The Multiplicity of the D1 Dopamine Receptor

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Multiple receptors for dopamine

1979 • 3,739 citations

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

Isolated removal of hypothalamic or other brain nuclei of the rat

1973 • 1,421 citations

Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”

1972 • 1,022 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.

1983 • 886 citations

SCH 23390—The first selective dopamine D-1 antagonist

1983 • 738 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum

1984 • 566 citations

Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity

1976 • 564 citations

The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

1976 • 543 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 541 citations

Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines

1981 • 535 citations

Dopamine Receptors in the Brain

1975 • 528 citations

Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs

1974 • 450 citations

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

1978 • 401 citations

The Classification of Dopamine Receptors: Relationship to Radioligand Binding

1983 • 392 citations

Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics

1984 • 373 citations

Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.

1983 • 355 citations

Cyclic Nucleotides in the Nervous System

1977 • 297 citations

[47] Isolation of synaptosomal and synaptic plasma membrane fractions

1974 • 295 citations

Stimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3′:5′-Cyclic Monophosphate Formation in Intact Retina

1972 • 286 citations

Regulatory peptides from molecular biology to function.

1982 • 263 citations

Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitro

1978 • 261 citations

CNS receptors: From molecular pharmacology to behavior

1983 • 218 citations

Subcellular localization of dopamine-sensitive adenylate cyclase and dopamine receptor binding activities

1978 • 198 citations

Dopaminergic and Noradrenergic Substrates of Positive Reinforcement: Differential Effects of d - and l -Amphetamine

1973 • 197 citations

Interactions of neurotensin with brain dopamine systems: biochemical and behavioral studies.

1983 • 184 citations

Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum.

1976 • 160 citations

SCH-23390: A selective D1 dopamine antagonist with potent D2 behavioral actions

1984 • 158 citations

Effects of dopamine-like drugs on rat striatal adenyl cyclase have implications for CNS dopamine receptor topography

1974 • 151 citations

Optimal Conditions for [³H]Apomorphine Binding and Anomalous Equilibrium Binding of [³H]Apomorphine and [³H]Spiperone to Rat Striatal Membranes: Involvement of Surface Phenomena Versus Multiple Binding Sites

1981 • 130 citations

Binding of [³H]SCH23390 in Rat Brain: Regional Distribution and Effects of Assay Conditions and GTP Suggest Interactions at a D₁‐Like Dopamine Receptor

1985 • 116 citations

Effects of neurohumoral and adrenergic agents on cyclic amp levels in various areas of the rat brain in vitro

1973 • 112 citations

Graphical Methods in Enzyme Chemistry

1957 • 106 citations

Dissociation between the presynaptic dopamine-sensitive adenylate cyclase and [3H]spiperone binding sites in rat substantia nigra

1979 • 100 citations

Increase in dopamine metabolites in rat brain by neurotensin.

1982 • 99 citations

Effects of bromocriptine on central dopaminergic receptors

1976 • 98 citations

Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro

1981 • 98 citations

Effects of ergots on adenylate cyclase activity in the corpus striatum and pituitary

1977 • 97 citations

Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.

1981 • 96 citations

Role of dopamine in d-amphetamine-induced discriminative responding

1975 • 85 citations

Characteristics of dopamine and β-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases

1977 • 81 citations

Noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine

1976 • 73 citations

CNS receptors : from molecular pharmacology to behavior

1983 • 71 citations

Preferential inhibition of ligand binding to calf striatal dopamine D1 receptors by SCH 23390

1983 • 66 citations

[3H]SCH23390 has the characteristics of a dopamine receptor ligand in the rat central nervous system

1984 • 55 citations

Radioreceptor assay of haloperidol tissue levels in the rat

1980 • 51 citations

Dopamine Receptors in the Central Nervous System

1982 • 51 citations

Multiple forms of the D1 dopamine receptor: its linkage to adenylate cyclase and psychopharmacological effects.

1986 • 51 citations

The brain's dopamine receptor: labeling with (3H) dopamine and (3H) haloperidol.

