Oxidant-induced apoptosis: a consequence of lethal lysosomal leak?

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Functions of Lysosomes

1966 • 2,942 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Apoptosis

1993 • 972 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Lysosomes in Biology and Pathology

1974 • 768 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

DNA precipitation assay: A rapid and simple method for detecting DNA damage in mammalian cells

1988 • 323 citations

A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

1992 • 270 citations

Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis

1994 • 245 citations

Cellular injury induced by oxidative stress is mediated through lysosomal damage

1995 • 240 citations

PHOTOOXIDATIVE DAMAGE TO LYSOSOMES OF CULTURED MACROPHAGES BY ACRIDINE ORANGE

1990 • 173 citations

Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization

1995 • 114 citations

H₂O₂-Mediated Damage to Lysosomal Membranes of J-774 Cells

1993 • 111 citations

Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage

1995 • 83 citations

Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes

1972 • 81 citations

Visualization of iron in cultured macrophages: A cytochemical light and electron microscopic study using autometallography

1993 • 65 citations

Apoptotic Mechanisms in Targeted Neuronal Cell Death by Chromophore-Activated Photolysis

1994 • 58 citations

Beta-radiation from Tracer Doses of³²P Induces Massive Apoptosis in a Burkitt's Lymphoma Cell Line

1992 • 17 citations

Starvation-induced autophagocytosis enhances the susceptibility of insulinoma cells to oxidative stress

1996 • 14 citations