Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

A Micro Biuret Method for Protein Determination Determination of Total Protein in Cerebrospinal Fluid

1953 • 1,089 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme

1969 • 898 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 519 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.

1976 • 350 citations

Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by Insulin

1972 • 243 citations

A partial view of the mechanism of insulin action

1981 • 215 citations

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1975 • 202 citations

The Regulation of Gluconeogenesis in Isolated Rat Liver Cells by Glucagon, Insulin, Dibutyryl Cyclic Adenosine Monophosphate, and Fatty Acids

1972 • 180 citations

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

1980 • 174 citations

The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.

1979 • 171 citations

Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats☆

1974 • 163 citations

Bimodal regulation of adenylate cyclase

1982 • 161 citations

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it

1976 • 158 citations

Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.

1982 • 151 citations

Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

1980 • 149 citations

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.

1982 • 142 citations

Phosphorylation of the hepatic insulin receptor

1982 • 126 citations

Mechanism of action of choleragen

1978 • 113 citations

Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormones

1972 • 109 citations

Studies on alpha-adrenergic activation of hepatic glucose output. Insulin inhibition of alpha-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes.

1979 • 109 citations

Changes in the form of Arrhenius plots of the activity of glucagon-stimulated adenylate cyclase and other hamster liver plasma-membrane enzymes occurring on hibernation

1978 • 106 citations

CHOLERA TOXIN

1977 • 98 citations

Hormones and Cell Regulation

1982 • 81 citations

Inhibition of adenylate cyclase by hormones and neurotransmitters.

1981 • 73 citations

Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

1981 • 61 citations

Guanosine 5′-triphosphate and guanosine 5′-[βγ-imido]triphosphate effect a collision coupling mechanism between the glucagon receptor and catalytic unit of adenylate cyclase

1980 • 57 citations

Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme.

1979 • 57 citations

Liver membrane adenylate cyclase. Synergistic effects of anions on fluoride, glucagon, and guanyl nucleotide stimulation

1975 • 56 citations

Differential effects of tryptophan on glucose synthesis in rats and guinea pigs

1978 • 54 citations

Cholera toxin modifies diverse GTP-modulated regulatory proteins

1981 • 42 citations

Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes

1979 • 41 citations

Guanine nucleotides can activate the insulin‐stimulated phosphodiesterase in liver plasma membranes

1983 • 40 citations

Solubilization and conversion of hepatic adenylate cyclase to a form requiring MnATP as substrate

1979 • 34 citations

Cell signalling: Dual control of adenylate cyclase

1983 • 32 citations

Effects of insulin on the adenylyl cyclase activity of isolated fat cell membranes

1978 • 28 citations

Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects

1983 • 24 citations

Inhibition of the glucagon stimulated adenylate cyclase activity by insulin

1978 • 18 citations

The interaction of Mn2+ with turkey erythrocyte adenylate cyclase

1982 • 11 citations