The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

1991 • 3,211 citations

The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides

1978 • 2,873 citations

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

1993 • 2,034 citations

Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity

1978 • 1,651 citations

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

1993 • 734 citations

Base-stacking and base-pairing contributions to helix stability: thermodynamics of double-helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp

1983 • 489 citations

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

1993 • 410 citations

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

1993 • 405 citations

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

1997 • 366 citations

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides

1987 • 356 citations

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

1995 • 344 citations

Nucleosides and Nucleotides as Antitumor and Antiviral Agents

1993 • 280 citations

Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides.

1992 • 257 citations

Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides?

1996 • 243 citations

Heats of the helix–coil transitions of the poly A–poly U complexes

1968 • 230 citations

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

1993 • 201 citations

Morpholino and Phosphorothioate Antisense Oligomers Compared in Cell-Free and In-Cell Systems

1997 • 174 citations

Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC

1989 • 163 citations

The contribution of DNA single-stranded order to the thermodynamics of duplex formation.

1991 • 155 citations

Oligonucleotide N3'-->P5' phosphoramidates.

1995 • 147 citations

Thermodynamics of (dG-dC)3 double-helix formation in water and deuterium oxide

1981 • 146 citations

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C- raf kinase supports an antisense mechanism of action in vivo

1996 • 136 citations

2'-O-alkyl oligoribonucleotides as antisense probes.

1990 • 130 citations

2‘-O-Aminopropyl Ribonucleotides: A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides

1996 • 126 citations

Oligonucleotide duplexes containing 2′-amino-2′-deoxycytidines: thermal stability and chemical reactivity

1994 • 125 citations

Carbohydrate Modifications in Antisense Research

1994 • 120 citations

Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents.

1986 • 107 citations

Antisense oligonucleotides made of 2'‐O‐alkylRNA: their properties and applications in RNA biochemistry

1993 • 105 citations

Site and Mechanism of Antisense Inhibition by C-5 Propyne Oligonucleotides

1995 • 95 citations

Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances

1985 • 88 citations

Cancer Therapeutics: Experimental And Clinical Agents

1997 • 84 citations

DNA and RNA oligomer thermodynamics: The effect of mismatched bases on double‐helix stability

1981 • 79 citations

Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties

1996 • 77 citations

Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines

1993 • 70 citations

Oligodeoxynucleotides containing C-7 propyne analogs of 7-deaza-2'- deoxyguanosine and 7-deaza-2'-deoxyadenosine

1996 • 62 citations

Solvent effects on the stability of A7U7p

1985 • 59 citations

Tautomerism of the nucleoside antibiotic formycin, as studied by carbon-13 nuclear magnetic resonance

1973 • 54 citations

Physical properties of oligonucleotides containing phosphoramidate-modified internucleoside linkages

1991 • 52 citations

Biochemical and Physicochemical Properties of Phosphorodithioate DNA

1996 • 50 citations

An oligodeoxyribonucleotide N3'--> P5' phosphoramidate duplex forms an A-type helix in solution

1996 • 46 citations

Evaluation of some properties of a phosphorodithioate oligodeoxyribonucleotide for antisense application

1993 • 46 citations

Synthesis of Novel Nucleic Acid Mimics via the Stereoselective Intermolecular Radical Coupling of 3‘-Iodo Nucleosides and Formaldoximes¹

1996 • 41 citations

Development of Antisense and Antigene Oligonucleotide Analogs

1996 • 36 citations

Oligodeoxynucleoside phosphoramidates (P-NH2): synthesis and thermal stability of duplexes with DNA and RNA targets

1996 • 33 citations

Laser temperature jump study of solvent effects on poly(adenylic acid) stacking

1980 • 33 citations

Investigation of some properties of oligodeoxynucleotides containing 4'- thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity

1996 • 30 citations

Temperature‐jump kinetics of the dC‐G‐T‐G‐A‐A‐T‐T‐C‐G‐C‐G double helix containing a G·T base pair and the dC‐G‐C‐A‐G‐A‐A‐T‐T‐C‐G‐C‐G double helix containing an extra adenine

1983 • 26 citations

Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

1995 • 25 citations

Molecular orbital studies on nucleoside analogs II. Conformation of 6-azapyrimidine nucleosides

1978 • 17 citations

Transport of uridine and 6-azauridine in human lymphoblastoid cells. Specificity for the uncharged 6-azauridine molecule.

1983 • 13 citations

A change of backbone

1991 • 7 citations