The Neuropharmacology of Ethanol Self-Administration

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

Neuropsychopharmacology

1990 • 1,545 citations

Research Advances in Alcohol and Drug Problems

1984 • 1,126 citations

Recent Developments in Alcoholism

1987 • 1,046 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

1986 • 852 citations

Catecholamine theories of reward: A critical review

1978 • 766 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

Production of Polydipsia in Normal Rats by an Intermittent Food Schedule

1961 • 720 citations

Initiation of Ethanol Reinforcement using a Sucrose‐Substitution Procedure in Food‐ and Water‐Sated Rats

1986 • 668 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

Increased Lever Pressing for Amphetamine After Pimozide in Rats: Implications for a Dopamine Theory of Reward

1975 • 536 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

1983 • 491 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Alcohol Intoxication and Withdrawal

1976 • 481 citations

Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration

1979 • 460 citations

The neuropharmacological basis of reward

1991 • 457 citations

Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats

1982 • 451 citations

Alcohol tolerance and dependence

1980 • 419 citations

Alteration of ethanol self-administration by naltrexone

1980 • 402 citations

Voluntary ethanol intake in rats following exposure to ethanol on various schedules

1973 • 383 citations

Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats

1976 • 371 citations

Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man

1973 • 369 citations

Biochemistry and Pharmacology of Ethanol

1979 • 353 citations

Action of drugs of abuse on brain reward systems

1980 • 330 citations

Drugs and Reinforcement Mechanisms: A Critical Review of the Catecholamine Theory

1978 • 293 citations

Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats

1987 • 289 citations

Suppression of deprivation-induced food and water intake in rats and mice by naloxone

1979 • 282 citations

Bioenergetics Bulletin Prospers

1970 • 281 citations

Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the Rat

1972 • 268 citations

Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary

1980 • 267 citations

Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats

1982 • 264 citations

Biological Effects of Alcohol

1980 • 254 citations

The neuropharmacological basis of reward

1991 • 249 citations

Criteria for an animal model of alcoholism

1973 • 238 citations

Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide

1990 • 237 citations

Neural Mechanisms of the Reinforcing Action of Cocaine

1984 • 220 citations

Increased preference for ethanol in rats following alcohol deprivation

1967 • 213 citations

A review of methods to induce alcohol addiction in animals

1973 • 210 citations

Morphine and naloxone modulate intake of ethanol

1984 • 209 citations

Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring lines of rats

1986 • 209 citations

Alcohol Taste Thresholds and Concentrations of Solution Preferred by Rats

1940 • 203 citations

Effects of ethanol on neurotransmitter release by rat brain cortical.

1975 • 199 citations

Action of drugs of abuse on brain reward systems: An update with specific attention to opiates

1982 • 194 citations

The suppressant effects of naloxone on food and water intake in the rat

1979 • 193 citations

Naltrexone blocks the post-shock increase of ethanol consumption

1986 • 193 citations

Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats

1989 • 183 citations

Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats

1982 • 172 citations

Oral ethanol self-administration in the rat: Effect of naloxone

1985 • 168 citations

Central Deficiency of β-Endorphin in Alcohol Addicts*

1982 • 168 citations

Response Artifact in the Measurement of Neuroleptic-Induced Anhedonia

1981 • 165 citations

Suppression of appetitive behavior in the rat by naloxone: Lack of effect of prior morphine dependence

1979 • 164 citations

Effect of spontaneous ingestion of ethanol on brain dopamine metabolism

1989 • 163 citations

Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats

1988 • 156 citations

Advances in behavioral pharmacology, Vol. 4

1985 • 152 citations

Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin

1968 • 150 citations

A Critique of Animal Analogues of Alcoholism

1979 • 149 citations

Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary

1983 • 146 citations

Naloxone: Effects on food and water consumption in the non-deprived and deprived rat

1980 • 142 citations

Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats

1988 • 140 citations

Isoquinolines, beta-carbolines and alcohol drinking: Involvement of opioid and dopaminergic mechanisms

1989 • 127 citations

Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats

1988 • 126 citations

Research Advances in Alcohol and Drug Problems

1983 • 125 citations

Research Advances in New Psychopharmacological Treatments for Alcoholism

1988 • 122 citations

Alcohol interactions with brain opiate receptors

1983 • 121 citations

Effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens.

