Antifungal Peptides: Novel Therapeutic Compounds against Emerging Pathogens

Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

1987 • 2,216 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Sequence and specificity of two antibacterial proteins involved in insect immunity

1981 • 1,358 citations

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

1993 • 986 citations

Identification of the bactericidal domain of lactoferrin

1992 • 878 citations

Cell-Free Immunity in Insects

1987 • 742 citations

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

1989 • 695 citations

Interaction of antimicrobial dermaseptin and its fluorescently labeled analogs with phospholipid membranes

1992 • 646 citations

The Significance of Iron in Infection

1981 • 603 citations

Analysis of two novel classes of plant antifungal proteins from radish (Raphanus sativus L.) seeds.

1992 • 573 citations

Primary structures of three human neutrophil defensins.

1985 • 529 citations

Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.

1988 • 509 citations

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

1991 • 505 citations

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

1993 • 497 citations

Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment

1993 • 494 citations

Antifungal agents: chemotherapeutic targets and immunologic strategies

1996 • 491 citations

Potent Antibacterial Peptides Generated by Pepsin Digestion of Bovine Lactoferrin

1991 • 442 citations

Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides

1994 • 439 citations

Structure, function, and membrane integration of defensins

1995 • 423 citations

Sphingolipid Synthesis as a Target for Antifungal Drugs

1997 • 396 citations

Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae

1995 • 384 citations

A New Family of Plant Antifungal Proteins

1991 • 360 citations

ANTIBIOTICS THAT INHIBIT FUNGAL CELL WALL DEVELOPMENT

1994 • 359 citations

A Potent Antimicrobial Protein from Onion Seeds Showing Sequence Homology to Plant Lipid Transfer Proteins

1995 • 351 citations

Polyoxins, antifungal antibiotics. XIII. Structure of polyoxins

1969 • 333 citations

Zeamatin, an antifungal protein from maize with membrane-permeabilizing activity

1990 • 320 citations

Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus.

1993 • 319 citations

Fungal Membrane Responses Induced by Plant Defensins and Thionins

1996 • 311 citations

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.

1996 • 311 citations

Membrane thinning caused by magainin 2

1995 • 308 citations

Isolation, amino acid sequence and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin

1991 • 305 citations

Magainins and the disruption of membrane-linked free-energy transduction.

1989 • 289 citations

The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms.

1994 • 277 citations

Molecular recognition between membrane-spanning polypeptides

1995 • 277 citations

Synthetic magainin analogues with improved antimicrobial activity

1988 • 277 citations

Bacillomycin: An Antibiotic from Bacillus subtilis Active against Pathogenic Fungi

1948 • 267 citations

Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis

1997 • 244 citations

Defensins

1990 • 241 citations

Stoffwechselprodukte von Mikroorganismen 143. Mitteilung. Echinocandin B, ein neuartiges Polypeptid‐Antibioticum aus Aspergillus nidulans var. echinulatus: Isolierung und Bausteine

1974 • 234 citations

Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations.

1988 • 230 citations

Lipopeptide inhibitors of fungal glucan synthase

1997 • 215 citations

Gallinacins: cysteine‐rich antimicrobial peptides of chicken leukocytes

1994 • 214 citations

Solution structure of .gamma.1-H and .gamma.1-P thionins from barley and wheat endosperm determined by proton NMR: a structural motif common to toxic arthropod proteins

1993 • 207 citations

In Vitro Killing of Spores and Hyphae of Aspergillus fumigatus and Rhizopus oryzae by Rabbit Neutrophil Cationic Peptides and Bronchoalveolar Macrophages

1986 • 195 citations

A Novel Family of Small Cysteine-rich Antimicrobial Peptides from Seed of Impatiens balsaminaIs Derived from a Single Precursor Protein

1997 • 190 citations

Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis

1990 • 183 citations

Synthesis and Solution Structure of the Antimicrobial Peptide Protegrin‐1

1996 • 182 citations

Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic.

1993 • 176 citations

Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872)

1997 • 174 citations

Activity of rabbit leukocyte peptides against Candida albicans

1985 • 167 citations

In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds

1997 • 166 citations

Preliminary experimental anticancer activity of cecropins.

1994 • 161 citations

Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.

1990 • 157 citations

The structure of syringomycins A₁, E and G

1989 • 155 citations

Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties.

