Stimulation of a low Km phosphodiesterase from liver by insulin and glucagon.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate

1970 • 3,269 citations

Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells

1971 • 838 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

Purification and Properties of Rabbit Skeletal Muscle Phosphorylase b Kinase^*

1964 • 545 citations

Cyclic 3',5'-Nucleotide Phosphodiesterase

1971 • 531 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 519 citations

Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain

1970 • 491 citations

NEGATIVE COOPERATIVITY IN REGULATORY ENZYMES

1969 • 382 citations

Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.

1976 • 350 citations

An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1970 • 346 citations

Characterization of Cyclic Nucleotide Phosphodiesterases of Rat Tissues

1971 • 297 citations

An Effect of Insulin on Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase Activity in Fat Cells

1973 • 245 citations

Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by Insulin

1972 • 243 citations

Separate Phosphodiesterases for the Hydrolysis of Cyclic Adenosine 3′,5′-Monophosphate and Cyclic Guanosine 3′,5′-Monophosphate in Rat Liver

1973 • 230 citations

Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes.

1976 • 206 citations

Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.

1975 • 203 citations

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1975 • 202 citations

Cyclic 3′,5′-nucleotide phosphodiesterase. Distribution and developmental changes of the enzyme and its protein activator in mammalian tissues and cells

1974 • 198 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat tissues and occurrence of a calcium-plus-magnesium-ion-dependent phosphodiesterase and its protein activator

1975 • 170 citations

Prostaglandin E ₁ Effects on Adenosine 3′:5′-Cyclic Monophosphate Concentration and Phosphodiesterase Activity in Fibroblasts

1972 • 167 citations

A method for deriving kinetic constants for two enzymes acting on the same substrate

1971 • 165 citations

Effect of Insulin and Lipolytic Agents on Rat Adipocyte Low K Cyclic Adenosine 3′ : 5′-Monophosphate Phosphodiesterase

1974 • 165 citations

Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats☆

1974 • 163 citations

Detergent-dispersed Adenylate Cyclase from Rat Brain

1973 • 155 citations

Regulation of Adenosine 3′:5′-Cyclic Monophosphate Phosphodiesterase Activity in Fibroblasts by Intracellular Concentrations of Cyclic Adenosine Monophosphate

1972 • 141 citations

Cyclic nucleotide phosphodiesterase activities of pig coronary arteries

1975 • 137 citations

Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.

1976 • 133 citations

Isolation of a Plasma‐Membrane Subfraction from Rat Liver Containing an Insulin‐Sensitive Cyclic‐AMP Phosphodiesterase

1972 • 113 citations

Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormones

1972 • 109 citations

Actions of insulin, epinephrine, and dibutyryl adenosine cyclic 5'-monophosphate on fat cell protein phosphorylations. Adenosine cyclic 5'-monophosphate dependent and independent mechanisms

1975 • 105 citations

Influence of insulin on cyclic 3?,5?-AMP phosphodiesterase activity in liver, skeletal muscle, adipose tissue, and kidney

1968 • 104 citations

Effect of insulin and growth hormone on rat liver cyclic nucleotide phosphodiesterase

1973 • 76 citations

Basal and hormone-stimulated adenylate cyclase in liver plasma membranes: Measurement by radioimmunoassay of cyclic AMP

1973 • 75 citations

Activation of guanyl cyclase and adenyl cyclase by secretin

1973 • 73 citations

Liver 3': 5'-Nucleotide Phosphodiesterase and its Activity in Rat Livers Perfused with Insulin

1969 • 72 citations

Effects of Epinephrine, Adrenocorticotrophic Hormone, and Theophylline on Adenosine 3′,5′-Monophosphate Phosphodiesterase Activity in Fat Cells

1974 • 68 citations

Cyclic nucleotide phosphodiesterase activities from isolated fat cells: Correlation of subcellular distribution with effects of nucleotides and insulin

1974 • 62 citations

Reduced sensitivity of the hepatic adenylate cyclase-cyclic AMP system to glucagon during sustained hormonal stimulation.

1976 • 59 citations

Activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3′:5′-cyclic monophosphate

1976 • 48 citations

Der Einflu� von Hydrochlorothiazid und anderen sulfonamidierten Diuretica auf die 3?,5?-AMP-Phosphodiesterase-Aktivit�t in der Rattenniere

1968 • 44 citations

An effect of glucagon on 3′,5′-cyclic AMP phosphodiesterase activity in isolated rat hepatocytes

1975 • 35 citations

Activity of 3′, 5′-AMP phosphodiesterase in liver and adipose tissue of normal and diabetic rats

1968 • 27 citations

Heat treatment of rat liver adenosine 3′:5′-monophosphate phosphodiesterase

1974 • 19 citations

Evidence for Separate Sites of Action for the Antilipolytic Effects of Insulin and Prostaglandin E₁

1973 • 14 citations

An important role for glucagon in the regulation of glucose production in vivo

1976 • 11 citations