1975 • 47 citations

SCH23390 effects on apomorphine-induced responses of nigral dopaminergic neurons.

1986 • 46 citations

SCH23390 causes persistent antidopaminergic effects in vivo: Evidence for longterm occupation of receptors

1985 • 40 citations

Effects of thioridazine and its metabolites on dopaminergic function: drug metabolism as a determinant of the antidopaminergic actions of thioridazine.

1984 • 40 citations

The Multiplicity of the D1 Dopamine Receptor

1986 • 38 citations

An Improved, Automated Adenylate Cyclase Assay Utilizing Preparative HPLC: Effects of Phosphodiesterase Inhibitors

1984 • 35 citations

Further characterization of structural requirements for agonists at the striatal dopamine D2 receptor and a comparison with those at the striatal dopamine D1 receptor. Studies with a series of monohydroxyaminotetralins on acetylcholine release from rat striatum.

1984 • 34 citations

Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.

1984 • 32 citations

Dopamine Receptors

1982 • 31 citations

Subcellular localization of dopamine-sensitive adenylate cyclase in rat brain striatum

1976 • 31 citations

Quantification of R-(+)-7-chloro-8-hydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-methyl-3-benzazepine in brain and blood by use of reversed-phase high-performance liquid chromatography with electrochemical detection

1985 • 30 citations

N-oxides of phenothiazine antipsychotics: effects on in vivo and in vitro estimates of dopaminergic function.

1983 • 30 citations

Effect of dopaminergic agonists and antagonists on in vivo cyclic nucleotide content: relation of guanosine 3':5'- monophosphate (cGMP) changes in cerebellum to behavior.

1979 • 28 citations

Distinction between dopaminergic and serotonergic components of neuroleptic binding sites in limbic brain areas

1979 • 28 citations

Dopaminergic 3H-agonist receptors in rat brain new evidence on localization and pharmacology

1984 • 27 citations

Metabolism, Distribution and Excretion of Flupenthixol

1969 • 27 citations

In vivo dopamine receptor binding studies with a non-radioactively labeled agonist, dipropyl-5, 6-ADTN

1983 • 25 citations

Beta adrenergic receptor-mediated adenosine cyclic 3',5'-monophosphate accumulation in the ratcorpus striatum.

1976 • 22 citations

Analytical Subcellular Fractionation of Rat Cortex: Resolution of Serotonergic Nerve Endings and Receptors

1983 • 22 citations

Greater potency of mesoridazine and sulforidazine compared with the parent compound, thioridazine, on striatal dopamine autoreceptors.

1984 • 19 citations

Clinical relevance of dopamine receptor classification

1980 • 17 citations

In vivo dopamine receptor agonist binding in rat brain: Relation with pharmacological effects

1983 • 15 citations

Ascorbic acid decreases [3H]dopamine binding in striatum without inhibiting dopamine-sensitive adenylate cyclase

1984 • 14 citations

Modification of the amphetamine-induced stereotypy in rats following inhibition of the noradrenaline release by FLA 136

1977 • 11 citations

Comparison of the inhibitory effects of neuroleptic drugs on adenylate cyclase in rat tissues stimulated by dopamine, noradrenaline and glucagon

1976 • 11 citations

DOPAMINE RECEPTORS IN BRAIN

1984 • 9 citations

S(?)DP-5,6-ADTN as an in vivo dopamine receptor ligand: Relation between displacement by dopamine agonists and their pharmacological effects

1986 • 6 citations

Effect of catecholamines on locomotor activity and cyclic AMP in nucleus accumbens in rats

1983 • 6 citations

On the mechanism of inhibition of dopamine receptors by fluphenazine

1983 • 5 citations

In vivo dopamine receptor binding of a non-radioactively labelled agonist, dipropyl-5, 6-ADTN

1983 • 5 citations

DOPAMINE RECEPTOR MULTIPLICITY - WHEN THE D1-ANTAGONIST IS A D2-ANTAGONIST

1984 • 3 citations