G Protein GTPase-Activating Proteins: Regulation of Speed, Amplitude, and Signaling Selectivity

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel

1993 • 600 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

Inhibition of Adenylyl Cyclase by G _iα

1993 • 402 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Different β-subunits determine G-protein interaction with transmembrane receptors

1992 • 390 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

Atrial G protein-activated K+ channel: expression cloning and molecular properties.

1993 • 355 citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

1992 • 340 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

Regulators and Effectors of ras Proteins

1991 • 303 citations

Gz, a guanine nucleotide-binding protein with unique biochemical properties.

1990 • 282 citations

The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go.

1987 • 231 citations

Reconstitution of catecholamine-stimulated guanosine triphosphatase activity

1983 • 213 citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.

1985 • 206 citations

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

1988 • 205 citations

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.

1987 • 190 citations

ras and GAP—Who's controlling whom?

1990 • 185 citations

Differential G protein—mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro

1989 • 180 citations

Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

1989 • 180 citations

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles.

1984 • 158 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates.

1985 • 143 citations

A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes

1993 • 133 citations

The importance of G-protein βλ subunits

1993 • 116 citations

cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.

1991 • 102 citations

Deactivation kinetics of the transduction cascade of vision.

1991 • 101 citations

Inhibition of magnesium uptake by beta-adrenergic agonists and prostaglandin E1 is not mediated by cyclic AMP.

1980 • 94 citations

Retinal rod GTPase turnover rate increases with concentration: A key to the control of visual excitation?

1987 • 93 citations

β-Adrenergic and Somatostatin Receptors Regulate Na-H Exchange Independent of cAMP

1989 • 84 citations

Enhanced GTPase activity of transducin when bound to cGMP phosphodiesterase in bovine retinal rods.

1992 • 79 citations

Characterization of transducin from bovine retinal rod outer segments. Mechanism and effects of cholera toxin-catalyzed ADP-ribosylation.

1984 • 79 citations

GTP hydrolysis by purified .alpha.-subunit of transducin and its complex with the cyclic GMP phosphodiesterase inhibitor

1993 • 78 citations

Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.

1992 • 76 citations

Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins.

1994 • 73 citations

Selectivity of the .beta.-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant .alpha. subunits in reconstituted phospholipid vesicles

1991 • 66 citations

Regulation of G protein function by an effector in GTP-dependent signal transduction. An inhibitory subunit of cGMP phosphodiesterase inhibits GTP hydrolysis by transducin in vertebrate rod photoreceptors.

1993 • 63 citations

G-protein-mediated activation of turkey erythrocyte phospholipase C by β-adrenergic and P2y-purinergic receptors

1992 • 40 citations

Beta-adrenergic receptor-mediated phospholipase C activation independent of cAMP formation in turkey erythrocyte membranes

1991 • 38 citations

Contribution of the guanosinetriphosphatase activity of G-protein to termination of light-activated guanosine cyclic 3',5'-phosphate hydrolysis in retinal rod outer segments

1988 • 31 citations

Rapid binding of guanosine 5'-0-(3-thiotriphosphate) to an apparent complex of .beta.-adrenergic receptor and the GTP-binding regulatory protein Gs

1988 • 31 citations

Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells.

1985 • 24 citations

Mutant constructs of the beta-adrenergic receptor that are uncoupled from adenylyl cyclase retain functional activation of Na-H exchange.

1992 • 20 citations

Interactions of β-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein

1987 • 9 citations