The oxygenation of murine tumor isografts and human tumor xenografts by nicotinamide.

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

Intermittent blood flow in a murine tumor: radiobiological effects.

1987 • 440 citations

Acute hypoxia in tumors: Implications for modifiers of radiation effects

1986 • 267 citations

Hypoxia in Tumors: A Paradigm for the Approach to Biochemical and Physiologic Heterogeneity

1988 • 246 citations

Evaluation of laser-Doppler flowmetry as a measure of tissue blood flow

1986 • 216 citations

Perfluorochemical Emulsions Can Increase Tumor Radiosensitivity

1984 • 209 citations

The use of fluorescent probes to identify regions of transient perfusion in murine tumors

1989 • 173 citations

Comparative stability of physiological parameters during sustained anesthesia in rats.

1978 • 145 citations

Effect of Nicotinamide on the Microregional Heterogeneity of Oxygen Delivery Within a Murine Tumor

1990 • 144 citations

Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma.

1989 • 126 citations

Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation.

1989 • 124 citations

Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor

1985 • 110 citations

Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells.

1990 • 106 citations

Radiosensitization by Nicotinamide in Vivo: A Greater Enhancement of Tumor Damage Compared to That of Normal Tissues

1987 • 106 citations

On the nature of the radiobiologically hypoxic fraction in tumors

1980 • 75 citations

Blood perfusion measurements in human tumours: Evaluation of laser Doppler methods

1990 • 74 citations

Mechanism of action of the selective tumor radiosensitizer nicotinamide

1988 • 73 citations

Potentiation of chemotherapy by hypoxic cell radiation sensitizers—A review

1982 • 68 citations

Inhibitors of poly(adenosine diphosphoribose) synthetase, examination of metabolic perturbations, and enhancement of radiation response in Chinese hamster cells.

1985 • 65 citations

Effects of temperature on blood circulation measured with the laser doppler method

1989 • 59 citations

The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo

1990 • 58 citations

Sensitizers and protectors in radiotherapy

1985 • 56 citations

A phase I/II study of the use of Fluosol® as an adjuvant to radiation therapy in the treatment of primary high-grade brain tumors

1990 • 55 citations

Clinical trials of hypoxic cell sensitizers

1982 • 55 citations

The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair.

1984 • 50 citations

Preferential tumor radiosensitization by analogs of nicotinamide and benzamide

1986 • 46 citations

Radiosensitization effects of nicotinamide on malignant and normal mouse tissue.

1985 • 46 citations

Radiosensitization by nicotinamide in tumors and normal tissues: The importance of tissue oxygenation status

1989 • 46 citations

Continuous and non-invasive quantification of heat-induced changes in blood flow in the skin and RIF-1 tumour of mice by laser Doppler flowmetry

1987 • 38 citations

Increased radiosensitivity of tumors by perfluorochemicals and carbogen

1985 • 37 citations

Clinical experience with nitroimidazoles as radiosensitizers

1982 • 37 citations

Effects of Fluosol DA 20% and Carbogen on the Radioresponse of SCK Tumors and Skin of A/J Mice

1987 • 35 citations

Cinnarizine and flunarizine as radiation sensitisers in two murine tumours

1988 • 34 citations

Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs

1970 • 32 citations

The response of two human tumor xenografts to fractionated irradiation. the derivation of ratios from growth delay, tumor control, and in vitro cell survival assays

1990 • 28 citations

Nicotinamide as a radiosensitizer of a C3H mouse mammary adenocarcinoma

1984 • 22 citations

Radiosensitizers: A conference preview

1984 • 19 citations

Radiosensitization of Murine Tumors by Fluosol-DA 20%

1990 • 17 citations

Keynote address: Chemical manipulations of tissue oxygenation for therapeutic benefit

1989 • 17 citations

Blood Flow, Vascular Resistance and Oxygen Availability in Malignant Tumours upon Intravenous Flunarizine

1987 • 17 citations