Expression of Retrovirally Transduced IL-1 α in IL-6-Dependent B Cells: A Murine Model of Aggressive Multiple Myeloma

Adhesion receptors of the immune system

1990 • 6,585 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5

1982 • 936 citations

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

1984 • 820 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis.

1991 • 628 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

The Leukocyte Integrins

1989 • 542 citations

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

1988 • 508 citations

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

1987 • 417 citations

A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro

1986 • 391 citations

Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.

1990 • 350 citations

A murine model of experimental metastasis to bone and bone marrow.

1988 • 350 citations

Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblasts

1986 • 343 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

Plasma cell myeloma--new biological insights and advances in therapy

1989 • 299 citations

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

1988 • 297 citations

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

1988 • 292 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

1989 • 271 citations

Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells

1988 • 267 citations

Plasma cell myeloma--new biological insights and advances in therapy

1989 • 263 citations

A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure.

1981 • 258 citations

Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.

1988 • 254 citations

Interleukin-1β is a potent inhibitor of bone formation in vitro

1987 • 251 citations

Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

1985 • 232 citations

Antitumor activity of recombinant interleukin 6 in mice.

1990 • 230 citations

Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.

1986 • 207 citations

Molecular basis of homing of intravenously transplanted stem cells to the marrow

1990 • 193 citations

Production of interleukin-1 by bone marrow myeloma cells

1989 • 191 citations

Simple, sensitive and specific bioassay of interleukin-1

1989 • 159 citations

Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

1989 • 141 citations

A Growth-Factor Dependent B-Cell Hybridoma

1986 • 127 citations

Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma

1989 • 126 citations

COOH-Terminal-Modified Interleukin-3 Is Retained Intracellularly and Stimulates Autocrine Growth

1989 • 117 citations

The Immunoglobulin Octanucleotide: Independent Activity and Selective Interaction with Enhancers

1987 • 97 citations

Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.

1988 • 82 citations

Autocrine growth factors and tumourigenic transformation

1990 • 75 citations

Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin‐1β in human osteosarcoma cells: Inhibition of cell proliferation and stimulation of alkaline phosphatase activity

1989 • 74 citations

Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells.

1987 • 73 citations

Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA.

1990 • 71 citations

Homing Receptors and Metastasis

1988 • 71 citations

The murine Il-6 gene maps to the proximal region of chromosome 5.

1989 • 65 citations

Production of interleukin 1 beta, a potent bone resorbing cytokine, by cultured human myeloma cells.

1989 • 61 citations

Role of the macrophage-derived hybridoma growth factor in the in vitro and in vivo proliferation of newly formed B cell hybridomas.

1987 • 52 citations

Suppression of programmed death and G₁ arrest in B‐cell hybridomas by interleukin‐6 is not accompanied by altered expression of immediate early response genes

1990 • 41 citations

Coincidental Acquisition of Growth Autonomy and Metastatic Potential During the Malignant Transformation of Factor-Dependent CCL39 Lung Fibroblasts

1988 • 39 citations

Genetic Tagging of Tumor Cells with Retrovirus Vectors: Clonal Analysis of Tumor Growth and Metastasis In Vivo

1988 • 38 citations

Genetic tagging of tumor cells with retrovirus vectors: clonal analysis of tumor growth and metastasis in vivo.

1988 • 30 citations

Inhibition of differentiation and affinity purification with a monoclonal antibody to a myeloid cell differentiation-inducing protein

1988 • 29 citations

Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells

1989 • 28 citations

Bone Lesions Produced by Transplanted Plasma-Cell Tumors in BALB/c Mice

1962 • 28 citations

An improved retroviral vector for gene transfer into undifferentiated cells

1989 • 23 citations

Leukocytosis in mice following long-term reconstitution with genetically-modified bone marrow cells constitutively expressing interleukin 1α or interleukin 6

1991 • 16 citations

Establishment of a novel factor-dependent myeloid cell line from primary cultures of mouse bone marrow

1991 • 14 citations