1983 • 120 citations

Alcohol consumption in free-feeding rats: procedural, genetic and pharmacokinetic factors

1987 • 119 citations

Alcohol Aversion in the Rat: Behavioral Assessment of Noxious Drug Effects

1970 • 115 citations

A new factor affecting the consumption of ethyl alcohol and other sapid fluids

1972 • 113 citations

Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain.

1975 • 106 citations

Reduction of heroin intake in baboons by an economic constraint

1980 • 106 citations

Neurotransmitter Interactions in the Basal Ganglia

1988 • 105 citations

Ethanol Modulation of Opiate Receptors in Cultured Neural Cells

1983 • 101 citations

Ethanol Self-Administration: Infrahuman Studies

1977 • 100 citations

Zimeldine: A review of its effects on ethanol consumption

1984 • 99 citations

Advances in Biochemical Pharmacology

1994 • 96 citations

An investigation of the mechanisms of action of 5-hydroxytryptamine in the suppression of ethanol intake

1982 • 94 citations

Self-inhibitory dopamine receptors: their role in the biochemical and behavioral effects of low doses of apomorphine.

1978 • 93 citations

Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat

1973 • 93 citations

Cocaine: Clinical and Biobehavioral Aspects.

1987 • 92 citations

The effect of ethanol on the biosynthesis and regulation of opioid peptides

1989 • 90 citations

A critical evaluation of tetrahydroisoquinoline induced ethanol preference in rats

1980 • 90 citations

Naloxone alters alcohol drinking induced in the rat by tetrahydropapaveroline (THP) infused ICV

1982 • 86 citations

EFFECTS OF ETHANOL ON SEROTONIN METABOLISM IN BRAIN

1974 • 85 citations

Tetrahydroisoquinolines in the Brain: The Basis of an Animal Model of Alcoholism

1978 • 81 citations

Decrease in ethanol consumption by naloxone in naive and dependent rats

1983 • 81 citations

Neurotransmitter Interactions in the Basal Ganglia

1987 • 80 citations

INHIBITION OF THE TRANSPORT OF 5‐HYDROXYINDOLEACETIC ACID FROM BRAIN BY ETHANOL¹

1975 • 79 citations

Induction and maintenance of ethanol self-administration without food deprivation in the rat

1985 • 79 citations

Naloxone reduces fluid consumption in water-deprived and nondeprived rats

1979 • 78 citations

Cocaine: Clinical and biobehavioral aspects

1988 • 76 citations

A comparison of the discriminative stimulus effects of ethanol, barbital, and phenobarbital in rats

1978 • 75 citations

On the role of ascending dopamine systems in the control of voluntary ethanol intake and ethanol intoxication

1979 • 74 citations

Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats. I. Involvement of brain 5-hydroxytryptamine in the mediation of the positive reinforcing properties of ethanol.

1979 • 74 citations

The development of metabolic tolerance in the alcohol-preferring P rats: Comparison of forced and free-choice drinking of ethanol

1986 • 73 citations

Effect of pimozide on home cage ethanol drinking in the rat: Dependence on drinking session length

1986 • 73 citations

Drinking of Ethanol by Rhesus Monkeys: Experimental Strategies for Establishing Ethanol as a Reinforcer

1977 • 72 citations

Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone

1983 • 71 citations

The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats

1977 • 69 citations

Acute and chronic ethanol ingestion and serotonin metabolism in rat brain.

1978 • 67 citations

THE ROLE OF CEREBRAL SEROTONIN IN THE ETHANOL PREFERENCE OF ANIMALS

1973 • 65 citations

Effect of acute ethanol treatment on transmitter synthesis and metabolism in central dopaminergic neurons

1976 • 64 citations

Reexamination of the relationship between alcohol preference and brain monoamines in inbred strains of mice including senescence-accelerated mice

1987 • 64 citations

Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol Administration

1978 • 63 citations

Turnover rates and steady-state levels of brain serotonin in alcohol-dependent rats

1974 • 62 citations

A neuroanatomical substrate for alcohol drinking: Identification of tetrahydropapaveroline (THP)-reactive sites in the rat brain

1989 • 61 citations

Acute and chronic ethanol treatment on beta-endorphin and catecholamine levels

1989 • 61 citations

Experimental studies on alcoholism I. Increased in alcohol preference by 5,6-dihydroxytryptamine and brain acetylcholine

1974 • 60 citations

Actions of drugs of abuse on brain reward systems: A reconsideration with specific attention to alcohol

1982 • 60 citations

Opiate antagonists and rewarding brain stimulation

1988 • 59 citations

Pharmacological evidence for a role of brain serotonin in the maintenance of plasma renin activity in unanesthetized rats.

