Significance of VLA-4-VCAM-1 interaction and CD44 for transendothelial invasion in a bone marrow metastatic myeloma model.

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

CD44: Structure, Function and Association with the Malignant Process

1997 • 1,004 citations

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

1991 • 675 citations

Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition.

1990 • 639 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

1988 • 508 citations

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

1996 • 421 citations

Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer.

1998 • 327 citations

The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

1999 • 258 citations

CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13.

1997 • 197 citations

Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells.

1999 • 186 citations

CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation.

1997 • 163 citations

Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-kappa B and activating protein-1.

1998 • 144 citations

Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity.

1996 • 144 citations

Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro.

1994 • 128 citations

Site-specific de-N-glycosylation of CD44 can activate hyaluronan binding, and CD44 activation states show distinct threshold densities for hyaluronan binding.

1998 • 109 citations

Interaction of Very Late Antigen-4 with VCAM-1 Supports Transendothelial Chemotaxis of Monocytes by Facilitating Lateral Migration

1998 • 97 citations

Widespread Expression of Chondroitin Sulfate-type Serglycins with CD44 Binding Ability in Hematopoietic Cells

1997 • 79 citations

Expression of antisense CD44 variant 6 inhibits colorectal tumor metastasis and tumor growth in a wound environment.

1998 • 70 citations

Adhesion Molecule Mechanisms Mediating Monocyte Migration Through Synovial Fibroblast and Endothelium Barriers: Role for CD11/CD18, Very Late Antigen-4 (CD49d/CD29), Very Late Antigen-5 (CD49e/CD29), and Vascular Cell Adhesion Molecule-1 (CD106)

1998 • 57 citations

Function and Expression of CD44 during Spreading, Migration, and Invasion of Murine Carcinoma Cells

1998 • 53 citations

Cross-Linking of CD44 on Rheumatoid Synovial Cells Up-Regulates VCAM-1

1999 • 50 citations

Metastasis suppression by the standard CD44 isoform does not require the binding of prostate cancer cells to hyaluronate.

1998 • 48 citations

Functions of domain 1 and 4 of vascular cell adhesion molecule-1 in alpha4 integrin-dependent adhesion under static and flow conditions are differentially regulated.

1996 • 45 citations

Endothelial expression of VCAM-1 in experimental crescentic nephritis and effect of antibodies to very late antigen-4 or VCAM-1 on glomerular injury.

1999 • 45 citations

Adhesion molecules involved in the binding of murine myeloma cells to bone marrow stromal elements

1995 • 42 citations

A novelin vitro assay system for transendothelial tumor cell invasion: significance of E-selectin and α3 integrin in the transendothelial invasion by HT1080 fibrosarcoma cells

1994 • 40 citations

Expression of Retrovirally Transduced IL-1 α in IL-6-Dependent B Cells: A Murine Model of Aggressive Multiple Myeloma

1991 • 24 citations

Overexpressed human CD44s promotes lung colonization during micrometastasis of murine fibrosarcoma cells: Facilitated retention in the lung vasculature

1997 • 22 citations

Association between ICAM-1 expression and metastatic capacity of murine B-cell hybridomas

1993 • 21 citations

Alternatively Spliced CD44 Isoforms Containing Exon v10 Promote Cellular Adhesion through the Recognition of Chondroitin Sulfate-Modified CD44

1999 • 20 citations

Enhancement of type IV collagenases by highly metastatic variants of HT1080 fibrosarcoma cells established by a transendothelial invasion system in vitro.

1998 • 9 citations