Adrenal glucocorticoids as modulators of hippocampal neuron survival, repair and function in the aged rat

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Human Aging: Usual and Successful

1987 • 3,185 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

1991 • 1,690 citations

Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats

1993 • 1,626 citations

Adrenal steroid receptors and actions in the nervous system

1986 • 1,231 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period

1986 • 968 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

The Physiology and Pathology of Exposure to Stress

1951 • 783 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Hippocampal damage associated with prolonged and fatal stress in primates

1989 • 746 citations

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

1984 • 729 citations

Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications

1985 • 677 citations

Glutamine, glutamate and gaba in the central nervous system

1986 • 673 citations

Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation

1992 • 671 citations

Regulation of ACTH Secretion: Variations on a Theme of B

1987 • 668 citations

Infantile Experience and Resistance to Physiological Stress

1957 • 656 citations

Stress Down-Regulates Corticosterone Receptors in a Site-Specific Manner in the Brain*

1984 • 586 citations

Physiological and behavioral effects of infantile stimulation

1967 • 559 citations

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

1989 • 532 citations

Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy

1989 • 520 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

1983 • 515 citations

Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus

1990 • 505 citations

Prolonged Ca ²⁺ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats

1984 • 489 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

On the Role of Brain Mineralocorticoid (Type I) and Glucocorticoid (Type II) Receptors in Neuroendocrine Regulation

1989 • 473 citations

Neonatal Handling Alters Adrenocortical Negative Feedback Sensitivity and Hippocampal Type II Glucocorticoid Receptor Binding in the Rat

1989 • 470 citations

Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids.

1978 • 468 citations

Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis

1989 • 459 citations

Inescapable versus Escapable Shock Modulates Long-Term Potentiation in the Rat Hippocampus

1989 • 458 citations

An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration

1976 • 453 citations

Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions

1972 • 451 citations

Mediation by Corticotropin Releasing Factor (CRF) of Adenohypophysial Hormone Secretion

1986 • 443 citations

Behavioral stress impairs long-term potentiation in rodent hippocampus

1987 • 441 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

Effects of Glucocorticoids and Norepinephrine on the Excitability in the Hippocampus

1989 • 383 citations

Endocrinology and Metabolism.

1988 • 376 citations

Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications

1987 • 375 citations

Glucocorticoids Inhibit Glucose Transport and Glutamate Uptake in Hippocampal Astrocytes: Implications for Glucocorticoid Neurotoxicity

1991 • 357 citations

Glucocorticoids Inhibit Glucose Transport in Cultured Hippocampal Neurons and Glia

1990 • 339 citations

Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus

1990 • 336 citations

Plastic changes in the adrenergic innervation of the rat septal area in response to denervation

1971 • 320 citations

Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis

1986 • 319 citations

The adrenocorticol stress-response in the aged male rat: Impairment of recovery from stress

1983 • 288 citations

Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels

1986 • 288 citations

Depressed Mood and Other Psychiatric Manifestations of Cushingʼs Syndrome: Relationship to Hormone Levels

1981 • 287 citations

Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

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Simple Method of Harvesting Limnoria from Nature

1962 • 280 citations

Neuropsychiatric Manifestations of Patients With Cushing's Syndrome

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Possible Connections between Stress, Diabetes, Obesity, Hypertension and Altered Lipoprotein Metabolism that may Result in Atherosclerosis

1989 • 275 citations

Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging

1989 • 274 citations

Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

1985 • 264 citations

Hemorrhage-Induced Secretion of Corticotropin-Releasing Factor-Like Immunoreactivity into the Rat Hypophysial Portal Circulation and Its Inhibition by Glucocorticoids*

1984 • 260 citations

Spatial learning deficits in old rats: A model for memory decline in the aged

1988 • 255 citations

Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging

1991 • 255 citations

Antidepressants Increase Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Hippocampus in vivo

1992 • 255 citations

Telemetered Recording of Hormone Effects on Hippocampal Neurons

1971 • 254 citations

The process of reinnervation in the dentate gyrus of the adult rat: A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis

1983 • 252 citations

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

1991 • 251 citations

Circadian rhythms of melatonin and cortisol in aging

1989 • 249 citations

Cortisol and Alzheimer's disease, I: Basal studies

1986 • 249 citations

Biochemical effects of corticosteroids on neural tissues

1985 • 248 citations

Steroids and Apparent Cerebral Atrophy on Computed Tomography Scans

1978 • 246 citations

Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats

1984 • 246 citations

Cortisol Hypersecretion and Cognitive Impairment in Depression

1984 • 238 citations

The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters

1985 • 232 citations

Glucocorticoid toxicity in the hippocampus: in vitro demonstration

1988 • 219 citations

Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent

1990 • 207 citations

Growth of a new fiber projection in the brain of adult rats: Re-innervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions

1974 • 206 citations

Basal ACTH, Corticosterone and Corticosterone-Binding Globulin Levels over the Diurnal Cycle, and Age-Related Changes in Hippocampal Type I and Type II Corticosteroid Receptor Binding Capacity in Young and Aged, Handled and Nonhandled Rats

