Regulation of G protein function by an effector in GTP-dependent signal transduction. An inhibitory subunit of cGMP phosphodiesterase inhibits GTP hydrolysis by transducin in vertebrate rod photoreceptors.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

Visual excitation and recovery

1991 • 530 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein, Gp

1987 • 356 citations

Molecular biology of the visual pigments

1986 • 335 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

Lipid modification at the N terminus of photoreceptor G-protein α-subunit

1992 • 228 citations

The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated.

1992 • 213 citations

Tubulin binds specifically to the signal-transducing proteins, Gs alpha and Gi alpha 1.

1990 • 204 citations

Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase.

1980 • 141 citations

cGMP is tightly bound to bovine retinal rod phosphodiesterase.

1989 • 138 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein.

1983 • 117 citations

Interactions between the subunits of transducin and cyclic GMP phosphodiesterase in Rana catesbiana rod photoreceptors.

1990 • 110 citations

Reciprocal effects of an inhibitory factor on catalytic activity and noncatalytic cGMP binding sites of rod phosphodiesterase.

1982 • 105 citations

G protein-effector coupling: binding of rod phosphodiesterase inhibitory subunit to transducin

1989 • 104 citations

cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.

1991 • 102 citations

Molecular mechanism of GTP hydrolysis by bovine transducin: pre-steady-state kinetic analyses

1991 • 80 citations

The GTP-binding protein of rod outer segments. I. Role of each subunit in the GTP hydrolytic cycle.

1987 • 58 citations

Interaction of the γ-subunit of retinal rod outer segment phosphodiesterase with transducin

1989 • 50 citations

Photoreceptor GTP binding protein mediates fluoride activation of phosphodiesterase.

1985 • 33 citations

Transducin: A Signaling Switch Regulated by Guanine Nucleotides

1989 • 27 citations

Heterogeneity of the retinal G-protein transducin from frog rod photoreceptors. Biochemical identification and characterization of new subunits.

1992 • 16 citations