Understanding the Dose-Effect Relationship

The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves

1910 • 2,184 citations

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine

1979 • 1,136 citations

Fundamentals of Clinical Pharmacokinetics

1975 • 1,035 citations

DESIGN OF EXPERIMENTS IN NON-LINEAR SITUATIONS

1959 • 692 citations

Rational Intravenous Doses of Theophylline

1973 • 666 citations

Digitalis Intoxication

1971 • 579 citations

Pharmacology and Therapeutics.

1886 • 552 citations

Kinetics of pharmacologic response

1982 • 508 citations

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

1978 • 385 citations

Drill's Pharmacology in Medicine.

1972 • 303 citations

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

1968 • 303 citations

Daily and Alternate-Day Corticosteroid Regimens in Treatment of Giant Cell Arteritis

1975 • 297 citations

Protein Binding of Diphenylhydantoin and Desmethylimipramine in Plasma from Patients with Poor Renal Function

1971 • 296 citations

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

1974 • 287 citations

D-Optimality for Regression Designs: A Review

1975 • 279 citations

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

1974 • 265 citations

Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin

1969 • 230 citations

Studies on the optical enantiomorphs of warfarin in man

1974 • 215 citations

Oral Cocaine: Plasma Concentrations and Central Effects

1978 • 206 citations

Pharmacological evaluation of cimetidine, a new histamine H2‐receptor antagonist, in healthy man.

1975 • 198 citations

General Treatment of Linear Mammillary Models with Elimination from any Compartment as Used in Pharmacokinetics

1972 • 198 citations

A PHARMACODYNAMIC MODEL FOR PANCURONIUM

1978 • 197 citations

Hypersensitivity to Adrenergic Stimulation after Propranolol Withdrawal in Normal Subjects

1977 • 186 citations

A molecular basis for drug action

1964 • 175 citations

Relationship between the pharmacokinetics and pharmacodynamics of procainamide

1976 • 155 citations

Pharmacokinetic and pharmacodynamic modeling in vivo.

1981 • 148 citations

Clinical efficacy and pharmacokinetics of a new orally effective antiarrhythmic, tocainide.

1976 • 140 citations

Antiarrhythmic potency of N‐acetylprocainamide

1975 • 133 citations

The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration‐effect relationships.

1981 • 126 citations

Relationship of Plasma Digitoxin and Digoxin to Cardiac Response Following Intravenous Digitalization in Man

1970 • 102 citations

Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs

1978 • 101 citations

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1980 • 97 citations

Optimized blood sampling protocols and sequential design of kinetic experiments

1981 • 89 citations

Computer-aided long-term anticoagulation therapy

1969 • 86 citations

Stereoselective Interaction of Phenylbutazone with [12C/13C]Warfarin Pseudoracemates in Man

1980 • 83 citations

Pharmacokinetics and Bioavailability of Cimetidine in Gastric and Duodenal Ulcer Patients

1980 • 82 citations

Quantitative analysis of the disopyramide concentration‐effect relationship.

1980 • 76 citations

Pharmacokinetics and pharmacodynamics of warfarin at steady state.

1979 • 71 citations

Receptors, Neurotransmitters and Drug Responses

1979 • 70 citations

Comparative Pharmacokinetics of Coumarin Anticoagulants I

1968 • 69 citations

Pathophysiologic and pharmacokinetic determinants of the antihypertensive response to propranolol

1977 • 67 citations

The relation of arterial pressure and plasma angiotensin II concentration. A change produced by prolonged infusion of angiotensin II in the conscious dog.

1979 • 66 citations

The Onset and Magnitude of the Contractile Response to Commonly Used Digitalis Glycosides in Normal Subjects

1974 • 64 citations

Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects

1968 • 64 citations

Pharmacokinetics of digoxin: Relationship between response intensity and predicted compartmental drug levels in man

1979 • 64 citations

A molecular basis for drug action.: The interaction of one or more drugs with different receptors

1964 • 64 citations

Model-Independent Method of Analyzing Input in Linear Pharmacokinetic Systems Having Polyexponential Impulse Response I: Theoretical Analysis

1980 • 63 citations

Quinidine pharmacokinetics in man: Choice of a disposition model and absolute bioavailability studies

1979 • 63 citations

Response optimization of drug dosage: Antiarrhythmie studies with tocainide

1977 • 54 citations

Relationship between concentration and anticoagulant effect of heparin in plasma of normal subjects: Magnitude and predictability of interindividual differences*

1980 • 49 citations

Reduction of digoxin-induced inotropism during quinidine administration

1980 • 48 citations

Modeling of drug response in individual subjects

1980 • 47 citations

Long‐term antiarrhythmic therapy with N‐acetylprocainamide

1979 • 43 citations

Comparison of the intrarenal disposition of tobramycin and gentamicin: therapeutic and toxicologic answers

1978 • 41 citations

RELATIONSHIP BETWEEN RATE OF ELIMINATION OF TUBOCURARINE AND RATE OF DECLINE OF ITS PHARMACOLOGICAL ACTIVITY

1964 • 36 citations

The effect of dosage regimen on the diuretic efficacy of chlorothiazide in human subjects.

1961 • 27 citations

Derivation of general equations for linear mammillary models when the drug is administered by different routes

1975 • 24 citations

Plasma levels and effects of metoprolol after single and multiple oral doses

1980 • 22 citations

Plasma timolol levels and systolic time intervals

1980 • 18 citations

Systems and Microcomputer Approach to Anticoagulant Therapy

1980 • 18 citations

The interaction of morphine and d‐tubocurarine on respiration and grip strength in man

1964 • 15 citations

Tiotidine and cimetidine—kinetics and dynamics

1981 • 14 citations

Digital plethysmography for assessing erythrityl tetranitrate bioavailability

1981 • 13 citations

Comparative Pharmacokinetics of Coumarin Anticoagulants XLV: Pharmacokinetic and Pharmacodynamic Studies of Acute Interaction between Warfarin and Phenylbutazone in Rats

1980 • 13 citations

Kinetics of pharmacologic response to cocaine.

1978 • 12 citations

Significance of the acetylation phenotype and the therapeutic effect of procainamide

1979 • 12 citations

Warfarin sensitivity in the elderly

1979 • 9 citations

Apparent enhanced stability in acid media of the ethyleniminium ion derived from dibenamine

1975 • 1 citations