1992 • 200 citations

Participation of the Dorsal Hippocampus in the Glucocorticoid Feedback Effect on Adrenocortical Activity

1980 • 190 citations

Characterization of Rat Brain Aldosterone Receptors Reveals High Affinity for Corticosterone

1983 • 188 citations

Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review

1986 • 188 citations

Reversibility of Cerebral Atrophy in Anorexia Nervosa and Cushingʼs Syndrome

1977 • 187 citations

Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal

1980 • 187 citations

Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence

1993 • 182 citations

Glucocorticoid toxicity in the hippocampus: Temporal aspects of neuronal vulnerability

1985 • 182 citations

Chapter 2 Glucocorticoids, hippocampal damage and the glutamatergic synapse

1990 • 181 citations

Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro.

1990 • 176 citations

Corticosteroid-Binding Globulin in the Rat: Studies on the Sex Difference

1965 • 172 citations

Chronic Dexamethasone Pretreatment Aggravates Ischemic Neuronal Necrosis

1986 • 172 citations

Modification of the corticosterone response curve as a function of handling in infancy

1969 • 163 citations

Corticosterone receptors decline in a site-specific manner in the aged rat brain

1983 • 162 citations

Local Cerebral Glucose Utilization Is Increased in Acutely Adrenalectomized Rats

1988 • 162 citations

Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type

1985 • 161 citations

Lesion-induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and reacquisition of normal synaptic density

1982 • 161 citations

Regulation of Glucocorticoid Receptors in Brain by Corticosterone Treatment of Adrenalectomized Rats

1982 • 159 citations

Enhanced graft survival in the hippocampus following selective denervation

1986 • 158 citations

Elevated Corticosterone Levels

1984 • 154 citations

Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures

1990 • 153 citations

Postnatal development and environmental regulation of hippocampal glucocorticoid and mineralocorticoid receptors

1988 • 150 citations

The adrenocortical axis in the aged rat: Impaired sensitivity to both fast and delayed feedback inhibition

1986 • 149 citations

Thyroid Hormones Influence the Development of Hippocampal Glucocorticoid Receptors in the Rat: A Mechanism for the Effects of Postnatal Handling on the Development of the Adrenocortical Stress Response

1987 • 147 citations

The process of reinnervation in the dentate gyrus of adult rats: time course of increases in mRNA for glial fibrillary acidic protein

1990 • 144 citations

Effects of early experience on adrenocortical reactivity

1969 • 144 citations

Glucocorticoid Feedback Inhibition of Adrenocorticotropic Hormone Secretagogue Release

1990 • 142 citations

The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat

1985 • 142 citations

Adrenocortical Steroids and the Brain

1987 • 141 citations

Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures

1989 • 134 citations

Distribution of glucocorticoid and mineralocorticoid receptor messenger RNA expression in human postmortem hippocampus

1991 • 132 citations

Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat

1977 • 131 citations

Glucocorticoid Endangerment of the Hippocampus: Tissue, Steroid and Receptor Specificity

1990 • 130 citations

Neuropsychological Deficits in Cushing??s Syndrome

1980 • 128 citations

Stress-Induced Secretion of Adrenocorticotropin in Rats Is Inhibited by Administration of Antisera to Ovine Corticotropin-Releasing Factor and Vasopressin*

1985 • 126 citations

Compensatory synapse growth in aged animals after neuronal death

1979 • 126 citations

Chemical adrenalectomy reduces hippocampal damage induced by kainic acid

1988 • 124 citations

Further studies of brain aldosterone binding sites employing new mineralocorticoid and glucocorticoid receptor markers in vitro

1985 • 122 citations

Postnatal handling alters glucocorticoid, but not mineralocorticoid messenger RNA expression in the hippocampus of adult rats

1994 • 120 citations

The effect of aging on stress responsiveness and central corticosteroid receptors in the Brown Norway rat

1992 • 119 citations

Inhibition of Immunoreactive Corticotropin-Releasing Factor Secretion into the Hypophysial-Portal Circulation by Delayed Glucocorticoid Feedback*

1986 • 118 citations

Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection

1990 • 113 citations

The CRH Motoneuron: Differential Peptide Regulation in Neurons with Possible Synaptic, Paracrine, and Endocrine Outputs

1987 • 107 citations

Stress and Glucocorticoids in Aging

1987 • 106 citations

Diminished Diurnal Secretion of Adrenocorticotropin (ACTH), But Not Corticosterone, in Old Male Rats: Possible Relation to Increased Adrenal Sensitivity to ACTHin Vivo*

1987 • 105 citations

Cerebral Atrophy Following ACTH Therapy

1980 • 103 citations

Serum corticosterone level predicts the magnitude of hippocampal primed burst potentiation and depression in urethane-anesthetized rats

