The Role of the Spinal Opioid Receptor Like1 Receptor, the NK-1 Receptor, and Cyclooxygenase-2 in Maintaining Postoperative Pain in the Rat

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization

1993 • 1,661 citations

Characterization of a rat model of incisional pain

1996 • 1,046 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

1990 • 312 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

A new selective antagonist of the nociceptin receptor

1998 • 239 citations

n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters.

1984 • 203 citations

Prostanoids synthesized by cyclo‐oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability

1997 • 194 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 160 citations

Lack of Effect of Intrathecally Administered N-methyl-D-aspartate Receptor Antagonists in a Rat Model for Postoperative Pain

1998 • 152 citations

Intrathecal Clonidine as a Sole Analgesic for Pain Relief after Cesarean Section

1992 • 151 citations

Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine

1993 • 147 citations

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo

1996 • 133 citations

Intrathecal non-NMDA excitatory amino acid receptor antagonists inhibit pain behaviors in a rat model of postoperative pain

1998 • 131 citations

Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test

1997 • 130 citations

Nociceptin induced inhibition of K⁺ evoked glutamate release from rat cerebrocortical slices

1996 • 128 citations

Cancer pain relieved by long-term epidural morphine with permanent indwelling systems for self-administration

1981 • 109 citations

Myoclonic Seizure Activity with Chronic High-Dose Spinal Opioid Administration

1990 • 107 citations

EC array sensor concepts and data

1987 • 93 citations

Human brain metabolism of morphine and naloxone

1988 • 93 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 88 citations

Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat

1997 • 81 citations

Two populations of spinothalamic tract neurons with opposite responses to 5-hydroxytryptamine

1979 • 79 citations

Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids

1999 • 77 citations

Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw

1997 • 76 citations

Lamotrigine in Rett Syndrome

1993 • 63 citations

Evidence that [Phe¹ψ(CH₂‐NH)Gly²]nociceptin‐(1‐13)‐NH₂, a peripheral ORL‐1 receptor antagonist, acts as an agonist in the rat spinal cord

1998 • 57 citations

Role of spinal cyclooxygenase (COX)-2 on thermal hyperalgesia evoked by carageenan injection in the rat

1997 • 54 citations

Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methysergide

1980 • 52 citations

Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats

1997 • 50 citations

Effects of Intrathecally Administered Nociceptin, and Opioid Receptor-like1Receptor Agonist, and N-methyl-D-aspartate Receptor Antagonistst on the Thermal Hyperalgesia Induced by Partial Sciatic Nerve Injury in the Rat

1997 • 49 citations

Intraventricular morphine for intractable pain of advanced cancer

1993 • 39 citations

Iatrogenic neurotoxicity in cancer patients

1989 • 27 citations

Investigation of the specificity of FK 888 as a tachykinin NK₁ receptor antagonist

1994 • 24 citations

Differential Effect of Central versus Parenteral Administration of Morphine Sulf ate on Regional Concentrations of Reduced Glutathione in Rat Brain

1997 • 21 citations

Human Brain Sulphotransferase and Glucuronyltransferase

1990 • 20 citations

Neurotransmission and the experience of low back pain; no association between csf monoamine metabolites and pain

1985 • 18 citations

The sensitivity to noxious heat in relation to brain and liver opioid glucuronidation in inbred strains of mice

1989 • 13 citations

Levels of morphine and metabolites in CSF during respiratory depression after intraventricular morphine injection

1991 • 12 citations

Combined liquid-solid chromatography and radioimmunoassay for determination of morphine in human fluids

1984 • 8 citations