Transgenic mice expressing recombinant human protein C exhibit defects in lactation and impaired mammary gland development.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation

1995 • 285 citations

Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells

2000 • 212 citations

Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.

1991 • 143 citations

Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model

1989 • 133 citations

Regulation and functions of the protein C anticoagulant pathway.

1999 • 92 citations

[26] Protein C

1981 • 67 citations

Treatment of Coumarin-Induced Skin Necrosis With a Monoclonal Antibody Purified Protein C Concentrate

1993 • 66 citations

Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin.

1995 • 60 citations

The Effect of Mammary Gland Expression of Human Lysozyme on the Properties of Milk from Transgenic Mice

1995 • 55 citations

Protein S is a cofactor for activated protein C neutralization of an inhibitor of plasminogen activation released from platelets

1987 • 51 citations

Secretory proteins compete for production in the mammary gland of transgenic mice

1995 • 49 citations

Inefficient processing of human protein C in the mouse mammary gland

1994 • 45 citations

Regulation of human protein C gene expression by the mouse WAP promoter

1994 • 33 citations

Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels.

2001 • 28 citations

Protein C in the treatment of coagulopathy in meningococcal disease

1996 • 28 citations

Accurate spatial and temporal transgene expression driven by a 3.8-kilobase promoter of the bovine β-casein gene in the lactating mouse mammary gland

1998 • 24 citations

Proteolytic Processing of Human Protein C in Swine Mammary Gland

1995 • 24 citations

Germ line transmission in transgenic mice.

1982 • 22 citations

Rate Limitations in Posttranslational Processing by the Mammary Gland of Transgenic Animalsa

1996 • 18 citations

Protein C may be sepsis solution

2000 • 14 citations

The Expression of Therapeutic Proteins in Transgenic Animals

1991 • 12 citations