Clinical Pharmacokinetics and Pharmacodynamics of Warfarin

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

Some suggestions for measuring predictive performance

1981 • 1,576 citations

Understanding the Dose-Effect Relationship

1981 • 1,111 citations

Different Intensities of Oral Anticoagulant Therapy in the Treatment of Proximal-Vein Thrombosis

1982 • 753 citations

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

1978 • 385 citations

Calibration of Reference Thromboplastins and Standardisation of the Prothrombin Time Ratio

1983 • 301 citations

Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods

1982 • 290 citations

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

1974 • 287 citations

Drug Interactions with Coumarin Anticoagulants

1971 • 277 citations

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

1974 • 265 citations

Age as a determinant of sensitivity to warfarin.

1977 • 263 citations

Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin

1969 • 230 citations

Carboxylated Calcium-Binding Proteins and Vitamin K

1980 • 230 citations

STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: THE PHARMACODYNAMICS OF WARFARIN IN MAN*

1963 • 209 citations

Determinants of the response to oral anticoagulant drugs in man.

1970 • 193 citations

THE HEMORRHAGIC DISEASES

1958 • 191 citations

Studies on Coumarin Anticoagulant Drugs

1968 • 190 citations

Drug Interactions with Coumarin Anticoagulants

1971 • 178 citations

The NONMEM System

1980 • 174 citations

Evidence that warfarin anticoagulant action involves two distinct reductase activities.

1982 • 168 citations

Flexible induction dose regimen for warfarin and prediction of maintenance dose.

1984 • 165 citations

Extended least squares nonlinear regression: A possible solution to the “choice of weights” problem in analysis of individual pharmacokinetic data

1984 • 157 citations

Warfarin

1984 • 144 citations

R- and S-Warfarin inhibition of vitamin K and vitamin K 2,3-epoxide reductase activities in the rat.

1982 • 138 citations

Clinical Pharmacokinetics of Oral Anticoagulants

1979 • 131 citations

International Committee for Standardization in Haematology/International Committee on Thrombosis and Haemostasis: ICSH/ICTH recommendations for reporting prothrombin time in oral anticoagulant control.

1984 • 115 citations

Phenylbutazone‐warfarin interaction in man: further stereochemical and metabolic considerations.

1983 • 110 citations

Warfarin Therapy

1970 • 110 citations

Factors affecting warfarin requirements

1979 • 91 citations

Reliability and Clinical Impact of the Normalization of the Prothrombin Times in Oral Anticoagulant Control

1985 • 90 citations

Plasma disposition of vitamin K1 in relation to anticoagulant poisoning.

1984 • 86 citations

Computer-aided long-term anticoagulation therapy

1969 • 86 citations

Stereoselective Interaction of Phenylbutazone with [12C/13C]Warfarin Pseudoracemates in Man

1980 • 83 citations

ICSH/ICTH Recommendations for Reporting Prothrombin Time in Oral Anticoagulant Control

1984 • 82 citations

Pharmacokinetics and pharmacodynamics of warfarin at steady state.

1979 • 71 citations

Pharmacokinetics of warfarin enantiomers: A search for intrasubject correlations

1978 • 69 citations

Kinetics of warfarin absorption in man

1973 • 61 citations

Blood Clotting and Allied Problems:

1950 • 52 citations

SYLLABUS OF LABORATORY EXAMINATIONS IN CLINICAL DIAGNOSIS

1961 • 51 citations

The warfarin‐cimetidine interaction: stereochemical considerations.

1986 • 47 citations

Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4‐hydroxycoumarins.

1986 • 45 citations

Kinetics of R and S warfarin enantiomers

1980 • 44 citations

PREDICTING PATIENTS' WARFARIN REQUIREMENTS

1977 • 44 citations

Effects of clofibrate and warfarin alone and in combination on the disposition of vitamin K1.

1979 • 42 citations

Interindividual Differences in the Response to Oral Anticoagulants

1977 • 42 citations

Lack of interaction between ibuprofen and warfarin.