1991 • 149 citations

Antimicrobial activity of a 13 amino acid tryptophan‐rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides

1996 • 146 citations

The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense Against gram-negative bacteria and lipopolysaccharide

1993 • 143 citations

Intramolecular Disulfide Bonds Enhance the Antimicrobial and Lytic Activities of Protegrins at Physiological Sodium Chloride Concentrations

1996 • 141 citations

Papulacandin B: an Inhibitor of Glucan Synthesis in Yeast Spheroplasts

1979 • 135 citations

Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin

1987 • 132 citations

The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics.

1993 • 130 citations

Studies on aculeacin. I. Isolation and characterization of aculeacin A.

1977 • 126 citations

Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation

1996 • 125 citations

Pseudomycins, a family of novel peptides from Pseudomonas syringae possessing broad-spectrum antifungal activity.

1991 • 123 citations

Pneumocandin L-743,872 enhances the activities of amphotericin B and fluconazole against Cryptococcus neoformans in vitro

1997 • 122 citations

Molecular Basis for Prokaryotic Specificity of Magainin-Induced Lysis

1995 • 120 citations

Echinocandin inhibition of 1,3-β-D-glucan synthase from Candida albicans

1984 • 120 citations

Purification, characterization, and cDNA cloning of an antifungal protein from the hemolymph of Sarcophaga peregrina (flesh fly) larvae

1993 • 117 citations

Structure, synthesis, and activity of Dermaseptin b, a novel vertebrate defensive peptide from frog skin: relationship with adenoregulin

1994 • 115 citations

In vitro and in vivo anti-Candida activity and toxicology of LY121019.

1984 • 112 citations

Fungicidal activity of cecropin A

1997 • 111 citations

A NEW ANTIBIOTIC, LEUCINOSTATIN, DERIVED FROM PENICILLIUM LILACINUM

1973 • 109 citations

Purification and antimicrobial properties of three defensins from rat neutrophils

1989 • 107 citations

Fungicidal action of aureobasidin A, a cyclic depsipeptide antifungal antibiotic, against Saccharomyces cerevisiae

1997 • 106 citations

Comparison of the in vitro activities of the echinocandin LY303366, the pneumocandin MK-0991, and fluconazole against Candida species and Cryptococcus neoformans

1997 • 102 citations

WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties.

1994 • 101 citations

On the mode of action of a new antifungal antibiotic, aculeacin A: Inhibition of cell wall synthesis in Saccharomyces cerevisiae.

1977 • 100 citations

In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinonapeptides produced by Pseudomonas syringae pv. syringae

1996 • 100 citations

In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species

1997 • 99 citations

L-671,329, a new antifungal agent. I. Fermentation and isolation.

1989 • 98 citations

Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity

1985 • 97 citations

Structure of aureobasidin A.

1991 • 95 citations

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

1992 • 94 citations

Polyoxin D inhibits growth of zoopathogenic fungi

1983 • 92 citations

Role of cell-binding in the antibacterial mechanism of lactoferricin B.

1993 • 90 citations

Studies on Polyoxins, Antifungal Antibiotics

1967 • 89 citations

Cyclopeptide alkaloids

1997 • 89 citations

Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity

1988 • 85 citations

The biological significance of lactoferrin.

1983 • 85 citations

Effect of papulacandin B and aculeacin A on β‐(1,3) glucan‐synthase from geotrichum lactis

1981 • 83 citations

Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes

1981 • 83 citations

In vitro susceptibilities of clinical yeast isolates to a new echinocandin derivative, LY303366, and other antifungal agents

1997 • 83 citations

Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins.

1993 • 82 citations

Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis

1995 • 80 citations

Mechanism of Action of Nikkomycin and the Peptide Transport System of Candida albicans

1985 • 78 citations

Studies on peptide antibiotics, leucinostatins. II. The structures of leucinostatins A and B.

1983 • 77 citations

Properties of Voltage-gated Ion Channels Formed by Syringomycin E in Planar Lipid Bilayers

1996 • 77 citations

STUDIES ON THE MODE OF ACTION OF POLYOXINS. VI

1974 • 76 citations

Fungicidal and binding properties of the natural peptides cecropin B and dermaseptin

1998 • 76 citations

Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis

1991 • 75 citations

Purification and cDNA Cloning of an Antifungal Protein from the Hemolymph of Holotrichia diomphalia Larvae.

1995 • 75 citations

Fungicin M4: a narrow spectrum peptide antibiotic from Bacillus licheniformis M‐4

1994 • 74 citations

Antifungal dynamics of LY 303366, an investigational echinocandin B analog, against Candida ssp.

