Mutations of the ras gene product p21 that abolish guanine nucleotide binding.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

A novel ras-related gene family

1985 • 487 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Helper-independent transformation by unintegrated Harvey sarcoma virus DNA

1978 • 277 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence.

1985 • 202 citations

Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

1985 • 195 citations

GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence.

1985 • 169 citations

Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein

1985 • 152 citations

Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21

1984 • 144 citations

Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.

1982 • 135 citations

Regional homology in GTP-binding proto-oncogene products and elongation factors.

1983 • 123 citations

Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186

1985 • 120 citations

Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.

1984 • 109 citations

Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.

1984 • 100 citations

Functional organization of the Harvey murine sarcoma virus genome

1980 • 91 citations

Biochemical Properties of a Highly Purified v-ras^H p21 Protein Overproduced in Escherichia coli and Inhibition of Its Activities by a Monoclonal Antibody

1985 • 65 citations

Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding.

1985 • 63 citations

High-Level Expression in Escherichia coli of Enzymatically Active Harvey Murine Sarcoma Virus p21 ^ras Protein

1983 • 50 citations