Structure and Function of ras p21: Studies BY Site-Directed Mutagenesis

ras GENES

1987 • 3,818 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

GTP-binding domain: three consensus sequence elements with distinct spacing.

1987 • 602 citations

The role of guanosine 5′-triphosphate in polypeptide chain elongation

1978 • 559 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus

1980 • 356 citations

Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses

1979 • 315 citations

Phosphate‐binding sequences in nucleotide‐binding proteins

1985 • 295 citations

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.

1986 • 285 citations

Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus

1979 • 270 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.

1986 • 203 citations

Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

1985 • 195 citations

Isolation of ras GTP-binding mutants using an in situ colony-binding assay.

1986 • 153 citations

p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation

1979 • 150 citations

The Oncogenic Activation of Human p21 ^ras by a Novel Mechanism

1986 • 130 citations

Regional homology in GTP-binding proto-oncogene products and elongation factors.

1983 • 123 citations

Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.

1984 • 109 citations

Identification of guanine nucleotides bound to ras-encoded proteins in growing yeast cells.

1987 • 98 citations

Induction of Neurite Formation in PC12 Cells by Microinjection of Proto-Oncogenic Ha-ras Protein Preincubated with Guanosine-5′-O-(3-Thiotriphosphate)

1987 • 95 citations

Mutations of the ras gene product p21 that abolish guanine nucleotide binding.

1986 • 91 citations

Biochemical Properties of a Highly Purified v-ras^H p21 Protein Overproduced in Escherichia coli and Inhibition of Its Activities by a Monoclonal Antibody

1985 • 65 citations

Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate).

1987 • 59 citations

Structural significance of the GTP-binding domain of ras p21 studied by site-directed mutagenesis.

1987 • 54 citations

High-Level Expression in Escherichia coli of Enzymatically Active Harvey Murine Sarcoma Virus p21 ^ras Protein

1983 • 50 citations

A structure and some function

1988 • 39 citations

Biochemical properties of a highly purified v-rasH p21 protein overproduced in Escherichia coli and inhibition of its activities by a monoclonal antibody.

1985 • 32 citations

Interaction of ras Oncogene Product p21 with Guanine Nucleotides1

1987 • 32 citations

Structural features of the GDP binding site of elongation factor Tu fromEscherichia colias determined by X-ray diffraction

1981 • 32 citations

Novel phosphorylation of c-ras p21 by protein kinases.

1988 • 25 citations

Reactivity of a sulfhydryl group of the ras oncogene product p21 modulated by GTP binding.

1986 • 24 citations

Mammalian G proteins: models for ras proteins in transmembrane signalling?

1986 • 6 citations