Function and Expression of CD44 during Spreading, Migration, and Invasion of Murine Carcinoma Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Proteoglycans: many forms and many functions

1992 • 1,183 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.

1987 • 554 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression.

1993 • 541 citations

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.

1993 • 352 citations

CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.

1991 • 347 citations

CD44H regulates tumor cell migration on hyaluronate-coated substrate.

1992 • 334 citations

Distinct effects of two CD44 isoforms on tumor growth in vivo.

1991 • 315 citations

Splicing choice from ten variant exons establishes CD44 variability

1993 • 291 citations

A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.

1992 • 287 citations

Expression of CD44R1 adhesion molecule in colon carcinomas and metastases

1993 • 284 citations

Regulation of protein kinase C and role in cancer biology

1994 • 258 citations

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.

1994 • 249 citations

Migration of highly aggressive MV3 melanoma cells in 3-dimensional collagen lattices results in local matrix reorganization and shedding of alpha2 and beta1 integrins and CD44.

1997 • 236 citations

Monoclonal antibodies to CD44 and their influence on hyaluronan recognition.

1995 • 129 citations

Surface protein expression and messenger RNA-splicing analysis of CD44 in uterine cervical cancer and normal cervical epithelium.

1994 • 126 citations

Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding

1989 • 120 citations

Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors

1996 • 119 citations

Redistribution of a major cell surface glycoprotein during cell movement.

1984 • 115 citations

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor.

1993 • 108 citations

β2-Chimaerin Is a High Affinity Receptor for the Phorbol Ester Tumor Promoters

1997 • 95 citations

Focal adhesion as a signal transduction organelle

1994 • 93 citations

Mechanisms of metastasis

1992 • 90 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

Suppression of CD44 expression decreases migration and invasion of human glioma cells

1996 • 85 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 84 citations

UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily

1995 • 78 citations

Integrin α3β1 can promote adhesion and spreading of metastatic breast carcinoma cells on the lymph node stroma

1996 • 68 citations

Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism

1994 • 61 citations

Characterization of F3II, a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of a mouse adenocarcinoma

1996 • 53 citations

Activated ras and src induce CD44 overexpression in rat intestinal epithelial cells.

1994 • 51 citations

Intracellular signalling mediated by protein-tyrosine kinases: Networking through phospholipid metabolism

1993 • 49 citations

Epidermal growth factor modulates cell attachment to hyaluronic acid by the cell surface glycoprotein CD44

1996 • 30 citations

Phosphatidylcholine-Specific Phospholipase D Activity Is Elevated in v-Fps-Transformed Cells

1994 • 30 citations

Regulation of Phosphatidic Acid Phosphohydrolase by Epidermal Growth Factor

1996 • 29 citations

Glycoproteins of coated pits, cell junctions, and the entire cell surface revealed by monoclonal antibodies and immunoelectron microscopy.

1983 • 25 citations

A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and β1-integrin point contact distribution

1997 • 23 citations

Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D- and protein kinase C-dependent pathways in murine mammary adenocarcinoma cells

1997 • 18 citations