Modification of Blood Flow

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Characterization of a coronary vasoconstrictor produced by cultured endothelial cells

1985 • 616 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Identification of arginine as a precursor of endothelium-derived relaxing factor.

1988 • 407 citations

Superoxide anion is an endothelium-derived contracting factor

1989 • 398 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

Inhibitory Role of the Endothelium in the Response of Isolated Coronary Arteries to Platelets

1983 • 353 citations

Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.

1982 • 345 citations

Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle

1979 • 301 citations

Tumour microcirculation as a target for hyperthermia

1986 • 294 citations

A New Approach to Cancer Chemotherapy: Selective Enhancement of Tumor Blood Flow With Angiotensin II<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 268 citations

Tumor Blood Flow-Characterization, Modifications, and Role in Hyperthermia

1984 • 226 citations

Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins.

1987 • 190 citations

Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature

1992 • 179 citations

Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture.

1986 • 177 citations

Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells.

1983 • 155 citations

A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments

1991 • 148 citations

Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets

1985 • 143 citations

Comparative pharmacology of EDRF and nitric oxide on vascular strips

1987 • 140 citations

Endothelium-dependent contractions to calcium ionophore A23187, arachidonic acid, and acetylcholine in canine basilar arteries.

1988 • 136 citations

Pentoxifylline: A New Drug for the Treatment of Intermittent Claudication; Mechanism of Action, Pharmacokinetics, Clinical Efficacy and Adverse Effects

1984 • 134 citations

Chemical modification of tumour blood flow

1988 • 132 citations

Activity of flavone acetic acid (NSC-347512) against solid tumors of mice

1986 • 124 citations

Endothelium‐dependent relaxation induced by angiotensin II and histamine in isolated arteries of dog

1984 • 122 citations

Studies on the Exchange of Fluids Between Host and Tumor. II. The Blood Flow of Hepatomas and Other Tumors In Rats and Mice<xref ref-type="fn" rid="FN1">2</xref>

1961 • 121 citations

Tumour Hypoxia: The Picture Has Changed in the 1990s

1994 • 117 citations

Winner of the 1988 Lund Science Award: Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinomain vivo

1989 • 115 citations

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

1982 • 114 citations

Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo

1991 • 112 citations

Acetylcholine-induced contractions in isolated rabbit pulmonary arteries: role of thromboxane A2.

1986 • 111 citations

Blood flow in irradiated mouse sarcoma as determined by the clearance of xenon-133.

1972 • 100 citations

Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma

1989 • 87 citations

Role of endothelium in conversion of angiotensin I to angiotensin II in rabbit aorta.

1984 • 85 citations

Changes of Oxygen Tension in Tumours Induced by Vasoconstrictor and Vasodilator Drugs

1962 • 78 citations

Pathophysiological Mechanisms of Hyperthermia in Cancer Therapy

1990 • 68 citations

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.

1988 • 67 citations

Effect of hyperglycemia on blood flow, pH, and response to hyperthermia (42 degrees) of the Yoshida sarcoma in the rat.

1980 • 65 citations

Vasopressin induces endothelium-dependent relaxations of cerebral and coronary, but not of systemic arteries.

1984 • 65 citations

Modification of human tumor pH by elevation of blood glucose

1987 • 63 citations

Sodium-pump density of cells from dog tracheal mucosa

1985 • 63 citations

Modification of Energy Metabolism and Radiation Response of a Murine Tumor by Changes in Nitric Oxide Availability

1993 • 60 citations

Antitumor effects of recombinant human interleukin 1 alpha in RIF-1 and Panc02 solid tumors.

1988 • 59 citations

Effects of temperature on blood circulation measured with the laser doppler method

1989 • 59 citations

Vascularity and Blood Flow in X-Irradiated Walker Carcinoma 256 of Rats

1972 • 59 citations

The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo

1990 • 58 citations

The Rheological Effects of Cinnarizine and Flunarizine in Normal and Pathologic Conditions

1979 • 58 citations

In vivo targets of recombinant human tumour necrosis factor-α: blood flow, oxygen consumption and growth of isotransplanted rat tumours

1989 • 58 citations

Heterogeneity in tumor microvascular response to radiation

1990 • 57 citations

Increases in tumor response by pentoxifylline alone or in combination with nicotinamide

1992 • 56 citations

Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors.

1990 • 56 citations

Potentiation of RSU-1069 tumour cytotoxicity by 5-hydroxytryptamine (5-HT)

1986 • 54 citations

The effect of pentoxifylline on the flow properties of human blood

1978 • 53 citations

Endothelium-Dependent Vasocontraction in Response to Noradrenaline in the Canine Cerebral Artery

1987 • 50 citations

Potentiation of the tumor cytotoxicity of melphalan by vasodilating drugs

1989 • 48 citations

Increase in Tumor Oxygenation and Radiosensitivity Caused by Pentoxifylline

1992 • 48 citations

Microvasculature of C3H/Bi Mouse Mammary Tumors after X-Irradiation

1975 • 47 citations

Endothelium-dependent contraction induced by nicotine in isolated canine basilar artery -possible involvement of a thromboxane A2 (TXA2) like substance

1988 • 47 citations

Angiogenic attack as a therapeutic strategy for cancer

1991 • 45 citations

Changes in functional vascularity and cell number following x-irradiation of a murine carcinoma

1976 • 45 citations

Interleukin‐1β induces tumor necrosis and early morphologic and metabolic changes in transplantable mouse tumors. Similarities with the anti‐tumor effects of tumor necrosis factor α or β

1989 • 44 citations

Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice

1993 • 43 citations

Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.

