling as a Cause of Primary Hypertension

1984 • 129 citations

Vasodilator Therapy for Primary Pulmonary Hypertension

1985 • 129 citations

Verapamil Prophylaxis of Migraine

1983 • 129 citations

Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.

1979 • 126 citations

Efficacy of diltiazem in angina on effort: A multicenter trial

1982 • 125 citations

VERAPAMIL IN CHRONIC STABLE ANGINA

1980 • 124 citations

Clinical Pharmacokinetics of Verapamil

1984 • 124 citations

Pharmacology of agents that affect calcium. Agonists and antagonists.

1980 • 120 citations

Effects of ischemia on the contractile processes of heart muscle

1973 • 119 citations

Reduced verapamil clearance during long-term oral administration

1981 • 119 citations

Angina Pectoris: Pathophysiology, Evaluation, and Treatment

1971 • 119 citations

Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis.

1981 • 118 citations

Verapamil disposition kinetics in chronic atrial fibrillation

1981 • 116 citations

Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris: Report of a cooperative clinical trial

1982 • 113 citations

Provocative testing with ergonovine to assess the efficacy of treatment with nifedipine, diltiazem and verapamil in variant angina

1981 • 111 citations

Effect of Nifedipine on Oesophageal Motility and Gastric Emptying

1981 • 111 citations

Adverse Reactions to Calcium Antagonists

1983 • 108 citations

Differential effects of systemic and intracoronary calcium channel blocking agents on global and regional left ventricular function in conscious dogs

1981 • 108 citations

Pulmonary oedema precipitated by nifedipine.

1980 • 106 citations

Randomized double-blind comparison of nifedipine and isosorbide dinitrate in patients with coronary arterial spasm

1982 • 106 citations

Treatment of Primary Pulmonary Hypertension with Nifedipine

1983 • 106 citations

Oral Verapamil for Paroxysmal Supraventricular Tachycardia

1982 • 104 citations

Hemodynamics and Coronary Flow Following Diltiazem Administration in Anesthetized Dogs and in Humans

1980 • 100 citations

Some effects of iproveratril (Isoptin) on the cardiovascular system.

1968 • 100 citations

Age, race, blood pressure and renin: Predictors for antihypertensive treatment with calcium antagonists

1985 • 100 citations

Effect of nifedipine on bronchomotor tone and histamine reactivity in asthma.

1981 • 100 citations

Adverse hemodynamic and clinical effects of calcium channel blockade in pulmonary hypertension secondary to obliterative pulmonary vascular disease

1984 • 99 citations

Short- and long-term efficacy of high-dose oral diltiazem for angina due to coronary artery disease: a placebo-controlled, randomized, double-blind crossover study.

1983 • 99 citations

The Beneficial Effects of Verapamil in Chronic Atrial Fibrillation

1979 • 98 citations

Beneficial hemodynamic effects of intravenous and oral diltiazem in severe congestive heart failure

1984 • 95 citations

Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy.

1980 • 91 citations

Ionic basis of electrical activity in cardiac tissues

1978 • 91 citations

Improved exercise tolerance after propranolol, diltiazem or nifedipine in angina pectoris: Comparison at 1, 3 and 8 hours and correlation with plasma drug concentration

1984 • 89 citations

Primary pulmonary hypertension: Beneficial therapy with diltiazem

1981 • 89 citations

Electrophysiologic and hemodynamic effects of slow-channel blocking drugs

1982 • 89 citations

Randomized double-blind comparison of nifedipine and isosorbide dinitrate therapy in variant angina pectoris due to coronary artery spasm

1982 • 89 citations

Verapamil protein binding in patients and in normal subjects

1981 • 88 citations

Pharmacokinetics of diltiazem in selected animal species and human beings

1982 • 87 citations

Verapamil disposition in liver disease and intensive-care patients: Kinetics, clearance, and apparent blood flow relationships

1981 • 87 citations

Effects of Calcium-Antagonistic Coronary Vasodilators on Myocardial Contractility and Membrane Potentials

1977 • 86 citations

Effects of Nifedipine on Ventilation/Perfusion Matching in Primary Pulmonary Hypertension

1983 • 86 citations

Verapamil versus placebo in relieving stable angina pectoris.

1982 • 86 citations

Verapamil and Pulmonary Hypertension

1978 • 84 citations

Double-blind, randomized, placebo-controlled comparison of propranolol and verapamil in the treatment of patients with stable angina pectoris

1981 • 84 citations

Role of the slow current in cardiac electrophysiology.

1975 • 84 citations

Verapamil in the Treatment of Hypertension

1981 • 81 citations

Blood flow in normal and acutely ischemic myocardium after verapamil, diltiazem and nisoldipine (Bay k 5552), a new dihydropyridine calcium antagonist.