1981 • 59 citations

Bromocriptine produces decreases in cocaine self-administration in the rat.

1990 • 59 citations

Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats

1982 • 59 citations

Opiate receptor binding and analgesic effects of the tetrahydroisoquinolines salsolinol and tetrahydropapaveroline.

1980 • 58 citations

Naloxone reduces fluid intake: Effects of water and food deprivation

1980 • 57 citations

Ethanol intake in the absence of concurrent food reinforcement

1971 • 56 citations

A further investigation of alcohol preference in the laboratory rat induced by hypothalamic stimulation

1971 • 56 citations

Biochemical evidence for activation of specific monoanine pathways by ethanol

1988 • 55 citations

Chronic ethanol imbibition interferes with δ-, but not with μ-opiate receptors

1981 • 52 citations

Naloxone attenuation of voluntary alcohol consumption.

1987 • 51 citations

Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring C57BL mice

1982 • 50 citations

Etiologic Aspects of Alcohol and Drug Abuse

1984 • 50 citations

Opioids, benzodiazepines and intake of ethanol

1984 • 50 citations

Oral ethanol reinforcement: interactive effects of amphetamine, pimozide and food-restriction.

1985 • 49 citations

Effects of hypothalamic stimulation, acclimation and periodic withdrawal on ethanol consumption

1972 • 49 citations

Ethanol and GABA.

1983 • 47 citations

Animal models for the study of alcohol addiction

1976 • 47 citations

Effects of Serotonin Uptake Blockade on Food, Water, and Ethanol Consumption in Rats

1987 • 45 citations

Naloxone decreases ethanol consumption within a free choice paradigm in rats

1988 • 42 citations

Dopamine D₂ Receptor Binding in Striatal Membranes of Rat Lines Selected for Differences in Alcohol‐related Behaviours

1987 • 41 citations

Acetaldehyde and Its Condensation Products as Markers in Alcoholism

1988 • 41 citations

Decrease in ethanol intake in rats following administration of p-chlorophenylalanine

1970 • 41 citations

The effect of chronic ethanol administration on central neurotransmitter mechanisms.

1979 • 40 citations

Relative responding on concurrent schedules: Indexing ethanol's reinforcing efficacy

1982 • 40 citations

Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance

1981 • 40 citations

The effect of acute ethanol on dopamine metabolism and other neurotransmitters in the hypothalamus and the corpus striatum of mice

1984 • 40 citations

Pharmacological Evidence that Stimulation of Central Serotonergic Pathways Increases Renin Secretion

1980 • 40 citations

Studies of neurotransmitter interactions after acute and chronic ethanol administration

1983 • 39 citations

Isolation and striatal (3H) serotonin uptake: Role in the voluntary intake of ethanol by rats

1985 • 38 citations

A comparison of the effects of opiate antagonists on operant and ingestive behavior

1982 • 38 citations

Effects of small doses of haloperidol on timing behaviour

1971 • 37 citations

Ethanol Increases Opioid Activity in Plasma of Normal Volunteers

1981 • 37 citations

Animal Studies of Alcohol Intake

1982 • 35 citations

A simplified procedure for producing ethanol self-selection in rats

1984 • 34 citations

Naloxone, but not Tyr-MIF-1, reduces volitional ethanol drinking in rats: Correlation with degree of spontaneous preference

1988 • 34 citations

Etiologic Aspects of Alcohol and Drug Abuse

1982 • 33 citations

Ethanol and dopaminergic systems

1983 • 32 citations

Chronic Ingestion Techniques for the Production of Physical Dependence on Ethanol

1973 • 32 citations

Ethanol as a Reinforcer for Rats: Factors of Faciliation and Constraint

1988 • 32 citations

ACTIONS OF ETHANOL ON NEURONAL MEMBRANE PROPERTIES AND SYNAPTIC TRANSMISSION**Portions of this work were supported by NINCDS Grant # NS12132. The authors acknowledge the services of the Analytical Laboratory of the Research Institute on Alcoholism and thank Dr. Cedric M. Smith for his critical comments on the manuscript.

