Relative Thermodynamic Stability of DNA, RNA, and DNA:RNA Hybrid Duplexes: Relationship with Base Composition and Structure

Predicting DNA duplex stability from the base sequence.

1986 • 1,800 citations

Improved free-energy parameters for predictions of RNA duplex stability.

1986 • 1,472 citations

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

1993 • 734 citations

The Anatomy of A-, B-, and Z-DNA

1982 • 645 citations

Form and Function of Retroviral Proviruses

1982 • 627 citations

Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes

1966 • 535 citations

Base-stacking and base-pairing contributions to helix stability: thermodynamics of double-helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp

1983 • 489 citations

Ordered water structure around a B-DNA dodecamer

1983 • 482 citations

Stability and Properties of Double and Triple Helices: Dramatic Effects of RNA or DNA Backbone Composition

1992 • 461 citations

Therapeutic Applications of Oligonucleotides

1992 • 438 citations

DNA-RNA hybrid duplexes containing oligo(dA:rU) sequences are exceptionally unstable and may facilitate termination of transcription

1980 • 299 citations

Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides.

1992 • 257 citations

Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.

1994 • 250 citations

Structure of a DNA : RNA Hybrid Duplex

1993 • 245 citations

Discontinuous DNA Replication

1980 • 224 citations

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

1992 • 223 citations

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

1993 • 201 citations

Physical and chemical characterization of the ordered complexes formed between polyinosinic acid, polycytidylic acid and their deoxyribo-analogues

1965 • 173 citations

Sequence Specific Thermodynamic and Structural Properties for DNA.cntdot.RNA Duplexes

1994 • 164 citations

RNA bulges and the helical periodicity of double-stranded RNA

1990 • 163 citations

Thermodynamics of (dG-dC)3 double-helix formation in water and deuterium oxide

1981 • 146 citations

Calorimetric and spectroscopic investigation of the helix-to-coil transition of a ribo-oligonucleotide: rA7U7

1975 • 137 citations

The DNA strand in DNA.cntdot.RNA hybrid duplexes is neither B-form nor A-form in solution

1993 • 134 citations

Thermodynamic and structural properties of pentamer DNA.cntdot.DNA, RNA.cntdot.RNA and DNA.cntdot.RNA duplexes of identical sequence

1991 • 111 citations

DNA-RNA hybrid secondary structures

1986 • 105 citations

Dependence of B-A Conformational Change in DNA on Base Composition

1972 • 102 citations

Circular dichroism spectra of poly[d(AC):d(GT)], poly[r(AC):r(GU)], and hybrids poly[d(AC):r(GU)] and poly[r(AC):d(GT)] in the presence of ethanol

1975 • 90 citations

Structure and Dynamics of a DNA.cntdot.RNA Hybrid Duplex with a Chiral Phosphorothioate Moiety: NMR and Molecular Dynamics with Conventional and Time-Averaged Restraints

1995 • 88 citations

Molecular and crystal structure of the polynucleotide complex: Polyinosinic acid plus polydeoxycytidylic acid

1970 • 87 citations

DNA and RNA oligomer thermodynamics: The effect of mismatched bases on double‐helix stability

1981 • 79 citations

CC/GG Contacts Facilitate the B to A Transition of DMA in Solution

1986 • 74 citations

Evidence from CD spectra that d(purine)-r(pyrimidine) and r(purine)-d(pyrimidine) hybrids are in different structural classes

1994 • 69 citations

High-resolution NMR study of a synthetic DNA-RNA hybrid dodecamer containing the consensus Pribnow promoter sequence: d(CGTTATAATGCG).cntdot.r(CGCAUUAUAACG)

1989 • 68 citations

Structural Study of a DNA.cntdot.RNA Hybrid Duplex with a Chiral Phosphorothioate Moiety by NMR: Extraction of Distance and Torsion Angle Constraints and Imino Proton Exchange Rates

1994 • 60 citations

Comparative study of ribonucleotides, deoxyribonucleotides, and hybrid oligonucleotide helixes by nuclear magnetic resonance

1981 • 55 citations

A solution structure for poly(rA).cntdot.poly(dT) with different furanose pucker and backbone geometry in rA and dT strands and intrastrand hydrogen bonding of adenine 8CH

1988 • 51 citations

B→A Transitions within a 5 S Ribosomal RNA Gene Are Highly Sequence-specific

1989 • 50 citations

Phosphorus-31 nuclear magnetic resonance of highly oriented DNA fibers. 2. Molecular motions in hydrated DNA

1985 • 38 citations

Raman spectral studies of nucleic acids. 36. Structure in solution of the RNA.cntdot.DNA hybrid (rA)8.cntdot.(dT)8 determined by NMR and Raman spectroscopy

1990 • 27 citations

Direct evidence for a bimorphic structure of a DNA-RNA hybrid, poly(rA).poly(dT), at high relative humidity.

1984 • 25 citations

RecA protein promotes rapid RNA-DNA hybridization in heterogeneous RNA mixtures

1992 • 23 citations

Regulation of Endothelial Cell Adhesion Molecule Expression with Antisense Oligonucleotides

1994 • 22 citations