Correlating Pharmacokinetics and Pharmacodynamics of Benzodiazepines: Problems and Assumptions

Current Status of Benzodiazepines

1983 • 453 citations

Serum Drug Concentrations as Therapeutic Guides

1972 • 265 citations

Dependence, Tolerance, and Addiction to Benzodiazepines: Clinical and Pharmacokinetic Considerations

1978 • 226 citations

Tolerance to the behavioral actions of benzodiazepines

1985 • 200 citations

Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs

1981 • 153 citations

Relative amnesic actions of diazepam, flunitrazepam and lorazepam in man.

1977 • 152 citations

Benzodiazepine Receptors in the Central Nervous System

1982 • 151 citations

In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution.

1983 • 147 citations

Importance of Protein Binding for the Interpretation of Serum or Plasma Drug Concentrations

1982 • 133 citations

Correlation between benzodiazepine receptor occupation and anticonvulsant effects of diazepam

1979 • 127 citations

Brain Uptake of Phenytoin, Phenobarbital, and Diazepam

1979 • 119 citations

Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration

1984 • 113 citations

Benzodiazepine Kinetics: Implications for Therapeutics and Pharmacogeriatrics

1983 • 106 citations

The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.

1981 • 105 citations

The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma

1986 • 103 citations

Elimination Half-Life of Drugs: Value and Limitations

1985 • 101 citations

Entry of diazepam and its major metabolite into cerebrospinal fluid

1980 • 94 citations

IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTION

1983 • 88 citations

Comparative pharmacokinetics and pharmacodynamics of lorazepam, alprazolam and diazepam

1985 • 85 citations

Repeated diazepam dosing in cirrhotic patients: Cumulation and sedation

1983 • 49 citations

The Benzodiazepine Receptor

1981 • 49 citations

Clinical Pharmacokinetics of the Benzodiazepines

1985 • 48 citations

Pharmacokinetics in clinical practice

1985 • 45 citations

Rate of entrance of benzodiazepines into the brain determined by eye movement recording.

1983 • 44 citations

Rational Therapeutic Drug Monitoring

1986 • 41 citations

Tissue distribution of 14C-diazepam and its metabolites in rats.

1982 • 39 citations

Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats.

1987 • 32 citations

Absorption of diazepam and its transfer through the blood-brain barrier after intraperitoneal administration in the rat.

1984 • 24 citations

Diazepam and Lorazepam for Intravenous Surgical Premedication

1978 • 22 citations

Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate

1979 • 21 citations

Tissue Distribution of Diazepam and Its Metabolite Desmethyldiazepam: A Human Autopsy Study

1985 • 20 citations

Benzodiazepine hypnotics: Time course and potency of benzodiazepine receptor occupation after oral application

1983 • 17 citations

Duration of benzodiazepine clinical activity: Lack of direct relationship with plasma half-life

1984 • 11 citations

Deleted Work

1955 • 0 citations