Importance of Protein Binding for the Interpretation of Serum or Plasma Drug Concentrations

Clinical Pharmacokinetics

1975 • 427 citations

Binding of Drugs to Serum Albumin

1976 • 410 citations

Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics

1976 • 375 citations

Disease-induced Changes in the Plasma Binding of Basic Drugs

1980 • 354 citations

Diazepam disposition determinants

1980 • 348 citations

Serum Drug Concentrations as Therapeutic Guides

1972 • 265 citations

The effect of albumin conformation on the binding of warfarin to human serum albumin. The dependence of the binding of warfarin to human serum albumin on the hydrogen, calcium, and chloride ion concentrations as studied by circular dichroism, fluorescence, and equilibrium dialysis.

1980 • 222 citations

Reduced Serum Albumin Concentration in the Elderly: A Report from the Boston Collaborative Drug Surveillance Program

1979 • 203 citations

Oxazepam kinetics: effects of age and sex.

1980 • 203 citations

Serum Concentrations of Free Diphenylhydantoin and their Relationship To Clinical Intoxication

1973 • 142 citations

Pharmacokinetics of drugs in patients with the nephrotic syndrome.

1975 • 137 citations

Diseases and Drug Protein Binding

1978 • 132 citations

Potentiation of Warfarin-Induced Hypoprothrombinemia by Chloral Hydrate

1970 • 99 citations

Entry of diazepam and its major metabolite into cerebrospinal fluid

1980 • 94 citations

The Binding of Drugs to Plasma Proteins from Patients with Poor Renal Function

1976 • 75 citations

Inter‐ and intrasubject variation in diazepam free fraction

1979 • 69 citations

Pharmacokinetic and Clinical Implications of Quinidine Protein Binding

1979 • 61 citations

Voluntary Mental Hospitalization

1972 • 21 citations