1981 • 80 citations

Comparative electrophysiologic and coronary hemodynamic effects of diltiazem, nisoldipine and verapamil on myocardial tissue

1982 • 77 citations

Cerebral Vasospasm After Subarachnoid Hemorrhage

1984 • 77 citations

Klinisch-experimentelle Untersuchungen über die blutdrucksenkende Wirkung von Verapamil

1970 • 76 citations

Randomized double-blind comparison of verapamil and nifedipine in chronic stable angina

1982 • 76 citations

Effect of verapamil on normal sinoatrial node function and on sick sinus syndrome

1978 • 75 citations

A Study of the Mechanisms Involved in the Pulmonary Arterial Pressor Response to Hypoxia

1967 • 75 citations

Clinical relevance of verapamil plasma levels in stable angina pectoris

1982 • 74 citations

Verapamil versus propranolol for angina at rest

1982 • 73 citations

The effects of intravenous verapamil on hemodynamic status of patients with coronary artery disease receiving propranolol.

1982 • 70 citations

Pharmacokinetics of verapamil in man.

1979 • 70 citations

The pharmacokinetics of diltiazem in healthy American men

1982 • 70 citations

Acute hemodynamic effect of oral nifedipine in severe chronic congestive heart failure

1983 • 69 citations

EFFECTS OF NIFEDIPINE ON MYOMETRIAL ACTIVITY AND LOWER ABDOMINAL PAIN IN WOMEN WITH PRIMARY DYSMENORRHOEA

1978 • 69 citations

Cerebral Blood Flow in Migraine

1977 • 68 citations

Increased exercise tolerance and reduced electrocardiographic ischemia with diltiazem in patients with stable angina pectoris.

1982 • 68 citations

Objective evaluation of three dose levels of diltiazem in patients with chronic stable angina

1983 • 68 citations

Nifedipine in chronic stable angina: A double-blind placebo-controlled crossover trial

1983 • 67 citations

Recent advances in studies on cardiac structure and metabolism

1973 • 66 citations

Comparative Mechanisms for Contraction of Cardiac and Skeletal Muscle

1980 • 65 citations

Superiority of verapamil to propranolol in stable angina pectoris: a double-blind, randomized crossover trail.

1982 • 64 citations

Nifedipine: Influence of renal function on pharmacokinetic/hemodynamic relationship

1985 • 63 citations

Bepridil for chronic stable angina pectoris: Results of a prospective multicenter, placebo-controlled, dose-ranging study in 77 patients

1984 • 62 citations

Hemodynamic and myocardial performance characteristics after verapamil use in congestive heart failure

1983 • 62 citations

Clinical outcome after treatment of rest angina with calcium blockers: Comparative experience during the initial year of therapy with diltiazem, nifedipine, and verapamil

1983 • 61 citations

Clinical pharmacology of slow channel blocking agents

1982 • 61 citations

Verapamil in stable effort angina: Effects on left ventricular function evaluated with exercise radionuclide ventriculography

1982 • 59 citations

Responses of Coronary Collateral Flow and Dependent Myocardial Mechanical Function to the Calcium Antagonist, Diltiazem

1980 • 57 citations

Efficacy and safety of incremental doses of diltiazem for the treatment of stable angina pectoris

1983 • 57 citations

Effects of diltiazem-induced calcium blockade upon exercise capacity in effort angina due to chronic coronary artery disease

1981 • 57 citations

Effect of verapamil on regional coronary and myocardial perfusion during acute coronary occlusion

1980 • 57 citations

Short-term efficacy of oral verapamil in rest angina

1981 • 55 citations

The Treatment of Severe Raynaud's Phenomenon with Verapamil

1982 • 55 citations

Nifedipine in the Treatment of Achalasia

1982 • 52 citations

Hemodynamic Effects of Nifedipine at Rest and during Exercise in Primary Pulmonary Hypertension

1984 • 52 citations

Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipine.

1981 • 51 citations

Antihypertensive effect of fractionated sublingual administration of nifedipine in moderate essential hypertension

1980 • 51 citations

Electrophysiologic Effects of Diltiazem, a Calcium Antagonist, in Patients With Impaired Sinus or Atrioventricular Node Function

1980 • 49 citations

Verapamil therapy for Prinzmetal's variant angina: Comparison with placebo and nifedipine

1982 • 48 citations

Multiclinic controlled trial of diltiazem for Prinzmetal's angina

1982 • 48 citations

Biochemical Basis for Contraction of Vascular Smooth Muscle

1980 • 46 citations

A double-blind controlled trial of the anti-anginal efficacy of nifedipine compared with propranolol.

1980 • 46 citations

Pharmacology of Agents that Affect Calcium

1980 • 46 citations

Efficacy and safety of sustained-release diltiazem in stable angina pectoris

1986 • 45 citations

Short- and long-term efficacy of high-dose oral diltiazem for angina due to coronary artery disease: a placebo-controlled, randomized, double-blind crossover study.

1983 • 45 citations

Hemodynamic and clinical effects of combined verapamil and propranolol therapy in angina pectoris

1982 • 44 citations

Detrimental effects of verapamil in patients with primary pulmonary hypertension.

1984 • 44 citations

Calcium-entry blockade, beta-adrenergic blockade and the reflex control of circulation.

