High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 1,817 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Mutation and Cancer: A Model for Wilms' Tumor of the Kidney<xref ref-type="fn" rid="FN2">2</xref>

1972 • 623 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1- positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization [see comments]

1989 • 422 citations

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

1986 • 371 citations

BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol- resistant epitope

1989 • 315 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Frequent Mutations in the p53 Tumor Suppressor Gene in Human Leukemia T-Cell Lines

1990 • 296 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation

1993 • 275 citations

Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes.

1985 • 267 citations

Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue.

1992 • 257 citations

A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma (‘Ki‐1 lymphoma')

1989 • 253 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

Human p53 gene localized to short arm of chromosome 17

1986 • 222 citations

Morphology in Ki-1 (CD30)-Positive Non Hodgkinʼs Lymphoma Is Correlated with Clinical Features and the Presence of a Unique Chromosomal Abnormality, t(2;5)(p23;q35)

1990 • 203 citations

Mutations of p53 gene and their relation to disease progression in B- cell lymphoma

1992 • 166 citations

Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations

1992 • 132 citations

Epstein-Barr virus DNA and latent gene products in Ki-1 (CD30)-positive anaplastic large cell lymphomas

1991 • 132 citations

The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large-cell lymphoma

1991 • 123 citations

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1983 • 104 citations

Expression of p53 in human leukemia and lymphoma

1986 • 102 citations

Increased expression of p53 protein in human leukemia cells.

1986 • 94 citations

Isolation and mapping of a polymorphic DNA sequence (pYNZ22) on chromosome 17p [D17S30]

1988 • 93 citations

Expression of p53 protein during the cell cycle measured by flow cytometry in human leukemia

1990 • 87 citations

Flow cytometric and immunohistochemical characterization of the gamma/delta T-lymphocyte population in normal human lymphoid tissue and peripheral blood.

1990 • 80 citations

Purification and biochemical characterization of the Epstein-Barr virus-determined nuclear antigen and an associated protein with a 53,000-dalton subunit

1980 • 77 citations

A hypervariable RFLP on chromosome 17pl3 is defined by an arbitrary single copy probe pl44-D6 [HGM9 No. D17S34]

1987 • 58 citations

Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: effects of protein sequence and intracellular environment.

1989 • 52 citations

The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large-cell lymphoma

1991 • 34 citations

Detection of Epstein-Barr virus genome in Ki-1 (CD30)-positive, large-cell anaplastic lymphomas using the polymerase chain reaction.

1992 • 33 citations

DNA ploidy in breast lesions. A comparative study using two commercial image analysis systems and flow cytometry.

1990 • 23 citations

Stabilization of the p53 Transformation-Related Protein in Mouse Fibrosarcoma Cell Lines: Effects of Protein Sequence and Intracellular Environment

1989 • 17 citations

The role of cell cycle activity in the generation of morphologic heterogeneity in non-Hodgkin's lymphoma.

1989 • 10 citations