1996 • 74 citations

In vitro activity of a new echinocandin, LY303366, compared with those of amphotericin B and fluconazole against clinical yeast isolates

1997 • 72 citations

Synthesis and Evaluation of LY121019, a Member of a Series of Semisynthetic Analogues of the Antifungal Lipopeptide Echinocandin Ba

1988 • 72 citations

Struktur des cyclopeptid-antibiotikums sl 7810 (= echinocandinb)

1976 • 72 citations

Schizotrin A; a novel antimicrobial cyclic peptide from a cyanobacterium

1994 • 71 citations

cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils

1992 • 70 citations

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)

1992 • 70 citations

Human neutrophil peptide defensins induce single strand DNA breaks in target cells

1991 • 66 citations

Phytotoxins and Plant Pathogenesis

1991 • 64 citations

Mulundocandin, a new lipopeptide antibiotic. I Taxonomy, fermentation, isolation and characterization.

1987 • 62 citations

Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. II. Physico-chemical properties and structure elucidation.

1994 • 60 citations

Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. I. Taxonomy, production, isolation and biological activity.

1994 • 59 citations

Anti‐Candida Activity and Toxicology of LY121019, a Novel Semisynthetic Polypeptide Antifungal Antibiotica

1988 • 59 citations

Determination of the disulfide array of the first inducible antifungal peptide from insects: drosomycin from Drosophila melanogaster

1996 • 57 citations

WF11899A, B and C, novel antifungal lipopeptides. II. Biological properties.

1994 • 57 citations

Bacillomycin F, a new antibiotic of iturin group: isolation and characterization.

1982 • 57 citations

Cyclopeptid‐Antibiotika aus Aspergillus‐Arten. Struktur der Echinocandine C und D

1979 • 57 citations

A NEW ANTIBIOTIC, POLYOXIN A.

1965 • 57 citations

Synthesis of new analogs of echinocandin B by enzymatic deacylation and chemical reacylation of the echinocandin B peptide: Synthesis of the antifungal agent cilofungin (LY121019).

1989 • 56 citations

Surface‐active properties of antifungal lipopeptides produced byBacillus subtilis

1992 • 56 citations

Isolement de l'acide 3-amino 12-methyl tetradecanoique et de l'acide 3-amino 12-methyl tridecanoique a partir de l'iturine, antibiotique de Bacillus subtilis

1973 • 56 citations

Chitin biosynthesis in Candida albicans grown in vitro and in vivo and its inhibition by nikkomycin Z

1992 • 56 citations

Determination of disulphide bridges in PG‐2, an antimicrobial peptide from porcine leukocytes

1995 • 55 citations

Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach

1992 • 55 citations

In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373

1995 • 52 citations

Interaction between Polyoxin and Active Center of Chitin Synthetase

1974 • 52 citations

Section Review: Anti-infectives: Lipopeptide antifungal agents

1994 • 51 citations

Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide D4E1

1998 • 51 citations

Interactions of antibiotics of the iturin group with human erythrocytes

1986 • 50 citations

Inhibition of some mycotoxigenic fungi by iturin A, a peptidolipid produced by Bacillus subtilis

1991 • 50 citations

Action of antifungal peptidolipids from Bacillus subtilis on the cell membrane of Saccharomyces cerevisiae.

1984 • 50 citations

Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis

1995 • 50 citations

Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo

1992 • 49 citations

Studies on aculeacin. II. Isolation and characterization of aculeacins B, C, D, E, F and G.

1977 • 49 citations

Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis

1991 • 48 citations

Effects ofPseudomonas syringaePhytotoxin, Syringomycin, on Plasma Membrane Functions ofRhodotorula pilimanae

1987 • 48 citations

Helioferins; Novel Antifungal Lipopeptides From Mycogone rosea: Screening, Isolation, Structures and Biological Properties.

1995 • 47 citations

In Vitro Effect of Phagocyte Cationic Peptides on Coccidioides immitis

1985 • 47 citations

Deoxymulundocandin-A new echinocandin type antifungal antibiotic.

1992 • 47 citations

Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B.

1983 • 46 citations

Leucinostatin D. A novel peptide antibiotic from Paecilomyces marquandii.

1987 • 44 citations

L-671,329, a new antifungal agent. III. In vitro activity, toxicity and efficacy in comparison to aculeacin.

