Lack of connectivity between the induced and autoimmune repertoires of lpr/lpr mice.

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay

1985 • 1,241 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Properties and Applications of Monoclonal Antibodies Directed against Determinants of the Thy-1 Locus

1979 • 595 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

1984 • 344 citations

A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 • 303 citations

Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies.

1987 • 251 citations

Somatic evolution of variable region structures during an immune response.

1986 • 211 citations

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

1986 • 197 citations

VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes.

1989 • 145 citations

Virus-Induced Autoimmunity

1990 • 144 citations

A 16/6 idiotype—positive anti‐DNA antibody is encoded by a conserved V_H gene with no somatic mutation

1988 • 132 citations

The genetic basis of antibody production: The dominant anti‐arsonate idiotype response of the strain a mouse

1982 • 100 citations

Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype

1977 • 91 citations

V Genes Encoding Autoantibodies: Molecular and Phenotypic Characteristics

1988 • 89 citations

Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.

1987 • 74 citations

Structural Patterns in Anti-DNA Antibodies from MRL/lpr Mice

1989 • 65 citations

Organization of the murine immunoglobulin VH complex in the inbred strains.

1987 • 59 citations

Frequency of occurrence of idiotypes associated with anti-p-azophenylarsonate antibodies arising in mice immunologically suppressed with respect to a cross-reactive idiotype.

1977 • 57 citations

Anti DNA antibody production by lymphoid cells of mice and human systemic lupus erythematosus (SLE)

1973 • 55 citations

Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysates.

1984 • 54 citations

Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype.

1991 • 53 citations

Complexity, polymorphism, and connectivity of mouse V k gene families

1989 • 51 citations

Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.

1991 • 50 citations

Idiotypic analysis of polyclonal and monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.

1985 • 45 citations

Two structurally distinct and independently regulated idiotypic families associated with the A/J response to azophenylarsonate

1981 • 44 citations

Structure, map position, and evolution of two newly diverged mouse Ig VH gene families.

1991 • 39 citations

Germ-line sequence of the DH segment employed in Ars-A antibodies: implications for the generation of junctional diversity.

1986 • 36 citations

The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice.

1987 • 26 citations

Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous.

1984 • 23 citations

Relationship of VH and VL genes encoding three idiotypic families of anti-p-azobenzenearsonate antibodies.

1986 • 22 citations

Ro/SS-A and the pathogenic significance of its antibodies

1989 • 21 citations

Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.

1987 • 19 citations

The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodies.

1989 • 16 citations

The Molecular Origin of Anti-DNA Antibodies

1989 • 14 citations

Defining the structural correlates responsible for loss of arsonate affinity in an IdCR antibody isolated from an autoimmune mouse

1993 • 2 citations