1975 • 41 citations

Effect of naproxen on the steady‐state serum concentration and anticoagulant activity of warfarin

1979 • 41 citations

A computer program for long term anticoagulation control

1977 • 40 citations

Clofibrate displaces warfarin from plasma proteins in man: an example of a pure displacement interaction.

1979 • 37 citations

Bayesian Pharmacokinetic/Pharmacodynamic Forecasting of Prothrombin Response to Warfarin Therapy

1985 • 37 citations

The cardia in swallowing, eructation, and vomiting.

1966 • 36 citations

The influence of age on the response to anticoagulants.

1977 • 36 citations

Evaluation of a computer-assisted method for individualized anticoagulation: Retrospective and prospective studies with a pharmacodynamic model

1982 • 36 citations

Multiple-dose Kinetics of Oral Anticoagulants: Methods of Analysis and Optimized Dosing

1973 • 35 citations

Intensive Initial Oral Anticoagulation and Shorter Heparin Treatment in Deep Vein Thrombosis

1984 • 32 citations

Pharmacokinetics of warfarin in the nephrotic syndrome and effect on vitamin K-dependent clotting factors.

1986 • 31 citations

Pharmacokinetics of warfarin following intravenous administration to man.

1971 • 30 citations

Lack of interaction between ibuprofen and warfarin.

1975 • 29 citations

Effect of naproxen on the kinetics of elimination and anticoagulant activity of a single dose of warfarin

1979 • 28 citations

Antipyrine and warfarin disposition in a patient with idiopathic hypoalbuminemia

1981 • 27 citations

Monitoring effects of oral anticoagulants during treatment with heparin.

1984 • 22 citations

Plasma Protein Binding of Warfarin: Methodological Considerations

1984 • 22 citations

A simple technic for predicting daily maintenance dose of warfarin

1979 • 21 citations

WARFARIN SODIUM: STEADY‐STATE PLASMA LEVELS AND PATIENT AGE

1978 • 21 citations

Intrasubject variation of warfarin binding to protein in serum of patients with cardiovascular disease

1976 • 20 citations

Warfarin Dosage following Prosthetic Valve Replacement: Effect of Smoking History

1984 • 18 citations

Systems and Microcomputer Approach to Anticoagulant Therapy

1980 • 18 citations

Predicting warfarin maintenance dosage based on initial response

1979 • 17 citations

Comparison of the bioavailabilities and anticoagulant activities of two warfarin formulations

1982 • 17 citations

Predicting the Dose of Warfarin for Therapeutic Anticoagulation

1982 • 14 citations

RELATIONSHIP OF AGE, WEIGHT AND BODY SURFACE AREA TO WARFARIN MAINTENANCE DOSE REQUIREMENTS

2008 • 11 citations

Predictability of Warfarin Dose Requirements: Theoretical Considerations

1979 • 10 citations

Prediction of Maintenance Warfarin Dosage from Initial Patient Response

1983 • 9 citations

Warfarin sensitivity in the elderly

1979 • 9 citations

Digital computer-assisted warfarin therapy: Comparison of two models

1979 • 8 citations

Relationships between Steady-State Warfarin Concentrations and Anticoagulant Effect

1984 • 8 citations

Effect of heparin on prothrombin time.

1984 • 8 citations

PREDICTING WARFARIN DOSAGE

1983 • 4 citations

Pleural Effusions in Nonbacterial Pneumonias

1970 • 4 citations

Predictability of the warfarin maintenance dosage based on the initial response.

1981 • 4 citations

Warfarin maintenance-dose prediction based upon initial anticoagulant response

1984 • 4 citations

No-Load Warfarin Therapy

1970 • 3 citations

USE OF A WARFARIN DOSE PREDICTION METHOD

1984 • 2 citations

The optimal duration of initial heparin treatment for venous thromboembolism

1984 • 1 citations

Deleted Work

1955 • 0 citations