1982 • 43 citations

Improved efficacy of high-dose versus medium- and lowdose diltiazem therapy for chronic stable angina pectoris

1984 • 42 citations

Calcium and Calcium Antagonists in Airway Disease

1984 • 42 citations

Effect of calcium antagonists on allergen‐induced asthma

1982 • 42 citations

A double-blind randomized trial of propranolol and verapamil in the treatment of effort angina.

1982 • 40 citations

Concept of Anti-Benin System Therapy

1984 • 39 citations

Treatment of severe hypertension and hypertensive emergency with nifedipine, a calcium antagonistic agent.

1981 • 39 citations

Responses of Coronary Collateral Flow and Dependent Myocardial Mechanical Function to the Calcium Antagonist, Diltiazem

1980 • 38 citations

A double‐blind controlled trial of the anti‐anginal efficacy of Nifedipine compared with Propranolol

1979 • 37 citations

Comparative effects of diltiazem, propranolol, and placebo on exercise performance using radionuclide ventriculography in patients with symptomatic coronary artery disease: Results of a double-blind, randomized, crossover study

1984 • 36 citations

Clinical and Hemodynamic Effects During Treatment of Vascular Headaches with Verapamil

1984 • 32 citations

Efficacy of nifedipine in the treatment of angina pectoris and chronic airways obstruction

1980 • 31 citations

The additive antianginal action of oral nifedipine in patients receiving propranolol: magnitude and duration of effect.

1982 • 31 citations

Calcium Channel Blockers in the Prophylactic Treatment of Vascular Headache

1985 • 31 citations

Effect of a Calcium Inhibitor, Nifedipine, on Exercise Tolerance in Patients With Angina Pectoris

1981 • 30 citations

Primary pulmonary hypertension improved by long-term oral administration of nifedipine

1983 • 30 citations

Hemodynamics and Coronary Flow Following Diltiazem Administration in Anesthetized Dogs and in Humans

1980 • 27 citations

Slow channel calcium antagonists in the treatment of supraventricular tachycardia

1982 • 27 citations

Clinical study on the hypotensive effect of diltiazem hydrochloride.

1981 • 27 citations

Management of severe hypertension with nifedipine in combination with clonidine or propranolol.

1980 • 25 citations

Rapid Attenuation of Response to Nifedipine in Primary Pulmonary Hypertension

1982 • 23 citations

A new rationale for the clinical approach to the patient with angina pectoris

1981 • 23 citations

Differential effects of calcium entry blockers on vascular smooth muscle

1984 • 22 citations

The symptomatic and objective effects of nifedipine in combination with beta-blocker therapy in severe angina pectoris

1982 • 22 citations

Investigations on the Metabolism and Protein Binding of Nifedipine

1975 • 20 citations

Efficacy of sustained-release verapamil in chronic stable angina pectoris

1987 • 19 citations

Verapamil Therapy: A New Approach to Pharmacologic Treatment of Hypertrophic Cardiomyopathy

1980 • 18 citations

Combination therapy with diltiazem and propranolol: Precipitation of congestive heart failure

1985 • 17 citations

Effects of diltiazem on conduction of premature impulses during acute myocardial ischemia and reperfusion

1981 • 16 citations

Comparison of antianginal efficacy of nifedipine and isosorbide dinitrate in chronic stable angina: A long-term, randomized, double-blind, crossover study

1985 • 16 citations

Comparison of antianginal actions of verapamil and propranolol.

1981 • 15 citations

Diuretics versus calcium-channel blockers in systemic hypertension: A preliminary multicenter experience with hydrochlorothiazide and sustained-release diltiazem

1985 • 14 citations

Effect of verapamil on conduction delay produced by myocardial ischemia and reperfusion

1981 • 12 citations

Calcium channel blockers that prolong the QT interval

1985 • 12 citations

Acute Effects of Chewable Nifedipine on Hemodynamic Responses to Upright Exercise in Patients with Prior Myocardial Infarction and Effort Angina

1983 • 11 citations

Randomized, placebo-controlled evaluation of lidoflazine in patients receiving beta-blocker therapy with propranolol: Improvement in anginal symptoms and exercise tolerance with combined drug therapy

1984 • 11 citations

Pharmacology of Nifedipine

1975 • 11 citations

The use of nifedipine as a third-step agent in the treatment of refractory hypertension.

1982 • 9 citations

Effects of nifedipine on conduction delay during ventricular myocardial ischemia and reperfusion

1981 • 9 citations

Serial hemodynamic observations in hereditary cardiomyopathy of the Syrian hamster.

1973 • 8 citations

Long-term responses to nifedipine in patients with coronary spasm who have an initial favorable response

1983 • 8 citations

Suppression of Ischemic Related Ventricular Tachycardia by Verapamil during Treadmill Exercise Testing

1982 • 5 citations

[Treatment of stable exercise angina with calcium blockers-a double-blind, placebo-controlled comparison of diltiazem and nifedipine].

1982 • 5 citations