1989 • 44 citations

Fungicidal properties of defensin NP-1 and activity against Cryptococcus neoformans in vitro

1993 • 43 citations

Leucinostatins H and K, two novel peptide antibiotics with tertiay amine-oxide terminal group from Paecilomyces marquandii Isolation, structure and biological activity.

1987 • 41 citations

Mulundocandin, a new lipopeptide antibiotic. II Structure elucidation.

1987 • 38 citations

Comparative in vitro activity of LY121019 and amphotericin B against clinical isolates ofCandida species

1988 • 38 citations

Structures of aureobasidins B to R.

1991 • 38 citations

New peptide antibiotics, trichopolyns I and II, from Trichoderma polysporum

1981 • 37 citations

¹H‐nmr studies on the structure of a new thionin from barley endosperm

1995 • 37 citations

Isolation and physico-chemical characterization of an antifungal and antibacterial peptide produced by Bacillus licheniformis A12

1993 • 36 citations

Action of iturin A, an antifungal antibiotic from Bacillus subtilis, on the yeast Saccharomyces cerevisiae: Modifications of membrane permeability and lipid composition.

1987 • 35 citations

New antibiotics, trichopolyns A and B: Isolation and biological activity

1978 • 34 citations

Isolation and characterization of a 25 kDa antifungal protein from flax seeds

1992 • 34 citations

In vitro activities of semisynthetic pneumocandin L-733,560 against fluconazole-resistant and -susceptible Candida albicans isolates

1996 • 34 citations

Correlation of cilofungin in vivo efficacy with its activity againstAspergillus fumigatus(1,3)-β-d-glucan synthase

1993 • 33 citations

Mechanism of action of the phytotoxin syringomycin: a resistant mutant of Saccharomyces cerevisiae reveals an involvement of Ca2+ transport

1991 • 31 citations

Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats

1992 • 31 citations

Synergistic activity of rabbit granulocyte peptides against Candida albicans

1986 • 29 citations

Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus.

1997 • 29 citations

Structure of leucinostatin B, an uncoupler on mitochondria.

1983 • 29 citations

Total synthesis of an antifungal cyclic depsipeptide aureobasidin A

1996 • 29 citations

Fungicidal and binding properties of the natural peptides cecropin B and dermaseptin

1998 • 28 citations

Biologically Active Cyclopeptide Alkaloids from Rhamnaceae Plants

1990 • 28 citations

Yeast genes involved in growth inhibition byPseudomonas syringaepv.syringaesyringomycin family lipodepsipeptides

1993 • 26 citations

Mechanism of action of bacterial phytotoxin, syringomycin. Simultaneous measurement of early responses in yeast and maize

1987 • 25 citations

Echinocandin Antifungal Agents

1997 • 24 citations

Fungicidal and binding properties of three plant peptides.

1998 • 23 citations

Sensitivity of Fungi to Nikkomycin Z

1996 • 23 citations

Relative rates of transport of peptidyl drugs by Candida albicans

1985 • 23 citations

Transport and Hydrolysis of Peptides in Saccharomyces cerevisiae

1986 • 23 citations

Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents

1989 • 23 citations

Papulacandin, a new antibiotic, active especially against yeasts

1977 • 21 citations

Adhesion of Candida albicans to epithelial cells effect of polyoxin D

1991 • 21 citations

Efficacy of Syringomycin E in a Murine Model of Vaginal Candidiasis.

1998 • 20 citations

Properties and Structure of a novel peptide antibiotic No. 1907.

1980 • 19 citations

Effects of synthetic form of tracheal antimicrobial peptide on respiratory pathogens

1996 • 18 citations

Constituents of a peptidal antibiotic P168 produced by Paecilomyces lilacinus (Thom) Samson.

1980 • 18 citations

FR900403, A new antifungal antibiotic produced by a Kernia sp.

1990 • 16 citations

Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits

1992 • 14 citations

Syringomycin Effects on Plasma Membrane Ca+2 Transport

1989 • 14 citations

Purification and Properties of a New Chitin-binding Antifungal CB-1 fromBacillus licheniformis

1996 • 13 citations

Structure of a peptidal antibiotic P168 produced by Paecilomyces lilacinus (Thom) Samson.

1980 • 9 citations

Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560

1997 • 7 citations

[Treatment of dermatomycoses with iturin].

1956 • 5 citations

Structure-function relationships of antimicrobial dermaseptins

1995 • 4 citations

News on HIV therapies from the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy

1997 • 2 citations

[Clinical and biological trials on iturine, a new antifungal drug].

1958 • 1 citations