1991 • 103 citations

The Pituitary—Adrenal System and the Developing Brain

1970 • 99 citations

Exposure to a novel environment interferes with the induction of hippocampal primed burst potentiation in the behaving rat

1990 • 96 citations

Central 5,7‐Dihydroxytryptamine Lesions Decrease Hippocampal Glucocorticoid and Mineralocorticoid Receptor Messenger Ribonucleic Acid Expression

1990 • 95 citations

Neurotrophic ACTH analogue promotes plasticity of type I corticosteroid receptor in brain of senescent male rats

1988 • 95 citations

Regulation of ischemic hippocampal damage in the gerbil: Adrenalectomy alters the rate of CA1 cell disappearance

1990 • 92 citations

Hydrocortisone administration retards axon sprouting in the rat dentate gyrus

1980 • 90 citations

Effect of Adrenalectomy and Demedullation on the Stress-Induced Impairment of Long-Term Potentiation

1990 • 87 citations

Differential fornix ablations and the circadian rhythmicity of adrenal corticosteroid secretion

1980 • 86 citations

Adrenocortical Responsiveness to Stress and ACTH in Aging Rats

1970 • 86 citations

Regulation of Hypophysiotropic Factors Mediating ACTH Secretiona

1987 • 84 citations

Some age-related changes in pituitary-adrenal function in the male laboratory rat.

1978 • 84 citations

Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors

1988 • 83 citations

Hippocampal inhibition of pituitary-adrenocortical function in female rats

1980 • 81 citations

Mineralcorticoid Receptor in Rat Kidney and Hippocampus: Characterization and Quantitation by Isoelectric Focusing

1983 • 81 citations

Neurobiology of the Hippocampus

1985 • 77 citations

Effect of angiotensin II on ACTH release in vivo: role of corticotropin-releasing factor

1983 • 75 citations

Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: Direct binding studies

1987 • 73 citations

The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats

1983 • 72 citations

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Administration of dexamethasone prior to training blocks ACTH-induced recovery of an extinguished avoidance response.

1985 • 67 citations

Evidence for a role of endogenous corticotropin-releasing factor in cold, ether, immobilization, and traumatic stress.

1985 • 67 citations

Immunohistochemical study of neurons containing corticotropin‐releasing factor in Alzheimer's disease

1987 • 64 citations

Handling in Infancy: Increased Levels of the Hypothalamic Corticotropin Releasing Factor (CRF) Following Exposure to a Novel Situation

1972 • 60 citations

Selective alterations of RNA in rat hippocampus after entorhinal cortex lesioning.

1990 • 56 citations

Steroid suppression of axon sprouting in the hippocampal dentate gyrus of the adult rat: Dose-response relationship

1983 • 53 citations

Age-related changes in glucocorticoid receptor binding and mRNA levels in the rat brain and pituitary

1991 • 52 citations

Temporally graded, age-related impairments in spatial memory in the rat

1989 • 52 citations

Effects of adrenal steroids and their reduced metabolites on hippocampal long-term potentiation

1991 • 48 citations

The development of sex differences in the adrenal morphology and responsiveness in stress of rats from birth to the end of life

1976 • 47 citations

law of deviation of homeostasis and diseases of aging

1981 • 45 citations

Behavioral Models of Aging in Nonhuman Primates

1988 • 45 citations

Glucocorticoid receptors in brain and pituitary of the lactating rat

1989 • 39 citations

Glucocorticoid binding sites in human temporal cortex

1988 • 39 citations

Effects of 5α-dihydrocorticosterone on evoked responses and long-term potentiation

1987 • 38 citations

Protein-Bound Corticosteroid in Human Serum Is Selectively Transported into Rat Brain and Liver in Vivo*

1983 • 37 citations

Feedback Effects of Dexamethasone on Adrenocortical Responses in Rats with Fornix Section

1976 • 37 citations

Chemical differentiation of Type I and Type II receptors for adrenal steroids in brain cytosol

1986 • 34 citations

Psychobiological Aspects of Lactation in Rats

1974 • 30 citations

Medial septal cholinergic lesions increase hippocampal mineralocorticoid and glucocorticoid receptor messenger RNA expression

1992 • 30 citations

Feedback Actions of Adrenal Steroid Hormones

1982 • 22 citations

Réactivité au ‘stress’ et capacité d’adaptation à une situation inhabituelle chez le rat jeune, adulte et âgé

1964 • 22 citations

Electrophysiologic and Clinical Aspects of Glucocorticoids on Certain Neural Systems

1982 • 19 citations

Effects of early experience on the metabolism and production of corticosterone in rats

1976 • 18 citations

Modulation of γ-actin and α1-tubulin expression by corticosterone during neuronal plasticity in the hippocampus

1992 • 16 citations

Kainic Acid‐Induced Decrease in Hippocampal Corticosteroid Receptors

1992 • 11 citations

Regulation of Stress‐induced Secretion of POMC‐derived Peptidesa

1987 • 10 citations

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1964 • 7 citations