1977 • 31 citations

Rates of ethanol disappearance from blood and hypothermia following acute and prolonged ethanol inhalation

1979 • 30 citations

Drug interactions on spontaneous locomotor activity in rats

1984 • 30 citations

Alcohol Intoxication and Withdrawal

2006 • 29 citations

Alcohol intake in the rat after lowering brain 5-hydroxtryptamine content by electrolytic midbrain raphé lesions, 5, 6-dihydroxytryptamine or p-chlorophenylalanine.

1976 • 28 citations

Effects of Ethanol In Vitro and In Vivo on the Release of Endogenous Catecholamines from Specific Regions of Rat Brain

1985 • 27 citations

electrochemical determination of extracellular dopamine in the caudate of freely-moving rats after a low dose of ethanol

1987 • 27 citations

Chronic Ethanol Administration Decreases 5‐HT and Increases 5‐HIAA Concentration in Rat Brain

1980 • 27 citations

NEUROCHEMICAL ASPECTS OF ETHANOL DEPENDENCE**This work was supported by U.S. Public Health Service Grants NS-12759 and AA-2696 and a Campus Research Board Grant from the University of Illinois. B.T. is a Schweppe Foundation Fellow.

1977 • 27 citations

Effect of Modification of Brain Serotonin (5‐HT) on Ethanol Tolerance

1979 • 27 citations

Reduction in striatal 5-hydroxytryptamine turnover following chronic administration of ethanol to rats.

1987 • 26 citations

Systemic and intraventricular naloxone administration: Effects on food and water intake

1981 • 26 citations

Oral ethanol reinforcement in the rat: Effects of acute amphetamine

1985 • 26 citations

Angiotensin II-induced suppression of alcohol intake and its reversal by the angiotensin antagonist Sar-1 Thr-8 angiotensin II

1988 • 25 citations

OPPOSITE EFFECTS OF CHRONIC ADMINISTRATION AND SUBSEQUENT WITHDRAWAL OF DRUGS OF DEPENDENCE ON THE METABOLISM AND DISPOSITION OF ENDOGENOUS AND EXOGENOUS TRYPTOPHAN IN THE RAT

1983 • 24 citations

Recent Developments in Alcoholism, vol. 4

1987 • 24 citations

Effects of parachlorophenylalanine on ethanol self-selection in the rat

1976 • 22 citations

Effects of ethanol on 5-hydroxytryptamine release from rat corpus striatum in vivo

1985 • 22 citations

Ethanol selection in the rat following forced acclimation

1973 • 21 citations

Studies on an animal model of alcoholism.

1986 • 20 citations

The mode of action of bromocriptine following pretreatment with reserpine and ?-methyl-p-tyrosine in rats

1988 • 20 citations

Evaluation of ocular toxicity of two beta blocking drugs, carteolol and practolol, in beagle dogs.

1983 • 19 citations

On the effects of antirheumatic drugs on protein sulphydryl reactivity in human serum

1980 • 19 citations

NOTE ON THE RETENTION OF CONNECTED DISCOURSE

1967 • 17 citations

The effects of dietary niacin and riboflavin on voluntary intake and metabolism of ethanol in rats

1979 • 16 citations

Current Developments in Psychopharmacology, vol 4

1978 • 16 citations

Oxidative decarboxylation of salsolinol-1-carboxylic acid to 1,2-dehydrosalsolinol: Evidence for exclusive catalysis by particulate factors in rat kidney

1988 • 15 citations

Pictet-Spengler condensation products, stress and alcoholism: some clinical overtones.

1982 • 14 citations

Beobachtungen bei Alkohol trinkenden Ratten – Einfluß von Fenfluramin

1969 • 14 citations

Attraction to ethanol solutions in mice: induction by a tetrahydroisoquinoline derivative of L-DOPA.

1982 • 12 citations

The effect of para-Chlorophenylalanine on the intake of ethanol and saccharin solutions

1977 • 12 citations

Catecholaminergic Involvement in Alcohol’s Rewarding Properties: Implications for a Treatment Model for Alcoholics

1977 • 11 citations

Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates

1980 • 7 citations

Deleted Work

1955 • 0 citations