Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

1998 • 991 citations

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

1997 • 660 citations

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

1998 • 659 citations

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

1997 • 559 citations

Peptide Nucleic Acids (PNA): Synthesis, properties and potential applications

1996 • 468 citations

Antisense Oligonucleotides

1995 • 379 citations

Relative Thermodynamic Stability of DNA, RNA, and DNA:RNA Hybrid Duplexes: Relationship with Base Composition and Structure

1995 • 276 citations

Chemical synthesis of DNA and DNA analogs

1991 • 268 citations

Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides?

1996 • 243 citations

HIV-1 Reverse Transcriptase Can Discriminate between Two Conformationally Locked Carbocyclic AZT Triphosphate Analogues

1998 • 158 citations

Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides

1998 • 136 citations

4'-Substituted nucleosides. 4. Synthesis of some 4'-hydroxymethyl nucleosides

1979 • 124 citations

Tricyclo-DNA: A Phosphodiester-Backbone Based DNA Analog Exhibiting Strong Complementary Base-Pairing Properties

1997 • 92 citations

Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties

1996 • 77 citations

Amide Backbones with Conformationally Restricted Furanose Rings: Highly Improved Affinity of the Modified Oligonucleotides for Their RNA Complements

1996 • 74 citations

A Novel Class of Oligonucleotide Analogues Containing 2‘-O,3‘-C-Linked [3.2.0]Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and Molecular Modeling

1998 • 67 citations

Watson-Crick base-pairing properties of bicyclo-DNA

1996 • 56 citations

Novel linear and branched oligodeoxynucleotide analogues containing 4′-c-(hydroxymethyl)thymidine

1995 • 52 citations

Monte Carlo Results for the Effect of Solvation on the Anomeric Equilibrium for 2-Methoxytetrahydropyran

1994 • 51 citations

The effects of 2′- and 3′-alkyl substituents on oligonucleotide hybridization and stability

1994 • 42 citations

Nucleosides and Nucleotides. 174. Synthesis of Oligodeoxynucleotides Containing 4‘-C-[2-[[N-(2-Aminoethyl)carbamoyl]oxy]ethyl]thymidine and Their Thermal Stability and Nuclease-Resistance Properties¹

1998 • 40 citations

Why Study Nucleotide and Nucleic Acid Structure?

1984 • 38 citations

Ab Initio Models for the Nitroaldol (Henry) Reaction

1997 • 35 citations

Oligodeoxynucleotide probes with multiple labels linked to the 4′-position of thymidine monomers: Excellent duplex stability and detection sensitivity

1994 • 30 citations

Synthesis and Conformation of 9-(3'-C-Methyl-beta-D-xylo-furanosyl)adenine and 3'-C-Methyladenosine, Two Sugar-Methylated Nucleoside Analogues.

1989 • 28 citations

Synthesis of oligodeoxynucleotides containing 4′-C-(Hydroxymethyl)thymidine: Novel promising antisense molecules

1995 • 23 citations

Stereoselective Preparation of 3'-C-Allyluridines and 3'-Spiro-gamma-Lactone Uridine Analogues.

1996 • 19 citations

Incorporation of 3′-C-(Hydroxymethyl)thymidine into novel oligodeoxynucleotide analogues

1995 • 13 citations

Synthesis and Evaluation of Oligodeoxynucleotides Containing 3′-C-Aminomethyl-and 3′-C-Amethylthymidine

1997 • 13 citations

Now we know

1993 • 7 citations

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