Review

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 • 606 citations

Role of Matrix Metalloproteinases in Human Periodontal Diseases

1993 • 605 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Cytokine regulation of metalloproteinase gene expression

1993 • 432 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

jun:Oncogene and Transcription Factor

1990 • 337 citations

SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.

1993 • 274 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

1995 • 232 citations

Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.

1987 • 217 citations

Interleukin 4 inhibition of prostaglandin E2 synthesis blocks interstitial collagenase and 92-kDa type IV collagenase/gelatinase production by human monocytes.

1992 • 204 citations

Metalloproteinases in degenerative aortic disease

1991 • 196 citations

Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines.

1991 • 194 citations

Matrix metalloproteinases. A review.

1990 • 187 citations

A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor

1993 • 171 citations

Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity.

1991 • 168 citations

Substrate specificities and activation mechanisms of matrix metalloproteinases

1991 • 164 citations

The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts

1991 • 160 citations

lnterleukin-1 Stimulates andAll-Trans-Retinoic Acid Inhibits Collagenase Gene Expression through Its 5′ Activator Protein-1-Binding Site

1990 • 154 citations

Induction of macrophage metalloproteinases by extracellular matrix. Evidence for enzyme- and substrate-specific responses involving prostaglandin-dependent mechanisms.

1993 • 128 citations

Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription

1992 • 122 citations

Post‐Transcriptional regulationa of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts

1992 • 121 citations

Positive and negative transcriptional elements of the human type IV collagenase gene.

1990 • 121 citations

Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA.

1988 • 107 citations

Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases.

1992 • 98 citations

In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage.

1991 • 76 citations

Negative regulation of gene expression by TGF‐β

1992 • 71 citations

Regulation of monocyte/macrophage metalloproteinase production by cytokines.

1993 • 55 citations

Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.

1988 • 49 citations

Structure and biological activity of basement membrane proteins

1989 • 43 citations

An altered IGF-I receptor is present in human leukemic cells.

1990 • 43 citations

Collagen and collagenase: pregnancy and parturition.

1991 • 38 citations

Some Molecular Mechanisms of Glucocorticoid Action

1993 • 23 citations

Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin.

1992 • 15 citations

A 41 kDa transferrin related molecule acts as an autocrine growth factor for HL-60 cells

1991 • 8 citations