Minireview: RET: Normal and Abnormal Functions

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

Oncogenic kinase signalling

2001 • 3,632 citations

A census of human cancer genes

2004 • 3,190 citations

CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2

2001 • 1,852 citations

The GDNF family: Signalling, biological functions and therapeutic value

2002 • 1,722 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

The discovery of receptor tyrosine kinases: targets for cancer therapy

2004 • 1,186 citations

The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

1996 • 1,055 citations

Thyroid carcinoma

2003 • 864 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

The Relationship Between Specific RET Proto-oncogene Mutations and Disease Phenotype in Multiple Endocrine Neoplasia Type 2

1996 • 725 citations

ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

2002 • 554 citations

Early Malignant Progression of Hereditary Medullary Thyroid Cancer

2003 • 531 citations

Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human Cells

2000 • 457 citations

SH2 and PTB Domains in Tyrosine Kinase Signaling

2003 • 316 citations

The RET proto-oncogene in human cancers

2000 • 295 citations

The RET receptor: function in development and dysfunction in congenital malformation

2001 • 286 citations

Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis

2001 • 249 citations

Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors

2004 • 239 citations

RET and neuroendocrine tumors

2003 • 196 citations

Cancer after nuclear fallout: lessons from the Chernobyl accident

2002 • 151 citations

Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities

1996 • 144 citations

The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.

2002 • 133 citations

Coordinated Activation of Autophosphorylation Sites in the RET Receptor Tyrosine Kinase

2002 • 125 citations

Efficient Inhibition of RET/Papillary Thyroid Carcinoma Oncogenic Kinases by 4-Amino-5-(4-Chloro-Phenyl)-7-(t-Butyl)Pyrazolo[3,4-d]Pyrimidine (PP2)

2003 • 113 citations

Cellular Effects and Antitumor Activity of RET Inhibitor RPI-1 on MEN2A-Associated Medullary Thyroid Carcinoma

2004 • 113 citations

Preferential induction of RET/PTC1 rearrangement by X-ray irradiation

2000 • 109 citations

Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas.

2000 • 98 citations

Identification of RET Autophosphorylation Sites by Mass Spectrometry

2004 • 97 citations

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas¹

2000 • 95 citations

CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth.

2003 • 92 citations

Expression Profiles Provide Insights into Early Malignant Potential and Skeletal Abnormalities in Multiple Endocrine Neoplasia Type 2B Syndrome Tumors

2004 • 72 citations

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas

2000 • 66 citations

Tyrosines 1015 and 1062 Arein VivoAutophosphorylation Sites in Ret and Ret-Derived Oncoproteins¹

2000 • 60 citations

Amplification and Overexpression of Mutant RET in Multiple Endocrine Neoplasia Type 2-Associated Medullary Thyroid Carcinoma

2003 • 59 citations

Regulation of p27Kip1 Protein Levels Contributes to Mitogenic Effects of the RET/PTC Kinase in Thyroid Carcinoma Cells

2004 • 53 citations

Co-segregation of MEN2 and Hirschsprung's disease: The same mutation ofRET with both gain and loss-of-function?

1999 • 52 citations

PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting.

2003 • 46 citations

Tyrosines 1015 and 1062 Are in VivoAutophosphorylation Sites in Ret and Ret-Derived Oncoproteins

2000 • 30 citations

Improved Gene Transfer to Neuroblastoma Cells by a Monoclonal Antibody Targeting RET, a Receptor Tyrosine Kinase

2000 • 24 citations

Molecular diagnosis of multiple endocrine neoplasia Type 2

2003 • 15 citations

Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase

2002 • 14 citations

Response: GDNF recruits the signaling crew into lipid rafts

2001 • 1 citations