1987 • 42 citations

Effects of several vasoactive drugs on the vascular resistance of MT-W9B tumors in W/Fu rats.

1978 • 42 citations

The Current Status of Targeting Tumour Vasculature as a Means of Cancer Therapy: An Overview

1991 • 41 citations

Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent

1987 • 41 citations

Influence of vasoactive drugs and ischaemia on intra-tumour blood flow distribution

1978 • 40 citations

The oxygenation of murine tumor isografts and human tumor xenografts by nicotinamide.

1992 • 38 citations

Effect of Pentoxifylline on the Flow of Polymorphonuclear Leukocytes Through a Model Capillary

1990 • 37 citations

Vascular changes in neuroblastoma of mice following x-irradiation.

1974 • 37 citations

Effect of hydralazine on the blood flow in tumors and normal tissues in rats

1991 • 35 citations

Pharmacoangiography with Angiotensin

1974 • 35 citations

In Vivo ³¹P and ¹H NMR studies of rat brain tumor pH and blood flow during acute hyperglycemia: Differential effects between subcutaneous and intracerebral locations

1989 • 34 citations

Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs

1970 • 32 citations

The Oxygenation of Murine Tumor Isografts and Human Tumor Xenografts by Nicotinamide

1992 • 32 citations

Pentoxifylline--a new drug for the treatment of intermittent claudication.

1989 • 32 citations

Selective drug-induced reduction of blood flow in tumor transplants

1985 • 31 citations

The kinetics of vascular thermotolerance in SCK tumors of A/J mice

1989 • 31 citations

Pathophysiology of Tumors in Hyperthermia

1988 • 30 citations

Diagnostic Improvement with Angiotensin in Renal Angiography

1972 • 27 citations

Response of tumour red blood cell flux to hyperthermia and/or hyperglycaemia

1989 • 26 citations

Radiation-induced Modification of Blood Flow Distribution in a Rat Fibrosarcoma

1991 • 26 citations

The Influence of Vasoactive Agents on the Perfusion of Tumours Growing in Three Sites in the Mouse

1991 • 24 citations

Acute effects of tumor necrosis factor alpha or lymphotoxin on global blood flow, laser Doppler flux, and bioenergetic status of subcutaneous rodent tumors.

1992 • 24 citations

The Effects of Flunarizine, a New Calcium Antagonist, on Human Red Blood Cells in vitro

1980 • 24 citations

THE EFFECTS OF ANGIOTENSIN ON RENAL VASCULARITY IN DOGS

1966 • 21 citations

Studies with a Panel of Tumours Having a Variable Sensitivity to FAA, to Investigate Its Mechanism of Action

1991 • 19 citations

Increase in tumor blood flow by pentoxifylline

1994 • 19 citations

Modification of Tumour Response by Calcium Antagonists in the SCVII/St Tumour Implanted at Two Different Sites

1989 • 19 citations

Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine

1994 • 18 citations

Possible mechanisms involved in tumor radiosensitization following nicotinamide administration

1994 • 18 citations

Effect of Various Calcium Antagonists on Blood Flow and Red Blood Cell Flux in Malignant Tumors

2015 • 18 citations

Antitumor effect of interleukin 1 alpha in combination with hyperthermia.

1993 • 17 citations

Pentoxifylline Increases Rif-1 Tumour pO₂in a Manner Compatible with its Ability to Increase Relative Tumour Perfusion

1995 • 17 citations

Effect of intraperitoneal versus intravenous glucose administration on laser Doppler flow in murine FSaII tumors and normal skin.

1989 • 17 citations

Blood Flow, Vascular Resistance and Oxygen Availability in Malignant Tumours upon Intravenous Flunarizine

1987 • 17 citations

KHT Sarcoma Blood Perfusion Change after Single-dose X-ray Irradiation

1991 • 16 citations

Endothelial-dependent relaxation induced by leukotrienes C4, D4, and E4 in isolated canine arteries.

1988 • 15 citations

Drugs and the delivery of oxygen to tissue

1989 • 15 citations

The effects of oral hydralazine on blood pressure, cardiac output and peripheral resistance with respect to dose, age and acetylator status

1990 • 14 citations

Effects of the radiosensitising agent nicotinamide on relative tissue perfusion and kidney function in C3H mice

1993 • 14 citations

Interleukin-1α-induced Tumour Pathophysiologies Can Be Exploited with Bioreductive Alkylating Agents

1991 • 13 citations

Effects of pharmacological agents on the microcirculation of tumors implanted in the liver.

1977 • 13 citations

Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay

1993 • 12 citations

Effect of Nicotinamide and Pentoxifylline on Normal Tissue and fsa Tumor Oxygenation

1995 • 12 citations

The Relevance of Tumour and Surrounding Normal Tissue Vascular Density in Clinical Hyperthermia of Locally Advanced Breast Carcinoma

1991 • 11 citations

Effect of Vasopressin on Human Renal Circulation Investigated by Angiography and a Dye Dilution Technique

1976 • 9 citations

Systemic Effects of FAA are Enhanced by Implanted Tumours

1991 • 7 citations

Effect of Angiotensin on Normal Renal Circulation Determined by Angiography and a Dye Dilution Technique

1977 • 7 citations

Flavone Acetic Acid: Is Vascular Shutdown the Crucial Mechanism of Action

1991 • 6 citations

RENAL ANGIOGRAPHY UNDER THE INFLUENCE OF VASOPRESSIN AND BRADYKININ

1970 • 5 citations

[Pharmaco-angiography of the kidney].

1973 • 2 citations

Microcirculation of transplanted tumors.

1981 • 2 citations