The Role of Subsets of CD4 ⁺ T Cells in Autoimmunity

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Divergent T-cell cytokine patterns in inflammatory arthritis.

1994 • 388 citations

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

1995 • 383 citations

A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus

1994 • 336 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

NK1.1⁺ CD4⁺ CD8‐ thymocytes with specific lymphokine secretion

1993 • 265 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4⁺ T cells

1991 • 218 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

Spontaneous thyroiditis in thymectomized and irradiated Wistar rats.

1973 • 179 citations

Subsets of CD4⁺ T Cells and their Roles in the Induction and Prevention of Autoimmunity

1991 • 174 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

Effect of adjuvant therapy on development of diabetes in mouse and man

1994 • 157 citations

Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis.

1992 • 126 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

1993 • 66 citations

Subsets of Rat CD4+ T Cells Defined by Their Differential Expression of Variants of the CD45 Antigen: Developmental Relationships and In Vitro and In Vivo Functions

1990 • 54 citations

Four CD45/P56^lck‐associated phosphorproteins (pp29‐pp32) undergo alterations in human T cell activation

1992 • 46 citations

Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses

1989 • 44 citations

T helper cell unresponsiveness: Rapid induction in antigen-transgenic and reversion in non-transgenic mice

1994 • 33 citations

Acetylcholine receptor—specific T‐Lymphocyte clones in the normal human immune repertoire: Target epitopes, hla restriction, and membrane phenotypes

1991 • 32 citations

Induction of Diabetes in PVG/c Strain Rats by Manipulation of the Immune System

1990 • 28 citations

Allelic exclusion of α chains in TCRs

1994 • 26 citations

Subsets of CD4+ T cells defined by their expression of different isoforms of the leucocyte-common antigen, CD45

1992 • 19 citations

Edrophonium: An aid in the diagnosis of acute organophosphate poisoning

1986 • 19 citations

Immunoregulation mediated by T-cell clusters.

1994 • 12 citations