The diagnostic validity of anxiety disorders and their relationship to depressive illness

Diagnostic Criteria for Use in Psychiatric Research

1972 • 5,688 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

Delineation of two drug-responsive anxiety syndromes

1964 • 903 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

Treatment of Endogenous Anxiety With Phobic, Hysterical, and Hypochondriacal Symptoms

1980 • 733 citations

Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization

1977 • 712 citations

II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

1979 • 666 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

Noradrenergic Function in Panic Anxiety

1984 • 602 citations

A Family Study of Panic Disorder

1983 • 490 citations

Increased Anxiogenic Effects of Caffeine in Panic Disorders

1985 • 427 citations

Lactate Provocation of Panic Attacks

1984 • 392 citations

Reliability of DSM-III Anxiety Disorder Categories Using a New Structured Interview

1983 • 386 citations

Panic Disorder and Major Depression

1983 • 367 citations

Studies in the Classification of Affective Disorders

1972 • 352 citations

Treatment of Phobias

1983 • 341 citations

Treatment of Agoraphobia With Group Exposure In Vivo and Imipramine

1980 • 335 citations

Major Depression in Patients With Agoraphobia and Panic Disorder

1984 • 317 citations

Autonomic and psychic effects of yohimbine hydrochloride

1961 • 302 citations

Monoamine Oxidase Inhibitors

1979 • 298 citations

Importance of Psychiatric Diagnosis in Prediction of Clinical Drug Effects

1967 • 273 citations

CLINICAL OBSERVATIONS IN MANIC-DEPRESSIVE DISEASE

1957 • 268 citations

Adrenergic Function in Patients With Panic Anxiety

1984 • 260 citations

Alprazolam in the treatment of generalized anxiety and panic disorders: A double-blind placebo-controlled study

1982 • 254 citations

Resting Plasma Catecholamine Concentrations in Patients With Depression and Anxiety

1971 • 249 citations

High plasma norepinephrine levels in patients with major affective disorder

1982 • 246 citations

Effects of Clonidine on Anxiety Disorders

1981 • 223 citations

Neurotic illness and its response to anxiolytic and antidepressant treatment

1980 • 216 citations

Panic and Generalized Anxiety Disorders

1982 • 210 citations

Imipramine and Brief Therapist-Aided Exposure in Agoraphobics Having Self-exposure Homework

1983 • 206 citations

Comparison of Alprazolam, Imipramine, and Placebo in the Treatment of Depression

1983 • 197 citations

NEUROCIRCULATORY ASTHENIA (ANXIETY NEUROSIS, EFFORT SYNDROME, NEURASTHENIA)

1950 • 196 citations

The Peripheral Kinetics of Norepinephrine in Depressive Illness

1982 • 193 citations

Family Study of Agoraphobia

1983 • 184 citations

A Benzodiazepine Receptor—Mediated Model of Anxiety

1984 • 184 citations

Diazepam and Propranolol in Panic Disorder and Agoraphobia

1984 • 184 citations

ANXIETY STATES (ANXIETY NEUROSIS)

1973 • 179 citations

Anxiety syndromes and their relationship to depressive illness.

1983 • 173 citations

The psychophysiology of mental illness

1975 • 171 citations

The benzodiazepine--GABA--chloride ionophore receptor complex: common site of minor tranquilizer action.

1981 • 170 citations

Some Biochemical Correlates of Panic Attacks with Agoraphobia and Their Response to a New Treatment

1984 • 161 citations

Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients

1983 • 147 citations

Differentiating Depressed From Anxious Neurotic Outpatients

1974 • 146 citations

The Prognosis of Affective Disorders: the Differentiation of Anxiety States from Depressive Illnesses

1972 • 144 citations

Anxiety disorders and depression: contradictions between family study data and DSM-III conventions

1983 • 141 citations

Benzodiazepines in Depressive Disorders

1978 • 137 citations

A study of the clinical effects of phenelzine and placebo in the treatment of phobic anxiety

1973 • 134 citations

Affective Disorder and Alcoholism in Families of Agoraphobics

1981 • 134 citations

A Family Study of Anxiety Neurosis

1980 • 127 citations

Psychiatric progress

1984 • 125 citations

Differentiating anxiety and depression in anxiety disorders: use of rating scales.

1982 • 123 citations

Assessment of α2 adrenergic autoreceptor function in humans: Effects of oral yohimbine

1982 • 123 citations

Abrupt Discontinuation of Tricyclic Antidepressant Drugs: Evidence for Noradrenergic Hyperactivity

1982 • 121 citations

Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates

1982 • 121 citations

Propranolol in Chronic Anxiety Disorders

1980 • 116 citations

Treatment of spontaneous panic attacks with chlomipramine

1981 • 115 citations

Secondary depression in anxiety disorders

1981 • 107 citations

Panic anxiety: a new biological model.

1984 • 106 citations

The Relationship between Agoraphobia and Primary Affective Disorders

1979 • 102 citations

A Clinical Trial of Phenelzine in Anxiety Depressive and Phobic Neuroses

1977 • 100 citations

Factorial Invariance of Symptom Dimensions in Anxious and Depressive Neuroses

1972 • 96 citations

Studies in the relationship between depressive disorders and anxiety states

1982 • 90 citations

Lack of efficacy of a new antidepressant (bupropion) in the treatment of panic disorder with phobias.

1983 • 83 citations

The Classification of Anxiety and Hysterical States. Part I. Historical Review and Empirical Delineation

1982 • 70 citations

Comparison of generalized anxiety disorder with panic disorder patients.

1982 • 70 citations

Somatic Anxiety Attacks and Propranolol

1976 • 70 citations

Panic disorder and primary unipolar depression

1983 • 67 citations

Psychiatrists' versus Patients' Concepts of Unpleasant Emotions

1978 • 62 citations

Naltrexone precipitated opiate withdrawal in methadone addicted human subjects: Evidence for noradrenergic hyperactivity

1984 • 60 citations

A controlled clinical trial of alprazolam for the treatment of anxiety

1983 • 56 citations

A comparison of alprazolam and imipramine in the treatment of agoraphobia and panic disorder.

1986 • 48 citations

A large open multicentre trial of clomipramine (Anafranil) in the management of phobic disorders.

1977 • 30 citations

Interaction between noradrenergic and serotonergic brain systems as evidenced by behavioral and biochemical effects of microinjections of adrenergic agonists and antagonists into the median raphe nucleus

1983 • 25 citations

Major depression and panic disorder: diagnostic and neurobiological relationships.

1986 • 20 citations

Comparative efficacy and safety of bupropion and placebo in the treatment of depression

1983 • 20 citations

Effects of psychotropic agents on primary depression

1981 • 17 citations

Panic disorder in genotypic HLA identical sibling pairs

1983 • 16 citations