Saporin Conjugates and Pain

Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor

1997 • 622 citations

Receptor Endocytosis and Dendrite Reshaping in Spinal Neurons After Somatosensory Stimulation

1995 • 483 citations

Transmission of Chronic Nociception by Spinal Neurons Expressing the Substance P Receptor

1999 • 446 citations

Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways

2002 • 423 citations

Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain

2002 • 343 citations

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

1995 • 292 citations

The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles

1998 • 287 citations

Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem

2000 • 276 citations

Inhibition of Neuropathic Pain by Selective Ablation of Brainstem Medullary Cells Expressing the μ-Opioid Receptor

2001 • 259 citations

Selective agonists for substance P and neurokinin receptors

1987 • 239 citations

Spinal Neurons that Possess the Substance P Receptor Are Required for the Development of Central Sensitization

2002 • 232 citations

Anatomy of Primary Afferents and Projection Neurones in the Rat Spinal Dorsal Horn with Particular Emphasis on Substance P and the Neurokinin 1 Receptor

2002 • 178 citations

Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings

1996 • 159 citations

IDENTIFICATION OF DERMORPHIN AND HYP6‐DERMORPHIN IN SKIN EXTRACTS OF THE BRAZILIAN FROG PHYLLOMEDUSA RHODEI

1981 • 155 citations

Enhanced Evoked Excitatory Transmitter Release in Experimental Neuropathy Requires Descending Facilitation

2003 • 151 citations

Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing

1999 • 128 citations

Central oxytocin and ANP receptors mediate osmotic inhibition of salt appetite in rats

1995 • 110 citations

Central oxytocin inhibition of salt appetite in rats: evidence for differential sensing of plasma sodium and osmolality.

1993 • 83 citations

Intrathecal substance p–saporin attenuates operant escape from nociceptive thermal stimuli

2003 • 80 citations

Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats

1997 • 61 citations

Activation of Coeruleospinal Noradrenergic Inhibitory Controls during Withdrawal from Morphine in the Rat

1998 • 61 citations

The Role of the Spinal Opioid Receptor Like1 Receptor, the NK-1 Receptor, and Cyclooxygenase-2 in Maintaining Postoperative Pain in the Rat

1999 • 51 citations

Noradrenergic lesioning with an anti-dopamine β-hydroxylase immunotoxin

1994 • 48 citations

Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase‐resistant analog of Substance P

2001 • 47 citations

Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11]substance P-saporin

1999 • 46 citations

Targeted toxins in pain

2003 • 46 citations

125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system

1990 • 38 citations

Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat

2000 • 38 citations

C-type natriuretic peptide mediates the hypothalamic actions of the natriuretic peptides to inhibit luteinizing hormone secretion.

1993 • 38 citations

C-type natriuretic peptide mediates the hypothalamic actions of the natriuretic peptides to inhibit luteinizing hormone secretion

1993 • 25 citations

Ricin‐Cytotoxin Conjugate Administration Reveals a Physiologically Relevant Role for Oxytocin in the Control of Gonadotropin Secretiona

1992 • 22 citations

Anti-dopamine beta-hydroxylase immunotoxin-induced sympathectomy in adult rats.

1995 • 17 citations

Central peptidergic mechanisms controlling reproductive hormone secretion: Novel methodology reveals a role for the natriuretic peptides

1992 • 17 citations

The Role of the Spinal Opioid Receptor Like1 Receptor, the NK-1 Receptor, and Cyclooxygenase-2 in Maintaining Postoperative Pain in the Rat

1999 • 3 citations